Hemoglobin Test - Europe PMC

Influence of Selective Extraction/Isolation of Heme/Hemoglobin with Hydrophobic Imidazolium Ionic Liquids on the Precision and Accuracy of Cotinine ELISA Test.

The suitability of hydrophobic imidazolium-based ionic liquids was determined, of which OMIM BF 4 was the most suitable for immediate extraction of hemoglobin into an ionic liquid without the use of any additional reagent at one extraction step. The transfer of hemoglobin is caused by the interaction of the iron atom in the heme group and the nitrogen atom of the ionic liquid cation, according to quantum mechanical experiments, although molecular dynamics simulations demonstrated that the non-covalent interactions between heme and solvent are more beneficial in the case of OMIM BF 4 in comparison to water.

Source link: https://europepmc.org/article/MED/36430168

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