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Germ Cell Tumor - Europe PMC

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Last Updated: 15 August 2022

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Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts.

Background and Background CNS germ cell tumors are most prevalent in pediatric and young adult patients with variable responses to surgery, radiation, and chemotherapy. Methods In 84 cases, we used a mixed transcriptomic and methylomic strategy, as well as an integrative analysis of the normal cells undergoing embryogenesis and testicular GCTs. Results Genome-wide transcriptome analysis in CNS GCTs revealed that germinoma had a transcriptomic profile typical of primitive cells during early embryogenesis with high meiosis/mitosis potentials, and that nongerminomatous GCTs had differentiated phenotypes oriented toward tissue formation and organogenesis. Co-analysis with the transcriptome of human embryonic cells revealed that germinomas had expression profiles similar to those of primordial germ cells, while embryonic stem cells' expression profiles were similar to embryonic stem cell expressions. The mutational profiles of CNS and testicular GCTs were similar; TGCTs showed increased copy number alterations, which led to enhanced copy number alterations. Based on the degree of the tumor microenvironment balance, Germinoma and seminoma were co-categorized.

Source link: https://europepmc.org/article/MED/35137206


Lymph node metastasis as the initial symptom of a germ cell tumor in an adult: A case report.

Rationale Germ cell tumors in the head and neck are extremely rare. It is unusual for lymph node metastasis to be the only and first sign of germ cell tumors in cases of germ cell tumors, but it can also lead to a misdiagnosis. The patient recovered quickly after receiving two cycles of doxorubicin and ifosfamide chemotherapy, but the number of intact lymph nodes remained unchanged after she received two cycles of doxorubicin and ifosfamide chemotherapy. Conclusions The metastasis of a germ cell tumor in adult submandibular lymph nodes should be considered a crucial differential diagnosis even though a primary tumor does not arise.

Source link: https://europepmc.org/article/MED/35905234


Successful restart of chemotherapy in a patient with primary mediastinal nonseminomatous germ cell tumor after COVID-19 infection.

Patients of acute respiratory syndrome coronavirus 2 infection in Cancer patients are thought to be extremely vulnerable. However, it is not well known when chemotherapy can be safely restored in cancer patients following coronavirus disease 2019's coronavirus disease. Here we explore the case of an 18-year-old man with primary mediastinal nonseminomatous germ cell tumor in which chemotherapy could be quickly revived after COVID-19. Chemotherapy may be revived and followed by surgery in this post-COVID-19 patient with mild illness following the discharge criteria were observed, and no symptoms had been reported.

Source link: https://europepmc.org/article/MED/35903864


Kidney Autotransplantation in the Management of Residual Retroperitoneal Mass in a Germ Cell Tumor.

The leading indication for kidney autotransplantation is ureteric disease, although it can also be used to treat renovascular diseases or neoplasms, such as complex intrasinusal kidney tumors or patients with a single kidney in patients with a single kidney. CASE PRESENTATION: We cover the case of a 26-year-old man with a nonseminomatous germ cell tumor who had undergone a left radical orchiectomy less than three months ago. The pathology of the excised specimen revealed mixed germ cell tumors, consisting of immature teratoma and yolk sac tumors, as well as clear tumor-free margins. CONCLUSIONS: This technique should be considered in a few patients as an alternative to radical nephrectomy when a retroperitoneal tumor is unresectable using standard surgical techniques or in young patients who may require nephrotoxic chemotherapy, especially in young patients with persistent kidney disease or solitary kidney disease.

Source link: https://europepmc.org/article/MED/35907696


Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex.

Background in Drosophila testes, Stem cell niche holds stem cell population identity and is essential for the homeostasis of self-renewal and differentiation. In Drosophila testes, genetic interaction analysis was used to determine the association between eIF5 and eIF2A/u03b3 genes. Conclusions Here, we found that eIF5 mediates cyst cell differentiation and the non-autonomously influenced germ cell differentiation process in CySCs. During spermatogenesis, CySCs lacking eIF5 demonstrated unbalanced cell proliferation and apoptosis, resulting in testicular germ cell tumors during spermatogenesis. Multiple metabolic pathways and several key variables that may be involved in germ cell differentiation and TGCT formation were found in a eIF5 transcriptional control network study, which highlighted multiple metabolic pathways and several key factors that could be involved in germ cell differentiation and TGCT formation. Conclusions These results revealed that CySC lineage eIF5 in Drosophila testes, together with eIF1A or eIF2b3, mediates soma-germline communications for the stem cell niche homeostasis in Drosophila testes, providing new insights on TGCT prevention.

Source link: https://europepmc.org/article/MED/35883200

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions