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According to the prevailing metabolic state, [1-13C]pyruvate cardiovascular magnetic resonance imaging can demonstrate the uptake and intracellular transformation of [1-13C]pyruvate to either [1-13C]lactate or 13C]bicarbonate. The aim of the present research was to evaluate cardiac metabolism in the healthy human heart at rest and under moderate stress by combining an adenosine stress test with HP [1-13C]pyruvate CMR. CMR and HP [1--13C]pyruvate CMR at rest and during adenosine stress was demonstrated by Healthy human subjects. To compare mean values at rest and during stress, Paired t-tests were used. Conclusions Adenosine stress testing in combination with HP [1-13C]pyruvate CMR is safe and well tolerated in healthy subjects. During cardiac distress, we noticed an increase in pyruvate oxidation. The new research is a major step forward in the translation of HP [1-13C]pyruvate CMR into clinical cardiac imaging.
Source link: https://doi.org/10.1186/s12968-022-00860-6
"Many drugs interact with ion channels in the cells of our heart's cells and cause heart rhythm disorders with potentially lethal consequences. " For the example of the drug dofetilide, we show that drug concentrations of 5x and 8x elevate the heart rate to 122 and 114 beats per minute, increase myofiber stretches by 5%, and reduce overall tissue relaxation by 6%. Knowing how different drug concentrations influence the heart's results has significant medical implications in drug safety analysis and personalized medicine. ".
Source link: https://doi.org/10.1007/s00466-022-02146-1
"We used immunohistochemical staining to determine BRG1 expression in 796 human cardiac samples and identify elevated BRG1 expression in human fetal hearts during early development. " In addition, we did not only witness an increase in the expression of BRG1 in HCM, but we also discovered that other illnesses that lead to heart failure have similar BRG1 expression to healthy controls. BRG1 inhibition in human induced pluripotent stem cell-derived cardiomyocytes significantly reduces MYH7 and raises MYH6 in human induced MYH7, boosting MYH6 and raising MYH6, raising BRG1's regulatory role in the two myosin heavy chain isoforms in human HCM's pathological imbalance.
Source link: https://doi.org/10.1038/s41598-022-11829-x
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