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Hepatitis A Vaccine - Astrophysics Data System

Summarized by Plex Scholar
Last Updated: 30 January 2022

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Incorporation of apolipoprotein E into HBV-HCV subviral envelope particles to improve the hepatitis vaccine strategy

We developed a vaccine based on chimeric HBV-HCV envelope healthy proteins forming subviral particles that cause reducing the effects of antibodies versus HCV in vitro. We found that apoE had the ability to communicate with both chimeric HBV-HCV proteins, and with the wild-type HBV S healthy protein. Immunization of New Zealand bunnies led to similar anti-S responses for all rabbits, whereas anti-E1/-E2 antibody titers differed according to the existence or lack of apoE. In verdict, the association of apoE with HCV envelope healthy proteins might be a great strategy for improving HCV vaccines based on viral envelope proteins.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1121856G/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions