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HCG - ClinicalTrials.gov

Summarized by Plex Scholar
Last Updated: 16 July 2022

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Can Biotin Supplementation be Used to Mask hCG Abuse?

Due to its similarity to FSH and LH, it can be used as a female fertility treatment, but it can also stimulate testosterone production in the male testes, and it is often used as a treatment for certain cases of hypogonadism. In certain clinical trials that use biotin-streptavidin binding, excess biotin can influence immunoassay results in individuals supplementing with biotin at a dose as low as 5 mg/day. Knowing that biotin supplementation is easily available and can be widely used, it is likely that heavy biotin supplementation could mask illicit hCG use by athletes. The aim of this research is to determine whether hCG use can be mask by over-the-counter biotin supplementation, and whether Sobolevsky and Ahrens' diafiltration technique is a viable protocol for improved urine testing. In addition, we want to know how this potential masking effect is seen in serum samples verses urine tests, so biotin levels are usually lower in the serum relative to urine. The investigation will be conducted in male participants and will include two groups: hCG +oral biotin therapy and hCG + oral placebo therapy. Participants will be divided into two treatment groups, respectively: Cohort 1: hCG therapy, oral biotin supplement, and oral placebo supplement As enrollment begins, participants will be randomized equally into one of the two cohorts in 'every other' fashion.

Source link: https://clinicaltrials.gov/ct2/show/NCT05450900

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions