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Human Brain - ClinicalTrials.gov

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Last Updated: 11 September 2022

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Reliability Of The Human Brain Connectome

Secondary goals include investigating the human brain connectome's dynamic properties and energy requirements, as well as the effects of physiologic noise, gender, and age on measures of brain function at rest and during task performance. Plans: Participants will have two MRI/MRS sessions to determine test-retest quality of FC at rest and during task success, as well as during job performance, and one 18F-Fluorodeoxyglucose -PET session to investigate the connection between FC and glucose metabolism in the human brain.

Source link: https://clinicaltrials.gov/ct2/show/NCT02193425


Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness

OBJECTIVES: The primary aim is to see if there is an increase in the apparent diffusion coefficient in the human brain during sleep when compared to the awake state, and to determine if they differ across brain regions. The scan taken before falling asleep and those taken shortly after waking up will also determine if ADC changes with sleep are related to subjective perception of rested sleep and determine if there are differences in T1 in CSF between the scan taken shortly after awakening and those taken immediately after awakening. We request permission to recruit up to 20 healthy volunteers in order to determine the best MR parameters and pulse sequence for optimal ADC signal detection. The primary and secondary outcomes that were not expected above are included in both research Phase I and data Phase II, as well as the main and secondary outcomes expected above. Only if we show that ADC significantly improves during sleep compared to the awake state will we progress to phase II. Following two night stays to measure brain ADC, the participants will spend three nights in the medical center and two hours while asleep, one while awake and the other while asleep. For the first of the three nights we will simultaneously record the electroencephalogram and ECG of the participants while sleeping, which will enable us to correlate the ECG to their EEG results, which is the gold standard for measuring sleep.

Source link: https://clinicaltrials.gov/ct2/show/NCT02311374


Regenerating the Adult Human Brain Through Exercise

Neurogenesis studies in healthy and dementia patients have only been conducted on postmortem tissue, which prevents investigation of treatment outcomes. Patients with mesial temporal lobe epilepsy are less likely to prescribe medications and, in particular, those with dementia disorders receive corrective surgical therapy, giving researchers with a rare opportunity to investigate the benefit of regenerative interventions on hippocampal electrophysiology and neurogenesis. Ten people with MTLE who are recommended for surgical care as part of their standard care will be enrolled and randomly assigned to High Impact and Low Impact exercise groups. The duration of exercise programs will be 12 weeks, and study arms will follow the same protocol except for the target heart rate, which will be higher in the High-Impact group.

Source link: https://clinicaltrials.gov/ct2/show/NCT05179083


"Long COVID-19" on the Human Brain

2 people newly diagnosed with COVID-19 without CNS-PASC symptoms within six months of recovery, 2 people who were previously infected with COVID-19 with CNS-PASC central nervous system within 6 months of diagnosis, 2 others not previously infected with COVID-19 without CNS-PASC-PASC symptoms within 6 months of diagnosis, and 3 a control group of people not previously infected with COVID-19 were not previously infected with COVID-19 Participants that satisfy the inclusion and exclusion requirements at the initial screening visit 1 and give written permission will be admitted to the study. Participants that meet the inclusion and exclusion criteria at the first screening visit 1 and provide written permission will be admitted to the registry. Participants will perform PET scans with the innovative PET tracer [18F]SDM-8 to determine synaptic density measurements. Participants in four research visits at defined time points during their enrollment process, including the first participant screening visit 1. On visits 2, 3 and 3, two brain imaging scans and PASC/cognitive assessments will be conducted, as well as a subsequent PASC/cognitive assessment report at visit 4, which takes place just over two months after Visit 3.

Source link: https://clinicaltrials.gov/ct2/show/NCT05433324


Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Proton MRS and phosphorous MRS are two common spectroscopy techniques to measure metabolism in vivo. P MRS can be used to determine energy phosphate metabolites of inorganic phosphate, phosphocreatine, adenosine diphosphate, and adenosine triphosphate in brain and muscle. To analyze metabolites in human brain and muscle, we first, to apply and optimize current proton and P MRS techniques developed in the literature. MRS data can be exchanged with other studies in order to provide data analysis and quality control for the experiments conducted under this, other NIH, or outside protocols. MRS scan time will be anywhere from one to two hours long. We expect to see high-quality proton and/or phosphorous spectroscopy imaging from healthy volunteers, which may help develop precise and reliable spectroscopy techniques for clinicians and other disorders in human brain or muscle.

Source link: https://clinicaltrials.gov/ct2/show/NCT01266577


Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy

The use of regional cerebral oximetry as a measure of true cerebral oxygenation is controversial due to extracranial signal contamination and unmeasured confoundment of cerebral a:v ratios. In uninjured, normal human brain, we investigate the possibility of a correlation between PbrO2 and rSO2 under conditions of varying inspired oxygen fraction and the presence of variable partial pressure of carbon dioxide in arterial blood. Following written informed consent obtained by a study team member during their preoperative evaluation, patients who are scheduled for elective removal of secondary cerebral metastases under general anesthesia will be recruited. During a pause in surgery, FIO2 and minute ventilation will be gradually adjusted to achieve the following two ventilation set points: 1 FIO2 0. 3 and paCO2 30mmHg, 2 FIO2 1. 0, and paCO2 40mmHg.

Source link: https://clinicaltrials.gov/ct2/show/NCT03128957


How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery of Children With Cerebral Palsy and Typically Developed Children (Control).

Cerebral palsy is a motor disorder characterized by an immature brain injury. Even though the brain damage doesn't change, children with CP will have increasingly weaker, shorter, and stiffer muscles that could lead to contractures, bony deformations, difficulty walking, and decreased manual ability. Pro-inflammatory cytokines and the cytoprotective polypeptide humanin will be measured and correlated to the amount of humanin found in muscle. The mechanism of contracture formation will hopefully be identified with this compound information, as well as prevention of hip dislocation and general health, which may include hip replacement and general health. CP is caused by the formation of contracture in CP by: the strefer muscle/tendon complex, according to research. Is there any extracellular matrix around the muscle fiber bundles in CP? U2022 Blood samples: Will there be an increase in the synthesis of pro-inflammatory cytokines related to increased blood flow in muscle and muscle pathology? Is humanin levels in plasma linked to muscle mass? Muscle samples and tendon samples will be obtained during clinically advised and planned orthopaedic surgery from muscles that are easily identifiable from the incisions used for primary surgery. Muscle samples 3x3x8 mm from 2-8 different muscles will be obtained in such a way that there will be no diminished clinical function. Muscle biopsies from the upper limb can be compared to muscle biopsies from the lower limb that are used in more or less automated gait, as muscles in the upper limb are used more often and irregularly.

Source link: https://clinicaltrials.gov/ct2/show/NCT05506228


Brain Networks in Dystonia

The emergence of this gap is an important issue because it leaves us unable to distinguish between primary and secondary brain changes that contribute to the tsPFD pathophysiology and the development of novel treatment strategies focusing on disorder-specific brain alterations. The aim of this essay is to establish the brain circuits underlying the phenomenon of task specificity in two representative groups of patients with author's cramp vs. musician's cramp vs. singer's spasmodic dystonia and spasmodic dystonia, as well as quantitative neuropathology of postmortem brain tissue. Each tsPFD is characterized by specific brain abnormalities that selectively influence the functional regions of brain networks responsible for the success of the respective motor task, according to our central hypothesis. The researchers will investigate the following two objectives in tsPFDs: identify distinct features of brain functional network abnormalities underlying task-specificity in multiple tsPFDs; determine physiological correlates of functional neuroimaging abnormalities in tsPFDs. The proposed study is significant because it is intended to establish scientific evidence that tsPFD is a network disorder with anomalies that mimic specific patterns in different tsPFDs and some abnormalities with structural-function correlations that can be related to underlying neuropathology. The researchers will be able to identify primary vs. secondary changes in tsPFDs and establish a scientific framework for the study of diagnostic biomarkers and novel therapy options for these disorders by consolidating the findings from multimodal cross-disciplinary research to a cohesive and pathophysiologically meaningful picture.

Source link: https://clinicaltrials.gov/ct2/show/NCT03042962


Brain Inflammation and Function in Alcoholism

Here's the key goals in Phase I: To determine if there is inflammation in the brain of alcoholics and if present, determine if it recovers after at least three weeks of abstinence as compared to groups. The aim of Phase II is to determine whether group differences in inflammation in the brain of AUD subjects who refrain from alcohol for at least three weeks or relapse for at least three weeks. Secondary findings are used to determine inflammation's health and safety as determined by: regional brain glucose metabolism, functional brain stimulation to cognitive tasks, computerized brain mapping, resting functional connectivity, and neuropsychological testing. Participants with alcohol use disorder were diagnosed as per DSM IV or DSM 5 AUD and healthy controls, according to the study participants. To determine brain function, functional reactivity, and functional connectivity, participants in phase I will have two positron emission tomography scans, one with [11C]PBR28 and one with 18FDG and magnetic resonance imaging scans to determine brain structure, functional reactivity, and functional connectivity. If relapsed/continued to drink alcohol after Phase I, relapsers would be eligible for Phase II, but it will be completed at least three weeks later in AUD participants who finished phase I who either abstained from alcohol or resumed/continued to drink alcohol after Phase I. In AUD participants who completed phase I, lapsed/continued to drink alcohol after Phase I.

Source link: https://clinicaltrials.gov/ct2/show/NCT02233868

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions