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Hormone Replacement Therapy - Europe PMC

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Last Updated: 11 November 2022

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Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy.

While growth hormones and insulin-like growth factors are not necessary for reproductive longevity, results show that they interact with follicle-stimulating hormone throughout ovarian folliculogenesis. We wanted to investigate the connection between IGF-1 level and clinical pregnancy rate after ovarian stimulation, with or without intrauterine insemination in women with GH deficiency treated with GH replacement therapy at birth. We design and methods We have been collecting data from 19 women with both GHD and hypogonadotropic hypogonadism who referred to our reproductive medicine service retrospectively collected data. Among the seven patients receiving GHRT after ovarian stimulation, higher IGF-1 levels were highly associated with clinical pregnancy. Conclusions This is the first report to examine the connection between IGF-1 status and clinical pregnancy risk in GH-treated women at pregnancy. Practitioners should investigate the GHD and IGF-1 factors when treating female fertility due to hypogonadotropic hypogonadism.

Source link: https://europepmc.org/article/MED/36219843


Hormone replacement therapy prescribing in menopausal women in the UK: a descriptive study.

Background information on the use of hormone replacement therapy to treat menopause-related symptoms are lacking. Aim To describe the prescribing of HRT in a group of UK menopausal women. Method outlined in the database Women with documented menopause and/or age between January 2010 and November 2021 were extracted from the database. The denominator was used annually by a woman who got their first prescription for HRT. The estimated annual prescribing prevalence per 100 women was calculated using mid-year menopausal population estimates. The percentage of women in possession of a prescription for HRT increased from 8. 89% in 2010 to 6. 86% in 2020. Conclusion This report shows that during the study period, there has been a steady rise in the number of women receiving their first prescription for HRT, which means that HRT has regained approval.

Source link: https://europepmc.org/article/MED/36216368


State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson's disease: What meta-analysis studies cannot tell us.

The menopause is a mid-life endocrinological process that has a significant effect on women's central nervous system functions. Several scientific studies have examined the effects of ovarian hormone decline on neurological disorders such as Parkinson's disease and Alzheimer's disease in recent decades.

Source link: https://europepmc.org/article/MED/36337706

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions