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Glucose Transporter Type 1 Deficiency Syndrome - Europe PMC

Summarized by Plex Scholar
Last Updated: 08 July 2022

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One Molecule for Mental Nourishment and More: Glucose Transporter Type 1-Biology and Deficiency Syndrome.

The most important transporter involved in the cellular uptake of glucose into several organs is Glucose transporter type 1, and it is highly expressed in the brain and in erythrocytes. Mutations of the SLC2A1 gene, mainly by mutations of the SLC2A1 gene, impairing passive glucose transport across the blood-brain barrier, leading to Glut1 deficiency syndrome. Complex motor disorder predominates in later-onset disorders, including dystonia, ataxia, chorea, or spasticity, which are often triggered by fasting. Using flow cytometry, there are also ongoing positive studies into erythrocytes' Glut1 surface expression. As an alternative brain fuel, ketogenic therapies still provide ketones as the primary treatment. Anaplerotic drugs can be used as alternative energy sources. Understanding the intricate interactions of Glut1 with other organs, its signaling function for brain angiogenesis and gliosis, and the intricate regulation of glucose transport, including compensatory mechanisms in various tissues, will hopefully advance therapy.

Source link: https://europepmc.org/article/MED/35740271

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions