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Human Brain - U.S. Department of Veterans Affairs

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Last Updated: 11 December 2022

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Population-level variation in enhancer expression identifies disease mechanisms in the human brain.

Enhancers' ability in the human brain can be determined by population-level variability. We investigated gene-enhancer cooperation and found that enhancer-linked genes are strongly linked to neuropsychiatric disease. Enhancer eQTLs mediate a significant proportion of neuropsychiatric trait heritability, according to us, expression quantitative trait loci for both genes and enhancers, which found that enhancer eQTLs mediate a significant proportion of neuropsychiatric trait heritability. Overall, our report investigates the gene-enhancer regulome and genetic functions in the human cortex in both healthy and diseased states.

Source link: https://doi.org/10.1038/s41588-022-01170-4


Human brain activity and functional connectivity as memories age from one hour to one month.

According to memory consolidation studies, brain regions and connectivity between brain regions can change as memory age. To investigate these neural shifts more closely, we investigated memory and fMRI images for photos of indoor and outdoor scenes from four time periods. Memory accuracy, confidence ratings, and reaction times changed with memory age. Brain activity in a large cortical network increased or decreased with memory age, according to memory age, while hippocampal activity was not related to memory age. These results were almost identical when behavioral shifts across time periods were minimized. As memory age, the functional connectivity of the ventromedial prefrontal cortex and the posterior parietal cortex intensified. By contrast, functional connectivity of the hippocampus with the neural cortex and fusiform gyrus slowed with memory age. With memory age, we found improvements in cortical function and changes in hippocampal and cortical connectivity with memory age.

Source link: https://doi.org/10.1080/17588928.2021.2021164

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions