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Hypothyroidism - Europe PMC

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Last Updated: 15 September 2022

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The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor.

In juvenile hypothyroid rats, the effect of curcumin on cognitive function, nitric oxide levels, and a brain-derived neurotrophic factor were investigated. The time elapsed and the traveled distance to find the hidden platform in Morris water maze's learning trials increased, and on the investigation day, the number of hours spent in the target quadrant and the distance traveled there was reduced. Hypothyroidism also reduced the latency and increased the time spent in the passive avoidance test's darkroom. Cur improved the rats' results in both MWM and PA tests relative to the hypothyroid group. In hypothyroid rats, Cur also increased the hippocampal production of BDNF. Cur cognitive development in juvenile hypothyroid rats' beneficial results may be attributed to its antioxidant protection against oxidative stress and potentiation of BDNF production.

Source link: https://europepmc.org/article/MED/36094051


Relationship between the development of hyperlipidemia in hypothyroidism patients.

Hypothyroidism has been found to be closely linked to elevated plasma levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, and reduced plasma levels of high density lipoprotein cholesterol, as shown in previous studies. The thyroid hormone, which has been regarded as a key hormone produced and released by the thyroid gland, has been shown to control plasma TC metabolism, on the other hand, although other studies have shown that the thyroid hormone regulates plasma cholesterol levels independently of the TH, which also contributes to hyperlipidemia progression. HT-induced hyperlipidemia and its related cardiometabolic disorders may be attributed to the down-regulated plasma levels of TH and TSH-regulated plasma levels, according to several studies, suggesting that HT may contribute to HT-induced hyperlipidemia and its related cardiometabolic disorders.

Source link: https://europepmc.org/article/MED/36097119


Severe neonatal hyperbilirubinemia secondary to combined RhC hemolytic disease, congenital hypothyroidism and large adrenal hematoma: a case report.

Neonatal hyperbilirubinemia, neonatal sepsis, G-6-PD deficiency, thyroid abnormality, thyroid dysfunction, and hereditary spherocytosis are all possible causes of neonatal hyperbilirubinemia. The father's blood type of Rh was CCDee, according to the mather's ccDEE and CcDEe for the baby, and CcDEe for the child. TSH was 13. 334 millionIU/L at day 10 in the thyroid hormone test. On day 7, which showed hearing impairment, brainstem auditory evoked potential was conducted, which indicated hearing impairment. And if their parents' ABO blood group and Rh are consistent, a Coomb test is recommended for newborns with hyperbilirubinemia due to minor blood group incompatibilities. Any causes should be investigated proactively if bilirubin rises quickly or the clinical therapy effect is poor. To determine if there is adrenal hemorrhage, an abdominal ultrasound should be performed on newborns with palpable abdominal mass, anemia, and jaundice.

Source link: https://europepmc.org/article/MED/36089589


Menorrhagia as main presentation sign of severe hypothyroidism in a pediatric patient: a case report.

The relative high prevalence of menstrual irregularities in the first two-three years after menarche may increase the chance of underestimating related pathological conditions, which must always be thoroughly investigated with careful examination and anamnesis. Low plasma levels of thyroid hormone, according to it, can cause the hemostatic system to a hypocoagulable and hyperfibrinolytic state, resulting in an elevated bleeding risk. This case report details the case of a thirteen year-old girl who presented to our Emergency Department complaining of menorrhagia for the last 15 days, resulting in severe anemia. With the diagnosis of acute hypothyroidism in autoimmune thyroiditis with acquired von Willebrand syndrome, growth hormone deficiencies, and thyroid ultrasound were consistent. Following normalization of coagulative parameters and pituitary hyperplasia, the substitutive therapy with levothyroxine resulted in the cessation of heavy bleeding after five days and a week.

Source link: https://europepmc.org/article/MED/36089580


Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype.

Hypothyroidism is correlated with an elevated risk of cardiovascular disease and increased susceptibility to arrhythmias. Hypothyroidism in an experimental murine model was investigated by our investigators. We analyzed late sodium current in cardiac arrhythmias in an experimental murine model of hypothyroidism. Male Swiss mice were treated with methimazole to cause experimental hypothyroidism before ECG, action potential, and intracellular Ca2+ dynamics were determined. Hypothyroid animals had ECG alterations in the presence of spontaneous sustained ventricular tachycardia, according to the study. The Aberrant AP waveforms were related to increased Ca2+ sparks and out-of-pace Ca2+ waves, according to increased Ca2+ sparks and out-of-pace Ca2+ waves. Animals with hypothyroidism developed catecholaminergic bidirectional ventricular tachycardia through the in-vivo dobutamine + caffeine protocol, but pre-treatment with ranolazine prevented this. Animals with hypothyroidism have an increased susceptibility to developing arrhythmias and ranolazine, a commonly used blocker of INa, are able to alter the arrhythmic phenotype.

Source link: https://europepmc.org/article/MED/36096245


The Impact of Hypothyroidism on Satisfaction with Care and Treatment and Everyday Living: Results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey.

Hypothyroid patients are often dissatisfied with their dissatisfaction and poor quality of life. This report explored the effects of hypothyroidism on patient enjoyment, everyday life, interactions with health care professionals, and the role of demographic and socioeconomic factors. Satisfaction with care and treatment was not related to the type of hypothyroidism therapy. Dissatisfaction was largely due to a lack of confidence and confidence in health care professionals. Respondents receiving levothyroxine alone were more likely to have a positive effect on everyday life than those taking liothyronine-containing drugs. Conclusions: Poor satisfaction with care and treatment for hypothyroidism were strongly connected to a lack of confidence and confidence, as well as negative experiences with health care professionals. Contrary to widespread anecdotes on social media, this large-scale survey finds no correlation between hypothyroidism and patient satisfaction, as well as improved outcomes on everyday life in the context of LT4, as well as improved outcomes on a variety of liothyronine-containing drugs.

Source link: https://europepmc.org/article/MED/35959734


Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism.

Methods A genome-wide DNA methylation analysis was performed on 23 twin pairs, 4 concordant, and 19 discordant pairs for CH at birth. Results Differential methylation analyses showed no difference between CH cases and controls in methylation levels, but a different methylation status of several genes may account for the CH discordance of a monozygotic twin pair carrying a monoallelic nonsense mutation of DUOX2. CH performed priority analysis on the genes epimutated exclusively in the cases identified SLC26A4, FOXI1, NKX2-5, and TSHB as the genes with the highest score.

Source link: https://europepmc.org/article/MED/36071330


Evaluating Statin Tolerability in Historically Intolerant Patients After Correcting for Subclinical Hypothyroidism and Vitamin D Insufficiency.

Aim Our study sought to determine whether or not the change from a lipophilic statin to a water-soluble statin, or correction of subclinical hypothyroidism and/or vitamin D deficiency has raised statin tolerance. Methods We performed a retrospective review of the patient records of our lipid clinic due to statin intolerance. Patients who were allergic to a lipophilic statin were switched to a water-soluble statin. Patients with vitamin D insufficiency/deficiency or hypothyroidism were re-challenged with a water-soluble statin after a diagnosis of the metabolic abnormality. With minimal systemic exposure, 72% of eligible patients, defined as those with a documented metabolic abnormality or no family with a lipophilic statin, were able to tolerate a water-soluble statin or lipophilic statin. Conclusions Our results show that either subthyroidism and/or vitamin D deficiency, as well as the switch from a lipophilic statin to a water-soluble statin improves statin tolerance.

Source link: https://europepmc.org/article/MED/36063342


Iodine-containing ointment-induced hypothyroidism in a patient with anorexia nervosa and sacral decubitus ulcer: a case report with literature review.

We present an example of a 58-year-old woman with anorexia nervosa and a sacral decubitus ulcer who developed hypothyroidism as a result of an iodine-containing ointment. Hypothyroidism is common among patients with autoimmune thyroid disorders who have a high iodine intake. However, anorexia nervosa may have exacerbated the iodine-induced hypothyroidism in our patient. No new study has reported a case of hypothyroidism induced by iodine-containing ointment in a patient with anorexia nervosa.

Source link: https://europepmc.org/article/MED/36058848


The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study.

This study was designed to determine the relationship between proteinuria and hypothyroidism in chronic kidney disease patients. We conducted a cross-sectional study involving 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion and thyroid function testing. According to a Spearman correlation report, 24-h Cr clearance was positively linked to free triiodothyronine, while up was negatively correlated with free triiodothyronine. Hypothyroidism prevalence among participants with higher CKD stage and nephrotic range proteinuria was found by a CKD-based stratified analysis stratified by CKD stage and UP for hypothyroidism.

Source link: https://europepmc.org/article/MED/36056164

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions