Advanced searches left 3/3

Hepatitis B - Wiley Online Library

Summarized by Plex Scholar
Last Updated: 11 June 2022

* If you want to update the article please login/register

The loss and return of self: An interpretative phenomenological analysis of coping and recovery from chronic hepatitis B in China

"Chronic hepatitis B is a common disease with varying negative effects. " In this research, the lived experience of coping and recovery of a patient with CHB was explored. With one participant who had been recovered from CHB for ten years, a semi-structured interview was held in accordance with one participant. The studies revealed that the disease is closely associated with moral esteem, which means that CHB diagnosis could lead to a loss of moral face among Chinese people living with the condition.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/nhs.12963


Horizontal transmission might be a common route of hepatitis B virus exposure in highly endemic areas

"The introduction of the free HBV vaccine for children in China has significantly reduced the risk of HBV infection in China, making it a unique real-world perspective on tracking the prevalence of HBV transmission patterns in China. " In four regions of North to South in Eastern China, 53 371 individuals aged 1 to 60 were found between July 2019 and April 2020, according to Crossu2010sectional results of HBV seromarkers from July 2019 to April 2020. Positive rates of HBV surface antigen and antibody against the HBV core antigen have largely increased from North to South. Despite higher positive rates of anti-u2010HBs among people aged 62 to 192 years in the South, the positive antibodies against HBsAg and anti-u2010HBc remained at low levels in the North, though they were increasing among people aged > 12 years in the South. The majority of the anti-u2010HBs adults in the South were anti-u2010HBc, up to 80%, when it was 13. 6% in the North. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jmv.27905


Epigenetic regulation of Fructose‐1,6‐Bisphosphatase 1 by host transcription factor Speckled 110 kDa during Hepatitis B Virus infection

"Hepatitis B virus is the most common cause of liver disease in liver disease, ranging from acute and chronic liver disease to liver cirrhosis, and hepatocellular carcinoma. " HBV infection has been widely reprogrammed the host cellular metabolic pathways for viral pathogenesis, according to studies. We present FBP1 upregulation on HBV infection in this research and propose a new way of epigenetic reprogramming of FBP1 by HBV using host factor Speckled 110kDa. Sp110 Bromodomain's acetylated lysine 18 of histone H3 as a specific interactor. In addition, we found that Sp110 is recruited on H3K18Ac-enriched FBP1 promoter, facilitating the recruitment of deacetylase Sirtuin 2 on that site in the presence of HBV. In addition, Sp110 can be used as a prognostic marker for the hepatitis-mediated HCC patients, where high Sp110 expression significantly reduced their survival. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1111/febs.16544


TRPM2 regulates autophagy to participate in hepatitis B virus replication

"According to the latest study, the current research sought to investigate the role of transient receptor potential cation channel subfamily M2 in HBV replication. " In addition to animal experiments to establish the role of TRPM2 regulation of HBV replication in vivo, human experiments were designed to investigate the role of p47 phox and autophagy in TRPM2 regulation of HBV replication, in vivo. TRPM2 interacted with p47 phox and positively regulated p47 phox, such that u2010 regulation and the use of Rapamycin significantly reduced the inhibitory role of silencing TRPM2. Our results show that HBV infection promotes TRPM2 expression, and TRPM2 promotes TRPM2 expression, and TRPM2 interacts with p47 phox to promote autophagy and promote HVB replication. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jvh.13710


What facilitates hepatitis B and hepatitis C testing and the role of stigma among primary care patients in China?

"Approximately 80% of primary healthcare facilities in China are able to provide hepatitis care services by 2021. " This research was designed to assess hepatitis B and C test uptake, determine the causes of testing, and determine the predictors of hepatitis stigma among primary care patients. Patients requesting medical attention in the University of Hong Kong's family medicine and primary care units conducted a cross-u2010sectional survey. U2010Shenzhen Hospital, China, 10 patients seeking medical attention. Participants were either 30 years or older and had not been screened for HBV and HCV in the previous 12 months. HCV testing was found with HBV testing; and HBV testing was also linked to family history of HBV. In conclusion, HCV testing uptake among primary care patients was poor and needs to be expanded. Integrating HCV and HCV testing procedures and boosting family and family involvement for disclosure may help to raise testing uptake. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jvh.13711


A morphometric analysis of hepatitis B subviral particles shows no correlation of filament proportion and length with clinical stage and genotype

"It was recently reported that the composition of circulating hepatitis B virus particles could be used to distinguish the various stages of chronic hepatitis B virus infection, with significantly smaller amounts of L and M proteins in active carriers than in patients with chronic hepatitis. " L protein is abundant in virions and filamentous SVPs, but it is almost absent from spherical SVPs. By doing a retrospective analysis of SVPs in these two groups of patients with chronic hepatitis infected with different HBV genotypes, we therefore did a morphometric examination of SVPs in those two populations of patients. With a digital camera, the percentage of filamentous SVPs and filament length for 100 SVPs was determined. By the Sanger method, the L protein PreS1 promoter was sequenced from viral genomes. Increased circulating filamentous SVPs are probably more closely related to individual host factors than to viral strain characteristics or disease stage, according to the study.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jvh.13712


Mortality and cause of death in persons with chronic hepatitis B virus infection versus healthy persons from the general population in Denmark

"The study sought to establish adjusted all-u2010cause mortality and cause of death in people with chronic hepatitis B virus infection in comparison to ageu2010 and sex u2010 matched people from the general population. " In Denmark, we used national registry to identify people aged u226518 years with chronic HBV disease in 2002-u2013, 2017; we also had 10 age-u2010 and sexmatched controls for each, which included both gender and sex. There were 6988 people with persistent HBV infection and 69,847 controls, as well as 69,847 controls. During a median follow-up of 7. 7 years, 315 people with u2014chronic HBV infection in 1525 died. People with chronic HBV infection, including hepatocellular carcinoma, external causes, endocrine disease, genitourinary disease, and neoplasms were all linked to liver disease, including hepatocellular carcinoma, hepatitical disease, genitourinary disease, and neoplasms. In conclusion, this analysis found an elevated allu2010cause mortality in people with persistent HBV infection in comparison with ageu2010 and sexu2010 controls with no persistent HBV infection, which remained after adjustment for several confounding factors. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jvh.13713


STAT4 genetic polymorphism significantly affected HBeAg seroconversion in HBeAg‐positive chronic hepatitis B patients receiving Peginterferon‐α therapy: A prospective cohort study in China

In a retrospective analysis of chronic hepatitis B virus infection patients, a variant in signal transducer and activator of transcription 4 was found to correlate with interferonu00b1's response. " In the GT/TT group's treatment group, we saw a larger decrease in HBV DNA load and a significant rise in the HBeAg seroconversion rate in the GG group and a higher HBeAg seroconversion rate in the GG group at week 72 than in the GG group at week 72. The HBeAg seroconversion rate in the GT/TT group in NAu2010experienced patients was higher than that in the GG group at week 72. In addition, patients in the GT/TT group had a higher hepatitis B surface antigen loss rate than in the GG group in the study. Despite nau00efve and NAu20102a's treatment with PegIFN u20102a, u20132au20102a, this retrospective cohort study confirmed that STAT4 rs7574865 gene polymorphism is associated with HBeAg seroconversion and HBsAg loss, regardless of nau2010u20102a and NAu2010 experienced HBeAg u2010u20100 u2010u00e u2010u2010u20101u2010u2010u2010u2010u20101u20102au20102a.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jmv.27880


Prophylactic effect of tenofovir on viral reactivation in immunocompromised pregnant women living with hepatitis B virus

"Abstract": "Abstract "Abstract" is the word that describes the correct prophylaxis for hepatitis B virus reactivation in gestation for immunocompromised pregnant women has yet to be established. The investigation of hepatitis B surface antigen efficacy and safety in hepatitis B surface antigen u2013positive patients and the risk of hepatitis B core antibody u2013positive patients during gestation was investigated. The HBcAbu2010positive and uninfected groups were tested for differences in confounding factors, which was used to account for confounding factors. Propensity score matching was used to account for confounding factors. In the control group, there were 6 cases of hepatitis flare and 12 cases of HBVr, while 12 were in the TDF prophylaxis group. During the pregestation period with a high safety record, the HBV level at delivery was the lowest for those who had TDF during the pregestation period with a healthy safety record. Prophylactic TDF during pregestation was recommended for HBsAg;u2010positive women, but regular monitoring was recommended for HBcAbu2010positive women. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/hep4.1994


Relationship between different hepatitis B virus infection status and gestational diabetes mellitus prevalence among pregnant women with chronic HBV infection: A retrospective study

"To investigate the differences in HBV infection status and gestational diabetes mellitus and assess potential risk factors, we conducted an observational retrospective study in pregnant women with HBV-b virus infection status to compare the differences in GDM prevalence and clinical outcomes among groups divided by HBV infection status. " The prevalence of HBV-u2010infected women with abnormal liver function was higher than those with normal liver function. The prevalence of abnormal liver disease in HBV-u2010infected pregnancies with abnormal liver function was higher than those with normal liver function. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jvh.13700

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions