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Heart Failure - PLOS

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Last Updated: 19 June 2022

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Multi-system trajectories and the incidence of heart failure in the Framingham Offspring Study

" Background: Heart failure is a multi-system disease, with non-cardiac systems playing an essential role in disease pathogenesis. Techniques: We assessed 3,412 individuals from the Framingham Heart Study Offspring cohort, free of heart failure, who went to evaluation cycle 5 and a minimum of one assessment between 1995 \ u20132008. Utilizing attributes selected by means of ahead selection, we acquired a trajectory risk rating and relevant it to heart failure risk. Results: We observed 276 heart failure events during a typical adhere to up of 10 years. Individuals with the \ u2018worst \ u2019 multi-system trajectory account had the highest possible heart failure risk. A one-unit increase in the trajectory risk rating was related to a 2. 72-fold increase in heart failure risk. Verdict: Incorporating multi-system trajectories reflective of the aging procedure may add incremental info to heart failure risk analysis when compared to using single-occasion attributes. ".

Source link: https://doi.org/10.1371/journal.pone.0268576


The discrepancies between clinical and histopathological diagnoses of cardiomyopathies in patients with stage D heart failure undergoing heart transplantation

" Background: This research aimed to establish the etiology of stage-D heart failure and the occurrence and prognosis of misdiagnosed cardiomyopathy in patients going through heart transplantation. Methods and outcomes: We retrospectively evaluated 127 successive patients from February 1994 to September 2021 admitted for heart transplant in our tertiary center. Pre-transplant clinical diagnosis was compared with post-transplant pathological medical diagnosis. The most common misdiagnosed cardiomyopathy was nonischemic cardiomyopathy accounting for 6% of all patients. Pre-transplant cardiac MRI and endomyocardial biopsy were executed in 33 and 6 patients, respectively, with both executed in 3. Throughout the 5-years follow-up period, 2 and 44 patients with and without pretransplant misdiagnosed cardiomyopathy passed away. Verdicts: The prevalence of misdiagnosed cardiomyopathy was 6% of patients with stage-D HF undertaking heart transplantation, the misdiagnosis primarily occurred in nonischemic/dilated cardiomyopathy. With advances in heart imaging, improvements in diagnostic precision of the etiology of HF can improve targeting of treatment. ".

Source link: https://doi.org/10.1371/journal.pone.0269019

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions