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Our objectives were to investigate the effects of melatonin treatment of mice lacking endogenous pineal melatonin in the light and dark phases, and on the effects of mice with a targeted deletion of the MT1 melatonin receptor. In both C57WT and C57MT1KO groups, mice were shown to have hypokinetic effects by fluphenazine treatment during the dark phase of a light environment. According to these findings, fluphenazine-induced hypokinesia is more evident under light than under dark conditions, and that melatonin is only able to treat hypokinesia during the light phase. The effect of melatonin on hypokinesia was not solely mediated by the MT1 melatonin receptor in the C57BL/6 mouse, not solely mediated by the light/dark environment, according to our results.
Source link: https://europepmc.org/article/MED/35248650
Objects The present paper investigated the stability of furosemide under space-flight conditions onboard the International Space Station, as well as its pharmacokinetics and pharmacodynamics under conditions simulating exposure to several space-flight factors. A statistically significant rise in the stroke volume in ANOH conditions 6 hours after furosemide administration, as well as decreasing of total peripheral resistance in compared to baseline. Conclusions It has been found that various aspects of space flight do not significantly influence the stability of furosemide in tablet form after six months of storage on board the International Space Station.
Source link: https://europepmc.org/article/MED/35218179
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