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However, the mechanism by which hyperthyroidism leads to cognitive dysfunction by a synaptic pathway remains unknown. In an animal model that involved repeated injections of triiodothyronine, we investigated the synaptic mechanisms involved in the consequences of hyperthyroidism in an animal model. These mice demonstrated decreased learning and memory in the Novel object recognition exam, Y-maze test, and Morris Water Maze, as well as increased fear in the elevated plus maze. The number of AMPA- and NMDA-type glutamate receptors in the hippocampus was drastically reduced in the hippocampal CA1 region of hyperthyroid mice, as a result of reduced levels of AMPA- and NMDA-type glutamate receptors in the hippocampus. In primary cultured hippocampal neurons, T3- and NMDA-type glutamate receptor expressions were also reduced, and whole-cell patch-clamp recording showed that excitatory synaptic function had clearly decreased after T3 treatment.
Source link: https://doi.org/10.1016/j.nbd.2022.105807
In the TSHR gene mutation database, only 41 families have reported so far, with 41 families registering so far. We present the clinical and genetic characteristics of 11 patients with FNAH over four generations of a Slovenian family. p. Met453Valu unknown TSHR variant was found to be pathogenic, and all patients had a novel heterozygous TSHR variant NP_ 000360. 2: p. Met453Valuable and pathogenic. Our experience with this multi-generation family in FNAH has shown the need for early diagnosis and appropriate management of FNAH.
Source link: https://doi.org/10.2478/bjmg-2020-0022
The impact of antithyroid drugs on the therapeutic efficacy of radioactive iodine in hyperthyroidism is still tense. The aim of this research was to determine the effects of ATD withdrawal on the therapeutic efficacy of I-131 in hyperthyroidism patients receiving long-term ATD therapy. The subjects were divided into three groups: group I had been using ATDs for more than a year and stopped more than three days; group II had been using ATDs for more than a year but stopped for three days or less; and group III had never been using any ATD before radioactive iodine therapy. After three months of radioactive iodine therapy for group I and group II, group II, and group III, but not between group I and group III, there was a significant change in the therapeutic effectiveness, but not between group I and group III.
Source link: https://doi.org/10.4103/1450-1147.167584
Graves'u2032 ophthalmopathy occurrence in GD after radioiodine thyroid ablation. With time, the TRAb values gradually degraded, and patients with a positive outcome had a lower TRAb value than those with treatment failure. For the first time in five patients who were successfully treated for hyperthyroidism, GO showed an early and persistent period of hypothyroidism, despite an anti-thyroid drug intolerance and high TRAb level. On the basis of this research's findings, we conclude that ablative RIT is safe in eradicating Graves'/2032 hyperthyroidism, but that it can be accompanied by GOSH, particularly in patients with early hypothyroidism and high pretreatment TRAB and/or ATD intolerance.
Source link: https://doi.org/10.4103/1450-1147.98731
Since patients with severe cerebral venous sinus thrombosis, a proper treatment strategy should be initiated as soon as possible because they will quickly deteriorate. Case presentation In this case study, a 32-year-old Mongoloid woman admitted to progressive headache, impaired cognition, and right limb weakness, and was diagnosed with cerebral venous sinus thrombosis caused by hyperthyroidism. Conclusions: If patients with hyperthyroidism suffer from headache, progressive impairment of consciousness, seizures, and other signs, the presence of cerebral venous sinus thrombosis should be investigated and appropriate tests should be carried out as soon as possible. If conventional therapy struggles, cerebrovascular intervention may be a safe and cost-effective option for patients with severe cerebral venous sinus thrombosis.
Source link: https://doi.org/10.1186/s13256-022-03463-y
However, new research into the effects of propylthiouracil on maternal or foetal are mixed. For binary variables, the Odds ratio and 95% confidence interval were used for binary variables, weighted mean difference, and 95% confidence interval were used for continuous variables. Compared to the control group, the propylthiouracil group's serum indices were significantly lower than those in the control group. Conclusions This meta-analysis confirmed the beneficial effects of propylthiouracil therapy, namely, the chances of adverse pregnancy outcomes were not increased, but it also demonstrated PTU's effectiveness in the treatment of pregnant women with hyperthyroidism. The results pointed to the use of propylthiouracil in pregnancy with hyperthyroidism in order to improve clinical pregnancy outcomes in patients with thyroid dysfunction.
Source link: https://doi.org/10.1371/journal.pone.0265085
Pancreatitis caused by methimazole -induced pancreatitis is illustrated here. To our knowledge, this is the sixth case reported in the literature and the first reported in a patient with a toxic multinodular goiter. MMI 10 mg orally every day was started by a 51-year-old Caucasian female with a history of benign multinodular goiter and subthyroidism. Abdominal computed tomography revealed acute uncomplicated pancreatitis, but there were no evidence of gallstones or tumors. MMI 10 mg orally every day was restored to normal life. Her lipase was raised 12 times over the upper limit of normal, and abdominal computed tomography was once more compatible with acute uncomplicated pancreatitis. The patient is currently considering definitive therapy with radioactive iodine ablation. Our case, as well as recent case reports in the literature, may raise concerns about the possibility of pancreatitis in patients with MMI in the presence of unusual signs.
Source link: https://doi.org/10.1177/2324709615592229
It may be a sign of any inflammatory process of the thyroid as well as a defining feature of thyroid storm. Diabetes mellitus is the commonest co-morbidity observed in India, and it is caused by the gram negative bacterium Burkholderia pseudomallei. Here we review a case of Graves disease that was referred to by a primary care physician with a history of persistent fever for more than a month and then diagnosed as melioidosis.
Source link: https://doi.org/10.4103/jfmpc.jfmpc_933_19
Thyroid uptake scans and ultrasonography aid in determining hyperthyroidism, particularly when thyroid receptor antibody measurement is not readily available. In addition, the inappropriate use of thyroid scanning in various thyroid diseases was investigated. Patients with Gravesu2019 disease were typically younger, used carbimazole during both the biopsy and scan, had an increased thyroid gland, and had higher FT4 and FT3 measurements, compared to toxic solitary/multinodular goiter. In about 10% of patients, inappropriate thyroid uptake and scan use were documented, and 25% of the patients used carbimazole during the uptake and scan.
Source link: https://doi.org/10.1186/s13104-020-05164-5
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