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Hypomyelination with brainstem and spinal cord involvement, as well as leg spasticity, is a condition that affects the brain and spinal cord. HBSL is a special form of leukodystrophy, which is a group of disorders that involve abnormalities of the nervous system's white matter. The white matter consists of nerve fibers coated by a fatty substance called myelin that protects the fibers and aids in the rapid transmission of nerve impulses. The nervous system in HBSL has a reduced tendency to produce myelin. Early motor skills development in HBSL may be normal, but mobility issues generally begin within the first year of an infant's first year. Muscle brute in the legs that worsens over time is a characteristic of HBSL. Most people with HBSL are unable to walk independently. Using magnetic resonance imaging, subtle changes in the brains of people with HBSL can be detected.
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