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Hemolytic Anemia - DOAJ

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Last Updated: 04 August 2022

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Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs

Detailed information about the use of splenectomy for the treatment of immune-mediated hemolytic anemia or immuneu2010mediated thrombocytopenia in dogs is limited. Objectives: To retrospectively discuss the use of splenectomy as part of the IMHA, ITP, and concurrent IMHA and severe thrombocytopenia in dogs, with IMHA and severe thrombocytopenia. Animals Seventeen clientu2010owned dogs were identified across seven UK-based referral hospitals from 2005 to 2016 during a research period from 2005 to 2016. Treatment with splenectomy as part of the management strategy was classified as either successful or ineffective based on clinical results. Six of the seven dogs with ITP were treated with splenectomy as part of their training program, although one of them later developed suspected IMHA. splenectomy was performed in 4 dogs as part of a fruitful leadership program. As part of the control program, 1 case responded entirely to administration by splenectomy as part of the CIST group.

Source link: https://doi.org/10.1111/jvim.16469


Donath-landsteiner hemolytic anemia with erythrophagocytosis and platelet phagocytosis in peripheral smear: Rare findings

A rare form of autoimmune hemoglobinuria is Donath-Landsteiner hemolytic anemia or paroxysmal cold hemoglobinuria. Positive results in both direct Coombs test C3d and direct DL testing were prompted by the pathologists' unusual blood smear analysis, prompting the pathologists to begin investigating hemolytic anemia. This is the first report of both erythrophagocytosis and platelet phagocytosis in peripheral blood smear in PCH, to the best of our knowledge.

Source link: https://doi.org/10.4103/mjdrdypu.mjdrdypu_373_20


Prevalence of hemolytic anemia and hemoglobinopathies among the pregnant women attending a tertiary hospital in central India

Anemia in pregnancy is one of the leading causes of maternal morbidity, maternal, and fetal mortality in India. Although the prevalence of hemoglobinopathies, especially of the sickle cell disorders, is high in Madhya Pradesh, a study of pregnant women is lacking. However, the general 47. 1 percent anemia was present in pregnant women, ranging from 45 percent to 66%, with some appearing to indicate an absorption of anemia after nutritional supplements and improvements in maternal health care at antenatal check up due to access to medical health services. Much reduced hemoglobin level, red blood cells count, mean corpuscular volume, and mean corpuscular hemoglobin, among other pregnant women with sickle cell disorders have been reported in pregnant women with and without sickle cell disease disorders, as well as increased leucocytosis in sickle cell disorder cases than among the normal pregnant women.

Source link: https://doi.org/10.4081/thal.2015.4644


Development of New Drugs for Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia is a rare condition characterized by autoantibody-mediated red blood cell destruction, and treatment for it remain challenging. We'll explore the process of action, current research, and ongoing clinical trials of recent novel therapies for AIHA, including B-cell-directed therapy, phagocytosis inhibition, plasma cell-directed therapy, and complement inhibition.

Source link: https://doi.org/10.3390/pharmaceutics14051035


Infantile pyknocytosis: A rare cause of newborn hemolytic anemia two case reports

Infantile pyknocytosis is a rare symptom of neonatal hemolytic disease. Diagnosis is solely based on the finding of a higher percentage of pyknocytes in peripheral blood smear. The 17th and the 21st days of life respectively, with phototherapy and excellent results, we discuss the diagnostic procedure, surgical treatment, and the outcome of two neonates presented with unconjugated hyperbilirubinemia and major hemolysis.

Source link: https://doi.org/10.1016/j.phoj.2020.06.007


The Changing Landscape of Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia is a highly heterogeneous disease linked to autoantibodies directed against erythrocytes, with or without complement activation. Multiple target therapies are increasingly used in clinical practice or are in the research process, as shown by the following examples. Particularly relapsed/refractory cases may resemble pre-myelodysplastic or bone marrow failure syndromes, requiring a careful use of immunosuppressants and vice versa recommending bone marrow immunomodulating/stimulating agents. AIHA (autologous and allogeneic hematopoietic stem cell transplantation, which is growing in popularity. AIHAs can be primary/idiopathic/secondary to infections, autoimmune diseases, tumors, lesionant disorders, and medications, with lymphoproliferative disorders, among other things, further complicating their clinical picture and management. Regarding new drugs, the false positivity of the Coombs test after daratumab adds to the list of difficult diagnosis, as well as passenger lymphocyte syndrome following solid organ transplants. Finally, AIHA is increasingly reported following the treatment of solid cancers with immune checkpoint molecules inhibitors.

Source link: https://doi.org/10.3389/fimmu.2020.00946


Polyhydramnios as a sole ultrasonographic finding for detecting fetal hemolytic anemia caused by anti-c alloimmunization

Objective: It was reported in the prenatal course of a rare case of fetal anemia resulting from maternal anti-c alloimmunization. To determine the occurrence of fetal hemolytic anemia, the severity of fetal hemolytic anemia was found at her current pregnancy, titers of maternal antibodies and fetal middle cerebral artery peak systolic velocity were frequently monitored. Conclusion: This case highlighted the difficulties of dealing with maternal red cell alloimmunization during pregnancy and the limitations of noninvasive diagnostic techniques for determining fetal anemia, as well as the fact that obstetricians should refer to all available clinical data in order to provide appropriate perinatal care.

Source link: https://doi.org/10.1016/j.tjog.2022.04.006


Cold autoimmune hemolytic anemia: a rare association with triple-positive breast cancer

A 45-year-old Asian woman was born with fever, easy fatigability, shortness of breath, cervical and axillary lymphadenopathy, and other signs and symptoms of anemia. After all the baseline study, the patient was tested for Mono-coombs C3d levels, which were elevated, indicating the diagnosis of Cold autoimmune hemolytic anemia. So, the patient was diagnosed with Cold AIHA in connection with triple-positive breast cancer.

Source link: https://doi.org/10.1080/20009666.2019.1698262


Autoimmune hemolytic anemia in HCV/HIV coinfected patients during treatment with pegylated alpha-2a interferon plus ribavirin Anemia hemolítica auto-imune durante o tratamento da hepatite crônica com interferon peguilado alfa 2a e ribavirina, em pacientes com co-infecção HCV/HIV

Two cases of autoimmune hemolytic anemia in HIV coinfected patients are illustrated and described. And among patients with stable hemoglobin levels in the previous months, the late occurrence of this acute hemolytic anemia leads to the suggestion that hemoglobin levels be monitored throughout the therapy period.

Source link: https://doi.org/10.1590/S0037-86822007000600016


Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report

Abstract of the Introduction autoimmune hemolytic anemia in children under the age of 2 years is normally associated with a difficult course, with a mortality rate of around 10%. Case presentation We illustrate the case of an 8-month-old Caucasian girl who was suffering from a severe case of autoimmune hemolytic anemia that required continuous steroid therapy for 16 months. She recurrence of severe hemolysis and two more doses of rituximab one month after the last dose of rituximab. The patient developed an interstitial pneumonia with Acute Respiratory Distress Syndrome, which necised immediate admission to the intensive care unit where extracorporeal membrane oxygenation therapy was administered continuously for 37 days while still on steroids, although still on steroid therapy. Conclusions This study shows that combined immunosuppressive therapy may lead to a complete remission in children with refractory autoimmune anemia.

Source link: https://doi.org/10.1186/1752-1947-3-6443

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions