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Huntington's Disease - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 11 January 2022

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Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington's disease.

Aggregation of proteins is a famous trademark of basically all neurodegenerative problems consisting of Alzheimer's, Parkinson's and Huntington's diseases. Here, we present a label-free, laser-based photothermal treatment of polyglutamine aggregates in a C. elegans nematode model of huntingtin-like polyQ aggregation. The results obtained demonstrate that our theranostics platform, incorporating photothermal treatment without drugs or other chemicals, combined with advanced imaging to monitor photothermal ablation of accumulations, launches systemic recovery and therefore validates the idea of aggregate-disruption treatments for neurodegenerative diseases in people.

Source link: https://doi.org/10.1038/s41598-021-98661-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions