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Patients with congenital hypothyroidism treated with Levothyroxine report neuropsychological sequelae throughout life. Neuropsychological sequelae in patients with CH treatment include several factors: extrinsic, relating to L-T4 therapy and social causes, and intrinsic, such as the severity and etiology of CH, as well as structural and physiological changes in the brain, influence neuropsychological changes. We hypothesized that thyroid hormone hyposensitivity in this review may also contribute to neuropsychological changes by lowering the effectiveness of L-T4 therapy in the brain.
Source link: https://doi.org/10.3390/jcm11123427
Hypothyroidism in patients with solid non-thyroid cancer is a tantalizing disease, integrating an intriguing thyroid hormone-cancer connection with hypothyroidism's complexity. Hypothyroidism in patients with solid non-thyroid disease is reminiscent of hypothyroidism in the general population, but it comes with particular difficulties in cancer due to the dual role of THs in cancer: promotion versus inhibitory. Hypothyroidism is a predictor of a reduced or elevated risk of solid non-thyroid cancer in solid non-thyroid cancer, according to clinical studies, and is a prognostic predictor of stable or unfavorable prognosis in solid non-thyroid cancer. Four prerequisites must be fulfilled in order to harness hypothyroidism, or THs replacement, as a personalized anticancer therapy for solid non-thyroid cancer, including deciphering the dual THs' activities and creating agents that prevent tumor-promoting THs actions; and counteracting current methodological limitations; and deciphering current methodological limitations.
Source link: https://doi.org/10.3390/jcm11123417
Thyroid hormones have a major effect on cell oxidative metabolism. Besides, they maintain vascular homeostasis by positive effects on endothelial and vascular smooth muscle cells. Dyslipidemia, diastolic hypertension, elevated arterial stiffness, endothelial dysfunction, and altered blood coagulation may have all contributed to the rise in the risk of progression and extension of atherosclerosis in patients with SCH and CH. Excessive LT4 substitution may lead to atrial rhythm disorders and osteoporosis in postmenopausal women and elderly patients with hypothyroidism and related vascular comorbidity. This review summarizes the latest scientific evidence on subthyroidism and atherosclerotic cardiovascular disease, as well as the effects of LT4 replacement therapy on restoring biochemical euthyroidism and atherosclerosis pathways.
Source link: https://doi.org/10.2174/1381612828666220620160516
Introduction Adverse pregnancy outcomes in women with subclinical hypothyroidism are well documented, but studies concerning levothyroxine therapy in such cases are ineffective and inconsistent. Our research sought to investigate the effect of levothyroxine treatment on pregnancy outcomes in these women. Using 2017 American Thyroid Association guidelines, pregnant women with singleton pregnancy were tested before 12 weeks of gestation for subthyroidism. The levothyroxine therapy average age at the start of levothyroxine therapy was nine weeks. In women with subthyroidism, gestational hypertension, intra-uterine growth restriction, low birth weight, and preterm birth were not significantly higher than those in euthyroid women, but not so much in women with subthyroidism. However, the risk of gestational diabetes mellitus in women with SCH was significantly higher in women with SCH.
Source link: https://doi.org/10.7759/cureus.24984
Hypothyroidism is often related to pericardial effusion, but it can be less complicated by cardiac tamponade. We chronicle two patients who suffered from shortness of breath and distension of the abdomen, progressing to generalized edema. The occurrence of cardiac tamponade with bradycardia may suggest a hypothyroid etiology.
Source link: https://doi.org/10.5005/jp-journals-10071-24210
Thyroid hormone hormones play a vital role in controlling human metabolism. Hypothyroidism can cause dilated cardiomyopathy and reduced heart function. Myocytes in Cardiac are more sensitive to liothyronine than to levothyroxine. In addition, heart disease, liothyronine and levothyroxine combination therapy may be more effective than levothyroxine monotherapy for hypothyroidism and heart disease.
Source link: https://doi.org/10.6065/apem.2142218.109
This Korean population-based survey sought to explore hypothyroidism after adjuvant radiation therapy in patients with breast cancer. Patients with invasive breast carcinomas were scanned for patients with invasive breast carcinomas using the Korean Health Insurance Review and Assessment Service website. In patients treated with radiation therapy, the odds of hypothyroidism in patients treated with radiation were 9. 3% and 8. 6% in those treated without radiation. Hypothyroidism in Korean patients with breast cancer is one of the most comprehensive population-based research into the risk of hypothyroidism among Korean patients with breast cancer. Patients with breast cancer treated without RT exceeded those for patients with RT-treated breast cancer patients with RT.
Source link: https://doi.org/10.1371/journal.pone.0269893
Graves' ophthalmopathy is often attributed to hyperthyroidism secondary to Graves' disease. Below, we discuss a case of GO developing in a patient who has hypothyroidism secondary to HT and is safely treated with high-dose steroids. We'll explore the case of a 53-year-old female diagnosed with primary hypothyroidism diagnosed at the age of 39 years and has been on levothyroxine since diagnosis. In the euthyroid range, a laboratory experiment revealed a positive thyroid-stimulating immunoglobulin with thyroid-stimulating hormone and free thyroxine. The patient was diagnosed with an active moderate-severe isomorbide isolated GO with a history of HT, medically and biochemically euthyroid on levothyroxine. Graves' ophthalmopathy is unusual occurrence in hypothyroid and euthyroid patients, but it should be factored in the differential diagnosis. Patients with high-dose steroids and transitioned from treating GO secondary to GD showed significant improvement in their symptoms.
Source link: https://doi.org/10.7759/cureus.24954
Thyroid stimulating hormone is typically thought of as a standard measure of thyroid function assessment. The free-triiodothyronine/free-thyroxine ratio of 25 children with congenital hypothyroidism was found in this study, compared to 470 healthy children with other causes than thyroid dysfunction. There was no significant difference between the two groups in the mean values for free triiodothyronine. In the control group, the mean value for free triiodothyronine/free thyroxine ratio was 3. 23. In the congenital hypothyroidism group with a mean value of 2. 5, significantly lower ratios were found than free thyroxine, which was higher relative to free triiodothyronine. In addition, an elevated free triiodothyronine/free thyroxine ratio was observed at higher thyroid stimulating hormone levels due to lower free thyroxine ratios. In children with congenital hypothyroidism and comparison to the control group, the free triiodothyronine/free thyroxine ratio was significantly lower in children with congenital hypothyroidism.
Source link: https://doi.org/10.1530/EC-22-0032
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