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Hydrogen sulfide gas is both a chemical weapon and a common environmental pollutant. Vision loss can be caused by eye contact. We present H2 S-induced cytotoxicity and the parameters contributing to corneal toxicity using primary human corneal stromal fibroblasts in vitro, but the cellular mechanisms underlying corneal damage remain uncertain, and no specific therapy exists to reduce ocular damage from H2 S. As a source of H2 S, sodium hydrosulfide was used as a source of H2S, and H2 S' cytotoxicity was determined by treating hCSF cells with varying amounts of NaSH for 0-72 hours. NaSH's IC50 was found to be 5. 35 mM. In hCSF cells, a NaSH 5. 35 mM exposure resulted in significantly reduced cytochrome c oxidase activity, increased ROS production, and a rise in the expression of inflammatory and fibrotic genes.
Source link: https://doi.org/10.1111/nyas.14498
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