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Human Brain - DOAJ

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Last Updated: 11 September 2022

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Easily automated radiosynthesis of [18F]P10A-1910 and its clinical translation to quantify phosphodiesterase 10A in human brain

P10A-1910, [18F]P10A-1910 was a promising radioligand for use in imaging phosphodiesterase 10A in our previous work. We're proud to announce the first automatic cGMP-level [18F]P10A-1910 and translational PET/MRI research in living human brains. [18F]P10A-1910, a GE TRACERlab FX2N synthesis module, was delivered by two different methods. The P10A-1910 was derived from a heating spirocyclic ylide in a tetra-n-butyl ammonium methanesulfonate solution devised by a tetra-n-butyl ammonium methanesulfonate solution, according to [18F] Following formulation, the boronic pinacol ester, as well as copper and oxygen, provided the radioligand with 16. 8 % n. d. c. and 77. 3 bcmol MAs. PDE10A-P10A-1910 was discovered in the order of cerebellum, significant n. . . . , caudate, and putamen, according to a consistent pattern with the PDE10A in the brain. These findings, taken together, show that a static scan protocol could be performed for PET imaging of PDE10A.

Source link: https://doi.org/10.3389/fbioe.2022.983488


Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening

Clinical trials are the primary basis for clinical diagnosis of human disease in animal models, and animal research is mainly based on biomedical research. Animal models have unquestionably contributed to increasing knowledge of human disease pathophysiological and pathophysiological research. Despite a lack of spatial data, none of the existing animal models could accurately simulate human organs and systems' growth due to a lack of spatial information; in contrast, the discrepancy between animals and humans hinders detailed research. For example, animal experiments in human fragile X syndrome solely based on animal models have failed, as mGluR5 antagonists. Organoids isolated from stem cells contribute to a greater understanding of this research. To reproduce human organs' growth in vitro biomedical studies more faithfully and efficiently translate in vitro biomedical studies to clinical trials. Organoids are a miniaturized version of an organ made in vitro, partially recapitulating key characteristics of human organ growth. Organoids' invention has led to a revolutionary breakthrough in regeneration medicine. Organoid-derived human tissue or organs can potentially act as vital platforms for biomedical research, pathological diagnosis of human diseases, and drug testing. The majority of these human organoids have been used for in vitro biomedical research and drug screening. In addition, the challenges and shortcomings of modeling late onset NDDs such as AD and PD are addressed, as well as future perspectives on human brain organoids.

Source link: https://doi.org/10.1155/2022/2150680


Genome-wide association study of the human brain functional connectome reveals strong vascular component underlying global network efficiency

Abstract Complex neural networks play a vital role in integrating activity in the human brain, and in the absence of external stimulation, such networks can be identified. In up to 36,150 participants of the UK Biobank, we carried out ten genome-wide association studies of resting state network measures of intrinsic brain function. RSFA itself had a significant genetic component, and we discovered 24 genomic loci associated with RSFA, 157 genes whose prediction was correlated with it, three proteins in the dorsolateral prefrontal cortex, and four in plasma.

Source link: https://doi.org/10.1038/s41598-022-19106-7


Monitoring the Impact of Spaceflight on the Human Brain

The use of brain monitoring techniques developed on Earth in pre/post-spaceflight scientific protocols has been valuable in determining the effects of space travel on the brain to date. However, future deep space travel will require some brain function monitoring devices for evaluating and monitoring brain health during spaceflight. Here, we discuss the impact of spaceflight on the brain, the basic principles behind six brain function analysis techniques, their current use in spaceflight, and their potential for use during deep space exploration.

Source link: https://doi.org/10.3390/life12071060


Neurocartographer: CC-WGAN Based SSVEP Data Generation to Produce a Model toward Symmetrical Behaviour to the Human Brain

Brain/u2013computer interfaces are an emerging field of medical science that allows users to control external digital equipment using brain activity. Steady-state evoked potential is a form of electroencephalogram signal that is commonly used for brain and mouse interface applications. This work suggests a class-conditioned Wasserstein generative adversary network with a gradient penalty loss for electroencephalogram data generation. After averaging for 100 years with 25 batches of 4 s steady-state-evoked potential results, the resulting model mimics the key stable-evoked future capabilities.

Source link: https://doi.org/10.3390/sym14081600


“Paralympic Brain”. Compensation and Reorganization of a Damaged Human Brain with Intensive Physical Training

The main aim of the research was to determine how the brain of a Paralympic athlete with significant disability due to cerebral palsy has reorganized after continued training geared to improve performance. The affected hand motor cortical area was clearly increased by the cortical representation region, with cortical blood stimulation of the target muscle evidently enhanced, showing that the affected side finger muscle cortical representation area was more prominent than that on the intact side, 6. 11 mV, instead of 0. 39 mV.

Source link: https://doi.org/10.3390/sports8040046


A Generative Network Model of the Human Brain Normal Aging Process

Functional brain age process modeling is indispensable for the discovery of hypothesized generative mechanisms for human brain networks throughout one’s lifespan. To create artificial brain networks and identify human functional brain variations throughout human life, we use LNBE, as well as published generative network models to simulate the aging process of the functional brain network in order to generate neural network networks and explore human functional brain evolution through human lifespans. We are confident that early warnings of latent injury or disease are used today and advance healthcare have the ability to change the way in which brain normal aging process modeling studies are used today and advance healthcare.

Source link: https://doi.org/10.3390/sym12010091


K-th Nearest Neighbor (KNN) Entropy Estimates of Complexity and Integration from Ongoing and Stimulus-Evoked Electroencephalographic (EEG) Recordings of the Human Brain

The difference between stimulated and evoked EEG signals and replicating previous wakeful EEG results obtained using Gaussian-based entropy estimators was evidently different between induced and evoked EEG signals and simulated previous wakeful EEG results. Absolute values of I and CI were linked to absolute levels of alpha-range EEG power and phase synchronization, according to absolute levels of alpha-range EEG power and phase synchronization, but stimulus-related changes in the information-theoretic and other EEG measurements remained stable. These findings support the argument that visual perception and ongoing wakeful mental states result from tangled, dynamical communication among segregated and integrated brain networks operating near an optimal balance between order and disorder.

Source link: https://doi.org/10.3390/e21010061


Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro

Cell-surface proteins that can endocytose into brain microvascular endothelial cells are promising candidates for receptor-mediated transcytosis across the blood-brain barrier. The human brain microvascular endothelial cells were selectively internalized into human brain microvascular endothelial cells, but not into human umbilical vein endothelial cells, a model of human peripheral microvascular endothelial cells. Using open mRNA and protein databases, two cell-surface proteins, intercellular adhesion molecule-1 and podocalyxin, were identified as BBB-localized endocytic cell-surface proteins in humans. PODXL expression in the plasma membrane of hCMEC/D3 cells was confirmed by immunohistochemical analysis, which reported that anti-PODXL antibody-labeled cell-surface PODXL internalized into hCMEC/D3 cells. In conclusion, our results include novel endocytic cell-surface proteins capable of internalizing into human brain microvascular endothelial cells. Targeted antibodies or ligand-labeled biopharmaceuticals and nanocarriers may be able to be delivered to the brain by the BBB or PODXL targeted antibody or ligand-labeled biopharmaceuticals and nanocarriers in the treatment of central nervous system diseases.

Source link: https://doi.org/10.3390/pharmaceutics12060579


Human Brain Networks: Spiking Neuron Models, Multistability, Synchronization, Thermodynamics, Maximum Entropy Production, and Anesthetic Cascade Mechanisms

The neuron's basic building block of the central nervous system, u201d, can be thought of as a dynamic component that is u201citable and can cause a pulse or peak whenever the electrochemical potential across the neuron's cell membrane exceeds a threshold. A key contribution of nonlinear dynamical systems theory to the neurosciences is to investigate the inner nervous system's irregular transitions between macroscopic states. Under asymptotically changing inputs or system parameters, the solutions of a dynamical system will switch between two or more mutually exclusive Lyapunov stable and convergencent equilibrium states. From a multistable dynamical system perspective, the results are then applied to excitatory and inhibitory neuronal networks to describe the underlying mechanism of anesthesia and consciousness from a multistable dynamical system perspective, providing a theoretical basis for general anesthesia using the brain's network properties.

Source link: https://doi.org/10.3390/e16073939

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions