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Abstract: Testicular germ cell carcinoma is a rare disease, but it is the most common cancer among adolescent and young adult males. Patients with advanced TGCT often have a poor prognosis as a result of the acquisition of therapeutic resistance. We performed transcriptome analysis for cisplatin-resistant TGCT cells compared to parental cells to determine cisplatin resistance-related genes. The mRNA levels of the high-mobility-group nucleosome-binding gene HMGN5 and meiosis-related gene TEX11 were significantly elevated in two forms of cisplatin-resistant TGCT cell lines isolated from patient-derived TGCT cells and the NEC8 cell line, according to those in the corresponding parental cells. In the presence of cisplatin, we showed that either HMGN5 or TEX11 knockdown significantly reduced the viability of cisplatin-resistant TGCT cells. TEX11 silencing in cisplatin-resistant TGCT cells raised the level of cleaved PARP1 protein and the number of double-strand break marker u03b3AX-positive cells, increasing the number of cleaved PARP1 protein and the percentage of double-strand break marker u03b3H2AX-positive cells.
Source link: https://doi.org/10.1038/s41598-022-21856-3
Abstract Naveena A. N. Abstract Naveena A. N. Kumar Primary malignant germ cell tumor of the mediastinum is a rare condition with an incidence ranging from 1 to 2% of all childhood cancers. Although a few instances of bone metastasis from mediastinal GCTs have been reported, it has been reported that synchronous whole sternal metastasis from primary malignant mediastinal GCTs is extremely unusual.
Source link: https://doi.org/10.1055/s-0042-1757426
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