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Human Brain - DOAJ

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Last Updated: 11 January 2023

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The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease

In AD patients' frontal cortex, the ratio between their mature and precursor forms was higher than age-matched controls. A lower prevalence of OXPHOS complexes I, III, and V in AD patients compared to controls was also found, as well as a positive correlation between GDF15 and IL-6 mRNA levels was observed. Discussion:However, when GDF15 was silenced in vitro in dermophiles' embryon cells, a rise in IL-6 levels and an increase in IL-6 levels were observed. The conclusion is that although GDF15 appears not to be a good CSF marker for AD, it is commonly expressed in aged and AD brains, most likely as part of a stress response aimed at combating mitochondrial dysfunction and neuroinflammation.

Source link: https://doi.org/10.3389/fnagi.2022.1058665


Genetic variations within human gained enhancer elements affect human brain sulcal morphology

One of the most notable changes in the human brain's evolution is the development of the cerebral cortex. The emergence of our capacities for high-order cognitive skills may have been aided by cortical expansion and cortical folding increases. More than 18,000 participants from the UK Biobank investigated the contributions of genomic annotations spanning 30 years to human sulcal morphology measured via MRI in this research.

Source link: https://doi.org/10.1016/j.neuroimage.2022.119773


Sexual differences of human brain

Prenatal sex hormones and their organisational impact on brain and behaviour are the most common reason for this dimorphism. However, there have been recent and recent calls for hormoneu2019s generational roles in puberty, as well as the effects of genomic imprinting. In this paper, we discussed the sex differences of brain, the available evidence for potential determinants of these differences, as well as the methods that have been used to find them. Based on Magnetic Resonance Imaging results, we reviewed the most important findings with particular attention to macro-anatomical relationships.

Source link: https://doi.org/10.17463/RCM.2014.02.003


Collaborating neuroscience online: The case of the Human Brain Project forum.

This paper examines user interactions on the Human Brain Project's public-access online forum to find the benefits of the Forum for collaborative problem solving. On the HBP Forum, we gather novel data from discussion forum posts and detailed user profiles. HBP Forum usage is similar to that of a leading general-interest coding platform, and online usage metrics have quickly recovered after the initial Covid-19-related dip. User interactions on the Forum are more frequent for questions regarding scripting and in HBP's key areas, according to the results of a regression study.

Source link: https://doi.org/10.1371/journal.pone.0278402


Functional Connectome of the Human Brain with Total Correlation

As a multivariate alternative to traditional pairwise measures such as correlation or mutual information, new studies suggested the use of Total Correlation to establish functional connectivity among brain regions as a multivariate alternative to traditional pairwise measures such as correlation or mutual information. When compared to ground truth values, CorEx's estimates of Total Correlation and clustering results are trustworthy. And finally, we show how the connectivity graphs based on Total Correlation can also be a useful device in the diagnosis of brain disorders.

Source link: https://doi.org/10.3390/e24121725


The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research

Both the passive and active brain have Alpha oscillations as the typical rhythm. According to translational studies, aberrant alpha activity has been implicated in the onset of symptomatologic disorders such as autism, schizophrenia, major depression, and Attention Deficit and Hyperactivity Disorder. For each neuropsychiatric disorder, a separate section will be published, including a brief overview of the most recent findings and scientific contributions published during the last decade.

Source link: https://doi.org/10.3390/biomedicines10123189

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions