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Germ Cell Tumor - Europe PMC

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Last Updated: 15 November 2022

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Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor.

Testicular germ cell tumor is a rare disease, but it is the most common tumor among adolescent and young adult males. As exemplified by embryonal carcinoma, cisplatin-based chemotherapy is a common treatment for advanced TGCTs that are initially sensitive to cisplatino. We found that mRNA levels of the high-mobility-group nucleosome-binding gene HMGN5 and meiosis-related gene TEX11 were significantly elevated in two specific parental cell models in the corresponding parental cells. In the presence of cisplatin, we demonstrated that either HMGN5 or TEX11 knockdown significantly reduced the viability of cisplatin-resistant TGCT cells. TEX11 silencing in cisplatin-resistant TGCT cells raised the level of cleaved PARP1 protein and the percentage of double-strand break marker u03b3AX-positive cells, which was troubling. We also established the therapeutic effect of TEX11-specific siRNA on in vivo xenograft models derived from cisplatin-resistant patient-derived TGCT cells.

Source link: https://europepmc.org/article/MED/36319719


Burned-out germ cell tumor presenting with acute abdomen.

There are several etiologies that cause acute abdomen, the most common being acute appendicitis; however, there are rare causes of acute abdomen as well as ones that should be kept in mind when treating a patient with unusual clinical signs. We herein present a 26-year-old male with no previous medical or surgical experience, presenting with acute abdominal pains and distension to the ED. Pathology findings revealed the mass was caused by a burned out testis yolk sac tumor with an embryonal carcinoma component. There have been reports of just a few cases of gastrointestinal bleeding secondary to the retroperitoneal metastasis invasion. In these situations, Sampling of the retroperitoneal tumor for histopathologic diagnosis during the immediate surgical intervention facilitates diagnosis. Although scrotal examination and testis tumor marker testing is essential for optimal patient care, the possibility of a burned-out testicular tumor resulting from normal scrotal examination should always be considered.

Source link: https://europepmc.org/article/MED/36282162


A comprehensive evaluation of sexual and reproductive outcomes following robot-assisted retroperitoneal lymph node dissection for nonseminomatous germ cell tumor.

Patients can be affected by the quality of life after retroperitoneal pelvic lymph node dissection for testis tumor. 32 patients underwent RA-RPLND for stage I nonseminomatous testis cancer or postchemotherapy residual mass from January 2012 to March 2020. Following RA-RPLND, ten patients developed an andrological disorder of some sort. Hypospermia was present in 4 patients, DE in 3 patients, and ED in 3 patients. Of all these ten patients, 6 were diagnosed during the first session of our robotic therapy program. 5 of the 32 patients attempted to have a child after being diagnosed with RA-RPLND. In conclusion, a nonnegligible number of andrological conditions related to RA-RPLND, mainly due to ejaculation disorders, should be addressed, but ED incidence and overall sexual satisfaction deficit should be considered. Following RA-RPLND, there was no negative effect on fertility was reported.

Source link: https://europepmc.org/article/MED/35381697


All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant.

In the 2021 WHO Classification of Central Nervous System Tumors, Primary intracranial sarcoma DICER1-mutant is a rare and newly identified tumor group. Despite midline location, poorly defined morphology and germ cell marker expression, the association of DICER1 and NF1 hotspot mutations, as well as a unique DNA methylation signature, has lead to the diagnosis of primary intracranial sarcoma DICER1-mutant rather than germ cell tumor diagnosis.

Source link: https://europepmc.org/article/MED/36307659


Evaluation of miR-371a-3p to predict viable germ cell tumor in patients with pure seminoma receiving retroperitoneal lymph node dissection.

Introduction and objective Testicular germ cell tumor markers for testicular germ cell tumors have limited success, with particularly poor sensitivity in cases of minimal residual disease and pure seminoma. paraphrased lymph node dissection (R-371a-3p) was tested to see miR-371a-3p's effectiveness in detecting metastatic pure seminoma at retroperitoneal lymph node dissection. Methods RNA was isolated from patient serum samples obtained pre-RPLND. Five of the patients received chemotherapy before RPLND, and ten of them were chemotherapy nau00efve. Results Median's relative expression of miR-371a-3p was higher in the Seminoma group than the Benign, but the difference was not statistically significant. Nine of the ten chemotherapy patients had viable seminoma at RPLND, nine had active seminoma, and seven had elevated miR-371a-3p expression, with nine of them having elevated miR-371a-3p expression. Zero of the five postchemotherapy patients had viable GCT at RPLND, and two had elevated miR-371a-3p expression, as shown by two patients. These findings indicate that pure seminoma at RPLND is a medical context, wherein the miRNA assay may need further refinement.

Source link: https://europepmc.org/article/MED/36254623

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions