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Hydrogen - U.S. Department of Veterans Affairs

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Last Updated: 18 July 2022

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Characterization of hydrogen sulfide toxicity to human corneal stromal fibroblasts.

Hydrogen sulfide gas is both a chemical weapon and a common environmental pollutant. Vision loss can be caused by eye contact. We present H2 S-induced cytotoxicity and the parameters contributing to corneal toxicity using primary human corneal stromal fibroblasts in vitro, but the cellular mechanisms underlying corneal damage remain uncertain, and no specific therapy exists to reduce ocular damage from H2 S. As a source of H2 S, sodium hydrosulfide was used as a source of H2S, and H2 S' cytotoxicity was determined by treating hCSF cells with varying amounts of NaSH for 0-72 hours. NaSH's IC50 was found to be 5. 35 mM. In hCSF cells, a NaSH 5. 35 mM exposure resulted in significantly reduced cytochrome c oxidase activity, increased ROS production, and a rise in the expression of inflammatory and fibrotic genes.

Source link: https://doi.org/10.1111/nyas.14498

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions