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Germ Cell Tumor - DOAJ

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Last Updated: 15 August 2022

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Pediatric malignant sacrococcygeal germ cell tumor with intraspinal extension

Aims: The aim of the research was to determine the appearance, prevention, and outcome of patients of sacrococcygeal malignant germ cell tumors with intraspinal extension. Materials and Methods: All cases of SC-MGCT were reviewed in order to find instances of intraspinal extension. Both were Stage 4 disease, with one suffering Altman Type 3 disease and the other having Altman Type 4 disease. Incontinence of one patient. Malignant sacrococcygeal GCTs with intraspinal extension are uncommon, and can be handled with neoadjuvant chemotherapy, which eliminates the need for extensive investigation for excision and has positive neurological and oncological prognosis.

Source link: https://doi.org/10.4103/jiaps.jiaps_101_21


Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report

Abstract Background Intracranial germ cell tumors in Western countries account for 33%u20135 percent of pediatric primary central nervous system tumors. Although they are related in embryonic origins to gonadal GCTs, which are thought to be extremely treatable with cisplatin-u2010-based chemotherapy regimens, intracranial GCTs vary in malignant potential and sensitivity to radiation and chemotherapy, with breast cancer patients generally having a poor prognosis. Case A 15-year-old boy with bifocal intracranial nongerminomatous germ cell tumors of mixed origin was discovered in a 10-year-old boy at u2010. The patient presented with an enlarged cervical lymph node and an excisional biopsy revealed pure germinoma from the primary tumors nine months after healing. The patient refused further treatment prior to scheduled focal radiotherapy, as a result of high-dose chemotherapy and autologous stem cell transplantation.

Source link: https://doi.org/10.1002/cnr2.1586


Rapidly Progressive Precocious Puberty With an Elevated Testosterone Level in a 5-Year-Old Boy With a β-Human Chorionic Gonadotropin-Secreting Intracranial Germ Cell Tumor in the Pineal Gland

The goal of peripheral precocious puberty is an infrequent etiology for early sexual growth. Intracranial germ cell tumors are unusual, but they do appear infrequently with PP, with the rate of growth influenced by the degree of tumor hormone production. Laboratory findings revealed elevated serum and cerebrospinal fluid u03b2-hCG> and 17-hydroxyprogesterone progesterone levels. Disciplinary tumors can result in peripheral PP in boys. If the tumor has elevated u03b2-hCG levels, it may lead to severe hyperactivity that results in rapid onset of secondary sexual signs. Even in those without other signs of a brain tumor, male patients with rapidly progressive PP should be considered in male patients with quickly progressing PP. Conclusion: A GCT should be considered when presenting a boy with PP if workup shows an elevated testosterone level in conjunction with an elevated u03b2-hCG level, particularly in areas of rapid growth.

Source link: https://doi.org/10.1016/j.aace.2022.04.005


Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex

Abstract Background: In Drosophila testes, the stem cell population identity remains unchanged, and is vital for the homeostasis of self-renewal and differentiation. In Drosophila testes, genetic interaction analysis was used to determine the associations between eIF5 and eIF2A/eIF3u03b3. Conclusions Here, we found that in CySCs, the translation initiation factor eIF5 mediates cyst cell differentiation and the non-autonomously affected germ cell differentiation process. During spermatogenesis, CySCs lacking eIF5 demonstrated unbalanced cell proliferation and apoptosis, resulting in testicular germ cell tumors during spermatogenesis. Multiple metabolic pathways and several key factors that may be involved in germ cell differentiation and TGCT formation were identified in a eIF5 transcriptional regulation network study, which revealed multiple physiological processes and several key factors that could be involved in germ cell differentiation and TGCT formation. Conclusions These results showed that CySC lineage eIF5 was found in the Drosophila testes, together with eIF1A or eIF2b3, mediates soma u2013germline communications for the stem cell niche homeostasis, providing new insights into the prevention of TGCTs.

Source link: https://doi.org/10.1186/s13287-022-03025-5


Mixed germ cell tumor of the pineal gland in a pediatric patient

Tumors of the pineal region are a rare medical disorder, accounting for approximately 3%-8% of pediatric tumors. Pineal parenchymal tumors and germ cell tumors are typically described as pineal parenchymal tumors and germ cell tumors, with the former being more common. A pineal gland lesion was discovered during a head MRI. This case study aims to draw attention to this elusive surgical presentation and treatment of this rarely encountered tumor, as well as stressing the importance of investigating pine gland tumors in pediatric patients with persistent, persistent headaches.

Source link: https://doi.org/10.1016/j.radcr.2022.05.024

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions