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In 133 Saudi patients with acute hepatitis detected in King Khalid University Hospital, Riyadh, Viral etiology was investigated. There were 35 patients with acute hepatitis in whom no viral marker for HAV, HV, CMV, or Epstein-Barr virus had been found. The majority of the 51 patients with acute hepatitis due to HAV were children, and only 6 were adults. HAV in Saudi adults, acute hepatitis due to HAV, was a new occurrence in the Saudi population's epidemiologic pattern of HAV infection, an observation that was not seen earlier. This change was confirmed by the significant decrease in the prevalence of anti-HAV in 630 Saudi subjects investigated in 1994 compared to the study of 587 subjects in 1986. Because these groups are candidates for HAV vaccination, it is critical that high-risk Saudi groups be identified and evaluated for their anti-HAV status.
Multiple foodservice worker-related hepatitis A outbreaks in St. Louis County were uncontrolled by standard outbreak measures in the early 1990s. Ordinary vaccination policies can be enforced by local health departments, but this has seldom been carried out. The study's aim was to explore the current legislation 15 years ago, as well as demonstrate the effects from the amendment 15 years later. In St. Louis County, the policy appears to have reduced the number of hepatitis A outbreaks, as well as lowering the morbidity and economic burden. Local public health officials' recommendation in passing a mandated hepatitis A vaccination program are both important and relevant in today's environment. When faced with the potential need for mandated vaccination coverage for any vaccine preventable disease, the information and lessons learned could benefit other local health departments.
Source link: https://doi.org/10.3934/publichealth.2016.1.116
BACKGROUND: The secondary attack rate of hepatitis A virus among contacts of infections has risen to 5 percent. In those with a low risk of severe infections in the Netherlands, We evaluated routine use of HAV vaccine as an alternative to immunoglobulin in PEP. METHODS: According to national guidelines, disposable contacts of acute HAV infections in Amsterdam were invited 14 days after-exposure for baseline anti-HAV testing and PEP, or hepatitis A vaccine if healthy and at low risk. Incidence of laboratory confirmed secondary infection in susceptible individuals was assessed 4-8 weeks post-exposure. According to Poisson regression, in a vaccinated subgroup, there was a small risk of secondary infection. CONCLUSIONS: Timely administration of HAV vaccine in PEP was safe, but the secondary attack rate was low in those 40 years.
Source link: https://doi.org/10.1371/journal.pone.0078914
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