High Blood Pressure - Springer Nature

Perirenal adipose afferent nerves sustain pathological high blood pressure in rats

"Hypertension is a pathological symptom of persistent elevated blood pressure in which the root physiological mechanisms are uncertain. " PRAT ablation or denervation in spontaneous hypertensive rats results in a long-term decrease of high BP in spontaneous hypertensive rats, but no effect has been found on control rats. Hypertension in SHR is based on augmented interventions and analysis of L1-L2 dorsal root ganglia neurons, as well as loss-of-function and neuron transcriptomics findings. PRAT afferent nerves are a pro-hypertensive node that maintains high blood pressure by suppressing CGRP, giving us a therapeutic goal to combat primary hypertension. ".

Source link: https://doi.org/10.1038/s41467-022-30868-6

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