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Hepatitis B - Springer Nature

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Last Updated: 11 June 2022

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Screening of hepatitis B virus DNA in the serum sample by a new sensitive electrochemical genosensor-based Pd-Al LDH substrate

"Screening for hepatitis B is one of the world's most common liver virus infections, and due to the benefits of early detection and treatment of hepatitis B disease, advanced diagnostic techniques are highly needed. " A highly sensitive voltammetric genosensor is developed for hepatitis B virus detection by depositing electrochemically Pd-Al-layered double hydroxide for a short time by chronoamperometry technique on the surface of the fluorinated tin oxide electrode, which is first reported for the first time. ".

Source link: https://doi.org/10.1007/s10008-022-05176-0


Chronic hepatitis B virus infection increases the risk of upper urinary calculi

"Background" is a blog that discusses why hepatitis B virus infection is a well-known risk factor for renal disease in individuals with elevated urinary calculi. " The results of chronic HBV infection and UUC were available for 1062 patients, including 514 who underwent UUC and 548 who did not, including 514 who did not. Overall, 4. 8 percent of total patients, 8. 0% of UUC patients, and 3. 8 percent of non-UUC patients had chronic HBV infections. Patients in UUC had a significantly higher risk of HBsAg positivity than non-UUC patients. HBsAg+ UUC patients had a much higher incidence of urinary pH > 6 and staghorn stones in HBsAg-positive UUC patients than in HBsAg-negative UUC patients. Conclusions This is the first study to show that chronic HBV infection is strongly associated with UUC, particularly in males. In UUC patients with chronic HBV infection, the urinary pH >6 and staghorn stones were more prevalent.

Source link: https://doi.org/10.1186/s12894-022-01038-z


A survey of knowledge, attitudes, barriers and support needs in providing hepatitis B care among GPs practising in Australia

"Background In Australia, only 22% of people with chronic hepatitis B are medically treated, and a national campaign is involving primary care workers in providing CHB-related services. Respondents had a keen understanding of at-risk populations and hepatitis B serology, and most believed hepatitis B testing and monitoring were part of their work. The survey revealed low knowledge, fear, and intention with respect to hepatitis B treatment: 23% were unaware that CHB therapy could be delayed in the community; 23% were worried that prescribing was part of their job; 23% understood that this was the case.

Source link: https://doi.org/10.1186/s12875-022-01754-3


Predictors of portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection in hepatitis B cirrhosis: a prospective study

"The aim of this prospective research was to determine the predictive and risk factors for TMIP in cirrhotic patients with a symptom of hepatitis B virus-mediated hepatitis B virus only. " Methods From September 2014 to March 2017, we recruited 115 patients with hepatitis B cirrhosis and PH who underwent LSD from September 2014 to March 2017. On postoperative day 7 and 26, patients developed TMIP, and 26 patients had TMIP on POD 30. Portal vein diameter 15. 05 mm, POD 7, 12 patients who did not have TMIP at POD 7 were newly diagnosed with TMIP, and POD 30, 12 patients who did not have TMIP at POD 7 were diagnosed with TMIP, with POD7. Portal vein diameter 14. 02 mm in another 14 patients in whom TMIP had been successful was 14. 02 mm. On POD 7, POD 30, respectively, and the Conclusion Portal vein diameters u2265-13 mm and u2265 15 mm were significant independent predictors of TMIP after LSD in patients with hepatitis B cirrhosis and PH on POD 7 and POD 30, respectively.

Source link: https://doi.org/10.1007/s00464-021-08730-5


Management of hepatitis B virus prophylaxis in patients treated with disease-modifying therapies for multiple sclerosis: a multicentric Italian retrospective study

"In a large cohort of MS patients receiving anti-CD20 or cladribine, we wanted to assess the MS Centers' behavior regarding HBV testing and prophylaxis. " Methods Retrospective, Multicentric Study Enquiry, Retrospective, Multicentric Study Enrolling Italian MS patients treated with rituximab, ocrelizumab, and cladribine were recruited for rituximab, ocrelizumab, and cladribine in a retrospective, multicentric study.

Source link: https://doi.org/10.1007/s00415-022-11009-x


Prevalence of Latent Tuberculosis Infection Among Persons with Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis

"Background Tuberculosis and chronic hepatitis B virus infection can be minimized by latent tuberculosis infection therapy and HBV vaccination, respectively. " Using a random-effects meta-analysis method, a pooled LTBI prevalence among adults with HBV was determined among adults with HBV. The prevalence of LTBI among adults with chronic HBV was expected to be 34. 2 percent, according to the survey. Conclusions: LTBI prevalence in adults with chronic HBV was two times higher than that among all non-born individuals. LTBI screening for HBV among people with chronic HBV may be warranted considering routine LTBI testing for LTBI among persons with chronic TB exposure and elevated risk of hepatotoxicity with TB medications among people with chronic HBV. To ensure that people at risk of both infections are screened and treated for LTBI and chronic HBV, reducing morbidity and mortality related to TB and chronic HBV may require hospital services and public health to ensure that people at risk of both infections are screened and treated for LTBI and chronic HBV. ".

Source link: https://doi.org/10.1007/s10620-021-07056-5


Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling

"However, the role and mechanism of GAS5's involvement in hepatitis B virus-related hepatocellular carcinoma remain unclear. " Here, the expression of hepatitis B virus x gene mRNA and GAS5 was assessed by qRTu2013PCR, and western blot analysis was performed to determine the protein expression levels. By methylation-specific PCR, the DNA methylation level of GAS5 was determined. Our results showed that HBx is increased in first cell lines, while GAS5 is reduced in HCC cell lines. We found that HBx inhibits HCC cell viability and invasion by inhibiting GAS5 expression. We then confirmed that HBx promotes DNA methylation of GAS5 by encouraging methyltransferase expression, thereby suppressing GAS5 expression. Overall, our findings indicated that HBx promotes HCC progression by inducing GAS5 methylation to reduce its expression. "Our findings point to new evidence establishing the possibility of GAS5 as a treatment target in HBV-related HCC. ".

Source link: https://doi.org/10.1007/s12079-021-00645-z


Electrochemical Biosensor for Sensitive Detection of Hepatitis B in Human Plasma

"The genosensor was effective in detecting genomic DNA in a linear range from 1. 176 to 4. 825 ng mLu22121, which is greater than the ten. 00 IU mlu22121 maximum limit of reference method, real-time PCR, used in point of care, was much higher than the 10. 00 IU mlu22121 maximum limit. " According to the EIS report, the genosensor resistance has increased exponentially as the concentration of the genomic DNA target rises exponentially.

Source link: https://doi.org/10.1007/s12010-022-03829-4


Development of sensitive and specific loop-mediated isothermal amplification combined with lateral flow device for the rapid detection of hepatitis B virus infection

"Abstract Hepatitis B virus is a very infectious blood-borne pathogen that causes many hepatic disorders, including liver cirrhosis and hepatocellular carcinoma. " The assay was performed on HBV standard plasma panels and donor plasma specimens. Methods The assay was performed on HBV standard plasma panels and donor plasma samples. DNA of HBV was extracted using the QiAamp DNA Blood Mini Kit, which was used to extract HBV DNA. HBV-LAMP-LFD assay revealed sensitivity to 92% of HBV positive plasma specimens, according to the HBV-LAMP-LFD assay. Conclusions from the research "The HBV-LFD is a fast, simple to use, versatile, and specific point-of-care diagnostic assay for the detection of hepatitis B virus in blood samples.

Source link: https://doi.org/10.1007/s42770-022-00690-9


DNA Methylation and Transcription of HLA-F and Serum Cytokines Relate to Chinese Medicine Syndrome Classification in Patients with Chronic Hepatitis B

"Objective: "Objective To investigate the molecular bases of Chinese medicine syndrome classification in chronic hepatitis B patients in terms of DNA methylation, transcription, and cytokines. Methods Genome-wide DNA methylation and 48 serum cytokines were found in CHB patients with various CM syndromes, including dampness and heat of Gan and gallbladder, Gan and Gallbladder, Gan and gallbladder, Gan and Gallbladder, Gan and Gallbladder, Gan and Gallbladder, Gan and Gir deficiency, and Pi deficiency, Gan and Shen deficiency, CHB patients with hidden signs, cytokines In CHB3, the inflammatory protein -1–u03b1 and MIP-1–u03b2 were higher in MIP-3B1 and MIP-1–u03b2 were higher than other groups, while leukemia inhibitory factor level was higher in CHB1 and HS than those groups, but CHB1 and HS were higher in CHB3 and HS than CHB2 and CHB3 groups, while CHB3 and CHB3 were higher than CHB1 and MIP-1u03b1 and inflammatory protein inflammatory protein inflammatory protein inflammatory protein -1u03b1u03b1 and MIP-1u03b1u03b1u03b1u03b2 were also increased in CHB3u03b1u03b3u03b3 u03b1 and vU03b3 were higher than other groups, while the &u03b3 were higher in CHB3u03b3u03b3u03b3u03b3u03b3u03b Conclusions "HLA-F demethylation in 5u2032 UTR of HLA-F may help to raise the mRNA expression and HLA-F expression in CHB's IL-12, MIP-1, and MIP-1b1 values.

Source link: https://doi.org/10.1007/s11655-021-3279-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions