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Hypothyroidism - Crossref

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Last Updated: 15 August 2022

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Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

In general practice, the aim was to investigate health professional attitudes and perceptions of hypothyroidism management, which contributes to suboptimal treatment of hypothyroidism. The aim of this qualitative interview survey was to conduct semistructured interviews. Conclusions Although health professionals thought hypothyroidism was straightforward to handle, doctors and nurses generally demonstrated an inadequate understanding of drug interactions and levothyroxine pharmacokinetics. Pharmacists felt limited in the information they provide to patients due to a lack of access to patient records. Enablers recommended by health professionals to help with hypothyroidism management included continuity of care, blood test results, system alerts for interfering medications, prescription renewal, and readily available blood tests and levothyroxine prescriptions for patients. Addressing the gaps in patient and professional knowledge and perceptions could eliminate the barriers to optimal care, while continuous care and increased involvement of pharmacists and practice nurses would continue to promote safe thyroid replacement.

Source link: https://doi.org/10.1136/bmjopen-2017-019970


Hypothalamic hypothyroidism and hypogonadism in prolonged traumatic coma

Prolonged coma after head injury is associated with the depletion of 3u2032,5-u2032cyclic adenosine monophosphate in the cerebrospinal fluid, according to u2713. This report examines the pituitary-hypothalamic function in 15 adult male patients with traumatic coma lasting longer than two weeks because cAMP has been implicated in neuroendocrine secretion. Both severity of coma and depletion of CSF cAMP were proportional to 11 patients' level of consciousness fluctuated, with decreased plasma T4 and testosterone decreasing in 11 patients' level of awareness varying. Both endocrine abnormalities in six patients who recovered consciousness recovered consciousness, whether partial or complete, were modified partially or completely. Injection of 1 thyrotrophic-releasing hormone and 2 gonadotrophic-releasing hormone resulted in elevated plasma levels of 1 TSH, 2 LH, and FSH, respectively, indicating a suprahypophyseal deficiency. These results show that suprahypophyseal hypothyroidism and hypogonadism can occur in patients with a chronic coma extending longer than two weeks.

Source link: https://doi.org/10.3171/jns.1978.49.5.0650


Association of hypothyroidism with unruptured cerebral aneurysms: a case-control study

OBJECTIVE Thyroid disease has been shown to influence vascular function and has been associated with aortic aneurysm formation in some cases; however, the link has not been well investigated. Hypothyroidism has been attributed to cerebral aneurysm formation. METHODS (Persecutors) The authors conducted a retrospective case-control study of consecutive patients who had undergone cerebral angiography at an academic, tertiary care medical center in the period from April 2004 to April 2014. Patients with unruptured aneurysms were identified from among those who had undergone 3-vessel catheter angiography. RESULTS Two hundred forty-three patients with unruptured cerebral aneurysms were identified and age matched with 243 controls. According to an adjusted OR of 12. 7 versus a 2. 5 on multivariate analysis, men with hypothyroidism had higher odds of unrupted cerebral aneurysm diagnosis than those with hypothyroidism.

Source link: https://doi.org/10.3171/2016.10.jns161953


Subclinical Hypothyroidism Increases the Requirement of Renal Replacement Therapy After Cardiac Surgery

One of the worst complications after cardiac surgery is acute kidney injury. After isolated coronary artery bypass graft surgery, isolated coronary artery bypass surgery was performed, the aim of the current report was to evaluate the influence of SCH on AKI and the need of renal replacement therapy. Methods: We retrospectively reviewed the prospectively collected records of 336 adult patients who underwent isolated CABG surgery with normal renal function from January 2017 to January 2019. The effect of SCH on AKI and the need for RRT after CABG was determined using logistic regression modeling, and the results were presented as an odds ratio with a 95% confidence interval. In Group I, AKI was seen in 15 patients, in Group I, but there were 42 patients in Group II. Conclusion: The presence of SCH appears to be linked to an elevated risk of AKI and an increased demand for RRT after cardiac surgery.

Source link: https://doi.org/10.1532/hsf.3059


Impact of Overt Hypothyroidism on Early Outcomes of Coronary Artery Surgery

Background: It's unclear if there is a correlation between preoperative overt hypothyroidism and early outcomes after coronary artery bypass grafting. These patients were 1:4 matched with 737 euthyroid patients using propensity score matching, with a propensity score matching technique. Result: After propensity score matching, the prevalence of impaired wound healing, reintubation, and total complications among hypothyroid patients were greater than those in euthyroid patients. Hypothyroid patients' proportions were higher than euthyroid patients. Hypothyroid patients' duration of inotropic assistance and mechanical ventilation were longer than euthyroid patients.

Source link: https://doi.org/10.1532/hsf.4057


Evaluation of recombinant human thyroid-stimulating hormone to test thyroid function in dogs suspected of having hypothyroidism

Animals of the United U201464 breeds with clinical signs of hypothyroidism are among hypothyroidism in the United States. For determination of total serum thyroxine concentrations, blood samples were collected before and 6 hours after the rhTSH administration's administration was determined. In prestimulation serum, a serum canine TSH level was determined. Basal T4 and post-TSH T 4 concentrations were significantly different in both groups. Hypothyroid and 1 hypothyroid dogs could have been misinterpreted as hypothyroid and euthyroid, respectively, on the basis of basal serum T4 and cTSH levels alone. Prior to the test, nine of the 15 dogs with intermediate post-TSHT 4 levels had been prescribed to influence thyroid function, and two of them had severe nonthyroid disease. u2014's conclusion and clinical relevance TSH-stimulation test with rhTSH is a useful diagnostic tool to determine thyroid function in selected dogs in which a diagnosis of hypothyroidism cannot be based on basal T4 and cTSH concentrations alone, which cannot be based on basal T4 and cTSH levels alone.

Source link: https://doi.org/10.2460/ajvr.67.12.2012


Diagnosis and Treatment of Primary Hypothyroidism in Primary Care

In the general population, 0,2 percent of men and 1,4u20135 percent, respectively, and among people over 60 years old, 2,5 percent of men and 6% of women. The reason for testing the patient for thyroid hormone levels in primary care is nonspecific clinical manifestations of hypothyroidism. Decreased thyroid function may have subclinical and apparent forms, which can be identified in the review of thyroid hormone levels and clinical signs of the disease, and may need different treatment strategies. Patients of various ages and depending on the cause of hypothyroidism, there are differences in the use of levothyroxine replacement therapy in patients of various ages and depending on the source of hypothyroidism. The example of four clinical cases illustrates how the dose and terms of levothyroxine sodium prescription in primary care are presented. In patients with primary hypothyroidism, the control levothyroxine replacement therapy is also described.

Source link: https://doi.org/10.30841/2307-5112.1-2.2022.260508


Cancer-specific mortality in breast cancer patients with hypothyroidism: a UK population-based study

Abstract Purpose Epidemiological studies have found a higher prevalence of hypothyroidism in breast cancer patients, possibly due to shared risk factors and breast cancer treatment. Methods We conducted a population-based survey using the Scottish Cancer Registry to identify women diagnosed with breast cancer between 2010 and 2017. Hypothyroidism diagnosed before and after breast cancer therapy was discovered, along with breast cancer-specific and all-cause mortality using hospital diagnoses and dispensed prescriptions for levothyroxine. Results An total of 33,500 breast cancer patients were identified, of which 3,802 had hypothyroidism before breast cancer diagnosis, and 565 patients went on to experience hypothyroidism after. Compared to cancer-free controls, breast cancer survivors had higher rates of hypothyroidism than those without. Conclusion in a large contemporary breast cancer cohort, there was no evidence that hypothyroidism, whether at diagnosis or post-brain cancer, was associated with cancer-specific or all-cause mortality.

Source link: https://doi.org/10.1007/s10549-022-06674-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions