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Hypothyroidism - DOAJ

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Last Updated: 15 September 2022

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Secondary hormonal alterations in short-term severe hypothyroidism; in the focus: Apelin and copeptin

paraphrasedoutput:Methods The aim of this prospective observational research was to investigate the intricate interactions of thyroid hormone, apelin, and copeptin in patients with severe transitory hypothyroidism in the fluidu2013ion homeostasis of patients with acute transitory hypothyroidism following surgical removal of the thyroid gland and after appropriate thyroid replacement therapy. paraphrasedoutput:Results: Used ELISA. In the hypothyroid state, apelin levels were lower than previously available lab results, although copeptin and apelin levels did not differ, but copeptin levels were not different from the euthyroid condition. In multivariate linear regression models, copeptin and TSH were both important independent predictors of apelin levels, of which TSH had an explanatory power of 48. 7%. In comparison to copeptin, sodium levels were negatively associated with TSH and positively with ACTH and cortisol. TSH and copeptin are two independent predictors of apelin concentration, of which TSH is higher.

Source link: https://doi.org/10.3389/fendo.2022.981891


Hypothyroidism Induced Hyponatremia: A Case Report

Thyroid hormones have a variety of effects on the body, including electrolyte and water hemostasis. With a serum sodium level of 110 meq/l, we examine a case of a 62-year-old female with the signs of severe hyponatremia like altered mental sensorium. Hypothyroidism's signs of hyponatremia were alleviated on treating hypothyroidism. Therefore, thyroid stimulating hormone testing is necessary during hyponatremia testing.

Source link: https://doi.org/10.31729/jnma.7471


Interplay between polycystic ovary syndrome and hypothyroidism on serum testosterone, oxidative stress and StAR gene expression in female rats

Following the introduction of PCOS, Estradiol valerate caused PCOS, the second group's only PCOS, while the third, fourth, and fifth groups were given different doses of propylthiouracil to cause hypothyroidism. Conclusions Compared to the PCOS group, testosterone levels were noticeably higher in the PCOS group than the control group, and significantly lower in PTU groups compared to the PCOS group, according to radioimmunoassay results. According to the quantitative real-time polymerase chain reaction results, the same results were obtained for the StAR gene as well. Although the oxidant and antioxidant levels in the PCOS group soared along with the placebo group following hypothyroidism, the metabolic load in the hypothyroidism group soared sharply, though the antioxidant level decreased sharply, though the antioxidant level decreased significantly. Conclusions The findings of this research show that the presence of both PCOS and hypothyroidism alters the situation more than PCOS.

Source link: https://doi.org/10.1002/edm2.359


The Overall Prevalence of Hypothyroidism in Children Suffering Chronic Constipation in Shahrekord in 2019

Children with thyroid disorders may be significantly exposed to a higher risk of constipation, according to a risk of constipation; however, the exact cause of this relationship is uncertain. The aim of the study was to determine the incidence of hypothyroidism in children suffering from persistent constipation. Methods: This cross-sectional study was conducted on 380 infants over 30 days old with persistent constipation. The overall hypothyroidism in the study population was estimated to be 4. 2% based on the value of measuring serum TSH and 1. 0% based on serum-free T4 use.

Source link: https://doi.org/10.34172/ijer.2022.24


Evaluation of Etiological Causes of Hypothyroidism among Patients Visiting Specialized Center for Diabetes and Endocrinology

Conclusions: Out of these 217 patients, 129 patients have thyroiditis, and 33 patients have undergone thyroidectomy. Hypothyroidism was found to be a result of chronic autoimmune thyroiditis or chronic thyrotoxicosis in one patient. The findings of this research show an increase in autoimmune thyroid disease linked to the increasing prevalence of type 1 DM, indicating a rising incidence of autoimmunity in young adults.

Source link: https://doaj.org/article/28a77b5e0e604c44a82de5f7ed6309ea


Subclinical Hypothyroidism in Obese Iraqi Patients Attending Obesity Research and Therapy Unit

Objective: To determine the prevalence of subthyroidism in adult obese patients admitted to obesity research and therapy unit ORTU, in AL-Kindy College of medicine, and to investigate the anthropologic and metabolic causes of subthyroidism in adult obese patients presented to ORTU. Method: A retrospective descriptive study of adult obese males and females patients attending ORTU during the period from January 2013 to February 2014, aging 20-60 years. In addition, fasting glucose, total cholesterol, and triglycerides all rise with age in patients with SH. Patients with hypothyroidism and elevated BMI are correlated with significant rise in the mean TSH level in patients with subclinical hypothyroidism.

Source link: https://doaj.org/article/b8b5d40099ea4cafa66639ff9c10d110


The Role of Metformin in patients with Primary Hypothyroidism

The aim of this research was to investigate the effect of metformin in lowering TSH levels in patients with primary hypothyroidism. After 2 months, 36 patients have a normal baseline TSH and no change, and no change after 2 months, while 64 patients have a change in TSH either a decrease or an increase. Conclusion: Metformin therapy is particularly effective in lowering TSH levels in patients with primary hypothyroidism.

Source link: https://doi.org/10.47723/kcmj.v15i1.86


A Comparison between High Ablative Versus Usual Dosages of Iodine-131 in Inducing Hypothyroidism After One Year of Therapy in Hyperthyroid Patients

A number of endocrinologists prescribe an ablative dose, but a predetermined dose appears to be safer than a calculated dose in real life. Object: To test hypothyroidism in hyperthyroid patients one year after RAI surgery, comparing the results of RAI-131's high ablative versus normal dosages. Out of 162 patients in the first group, 11 patients, experienced hypothyroidism, compared to 12 patients in the second group, out of 1212.

Source link: https://doi.org/10.47723/kcmj.v15i2.155


Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders

Objectivities of this research The current research sought to investigate the presence of abnormalities in thyroid-related hormones, lipid profile, and total proteins in the serum of patients with various metabolic disorders. Thyroxin was downregulated in diabetic and symptomatic thyroiditis patients, but it was upregulated in patients with hypertension. In men who were diabetic only, upregulation was regulated, and total protein was downregulated in those with hypotension only. Hypothyroidism in patients with diabetes, acute thyroiditis, and hypertension was correlated with dyslipidemia. Conclusion This research showed a connection between hypothyroidism, dyslipidemia, and total protein in patients with various metabolic disorders.

Source link: https://doi.org/10.1177/03000605221119656


Study of undiagnosed clinical hypothyroidism in patients with obstructive sleep apnea

Introduction The signs of hypothyroidism and obstructive sleep apnea are similar. Patients with OSA should have undiagnosed clinical hypothyroidism. Patients and method The retrospective review was conducted in Kahr Al Ainy Hospital, Cairo University's Chest department, and it included 140 patients diagnosed as obstructive sleep apnea. To all, history research, medical examination, blood tests including thyroid profile, Body measurements, the Epworth Sleepiness scale, polysomnography, and Neck ultrasound were all carried out. Patients were divided into two groups: OSA with euthyroid state and OSA with hypothyroidism. Both groups of neck ultrasound abnormalities had significant differences, with P values less than 0. 001. Although the desaturation index and SpO2 were both higher in the hypothyroid group, the difference did not reach statistical significance. Conclusions The prevalence of clinical hypothyroidism in patients with OSA was 21. 9 percent among our monitored patients.

Source link: https://doi.org/10.4103/ecdt.ecdt_46_21

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions