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" Material and techniques: the study included 105 patients with CHF. Arterial hypertension in the anamnesis had 94%, coronary cardiovascular disease - 60%, type 2 diabetes mellitus - 40% of patients. Limit worths were calculated for various techniques for discovering blockage - the number of B lines according to ultrasound data > 5, NT-proBNP > 3465 pg/mL, liver density, reactance according to BIVA information \ u226423. 8. Substantial straight organizations of the NT-proBNP index with the number of B-lines according to lung ultrasound, liver thickness according to indirect elastometry and inverse with reactance were shown according to BIVA, in addition to liver density and responsive resistance. NT-proBNP degree, the variety of B-lines according to lung ultrasound, and liver thickness were dramatically higher, and the reactance worth was dramatically lower in patients with endpoints. Cox univariate regression evaluation showed independent anticipating worth for the advancing endpoint of all congestion pens evaluated by various methods such as NT-proBNP, lung ultrasound, indirect elastometry, and BIVA. Cox Multivariate Regression Analysis Confirmed Independent Predictive Significance for the Potential Endpoint Risk for the complying with - Reactance, the number of B-lines by ultrasound of the lungs, NT-proBNP. Verdict: NT-proBNP degrees, the variety of B lines by ultrasound of the lungs, liver thickness and reactive resistance according to the BIVA, executed at discharge from the healthcare facility in patients with chronic heart failure, have an independent prognostic value, while the prognostic role of assessing the reactance according to the BIVA had optimal input. ".
Source link: https://zenodo.org/record/6661275
" Methods: We re-analyse our data with propranolol and the ACE-inhibitor captopril in infants with extreme heart failure as a result of congenital heart disease as published 20 years back and the existing lasting follow up information. Results: Propranolol however not Captopril considerably reduces clinical heart failure and neurohormonal activation of the renin angiotensin aldosterone system. In comparison to matured with genetic heart disease \ u2013 preoperatively treated with digoxin and diuretics - our patients up to the age of 15 years \ u2013 preoperatively treated with propranolol without frusemide \ u2013 have normal myocardial function and heart rate variability. Conversation: The evidence-based data of propranolol to deal with severe heart failure in babies with genetic heart disease are the best we have. Final thought: Further researches are required to evidence the influence of propranolol in infants with extreme heart failure on long-term neurodevelopment, endothelial- and myocardial function. ".
Source link: https://zenodo.org/record/6623308
" 1 st group was comprised by the men with heart failure and benign prostatic hyperplasia with testosterone deficiency; 2 nd group \ u2013 by the men without testosterone shortage. The men with heart failure and benign prostatic hyperplasia with testosterone shortage had a significantly higher level of advanced glycation end items, galectin-3, matrix metalloproteinases-9 activity in contrast with men with heart failure without testosterone deficiency. Correlation relations in between serum advanced glycation end products in patients of the major group with age, ejection fraction, testosterone level were figured out \ u2013 r= 0. 48, r= -0. 62, r= -0. 66 respectively. Middle-aged men with heart failure with preserved ejection portion and benign prostatic hyperplasia with testosterone deficiency are characterised by increased product advanced glycation output, galectin-3, matrix metalloproteinases-9 activity, C-reactive protein. Serum advanced glycation output are potential biomarkers of growth of heart failure with phenotype of preserved ejection portion in this cohort. ".
Source link: https://zenodo.org/record/6595162
" Abstract: The article is dedicated to chronic heart failure in the elderly. The occurrence of the disease, risk elements, features of the scientific photo and medical diagnosis of heart failure in the elderly are highlighted. According to literature information, from 20 to 50% of senior outpatient patients do not comply with the recommendations. It is necessary to examine the aspects impacting the adherence of elderly and aged patients to pharmacotherapy. Search phrases: chronic heart failure, aging, heart disease, arterial hypertension, heart failure with preserved ejection fraction. ".
Source link: https://zenodo.org/record/6591879
" External validation of a model in a new data source does not have context, where the outside validation can be contrasted with a standard in this database. Repetitive pairwise outside validation is a framework that uses a turning model advancement and recognition strategy to contextualize the evaluation of performance across a network of data sources. As a use situation, we forecasted 1-year risk of heart failure in patients with type 2 diabetes mellitus. As a use instance, we established and validated models to anticipate 1-year risk of heart failure in patients booting up a 2nd medicinal intervention for type 2 diabetes mellitus. We leveraged the power of the Observational Medical Outcomes Partnership common data model to develop an open-source software to increase the consistency, rate, and transparency of this procedure. Results An overall of 403,187 patients from fve data sources were included in the research study. When we externally verified these models in a new database, 3 models achieved consistent efficiency and in context typically done in a similar way to models developed in the database itself. The addition of a baseline model in all designing actions provides better context to the efficiency gains of increasing model complexity. The use situation demonstrates that IPEV provides a significant opportunity in a new era of standardised information and analytics to improve insight into and count on in prediction models at unprecedented scale. ".
Source link: https://zenodo.org/record/6560744
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