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Gastroenteritis - Crossref

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Last Updated: 11 June 2022

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First CD3/CD45RA depleted haploidentical transplant for severe combined immunodeficiency disease with Rotavirus gastroenteritis in Vietnam

"Severe combined immunodeficiency disorders include inherited disorders that lead to T cell growth, which can often be associated with serious defects in B and/or NK cells differentiation. " Rotavirus infection causes severe acute gastroenteritis and over 400,000 deaths per year in children aged 5 years, many in low and middle-income countries. RAG2 severe combined immunodeficiency has been demonstrated by genetic testing of RAG2-deficiency lacking T lymphocytes, B lymphocytes, and normal NK cells. On day +28 post 2nd transplant, there was 100% blood chimerism. After the 2nd transplant, the serum IgG level has been normalized without IVIG infusion three months later.

Source link: https://doi.org/10.52852/tcncyh.v154i6.791


Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

"Eosinophilic gastroenteritis is a subgroup of the eosinophilic gastro-intestinal disorders," is characterized by eosinophilic infiltration and chronic inflammation of the gastrointestinal tract. This paper chronicles the case of a young male patient diagnosed with EGE in 2017 based on medical and histopathologic conditions and closely monitored during five years. Biopsies also showed eosinophilic infiltration of the oesophagus, despite no reported signs of oesophageal disease. We discovered increased specific IgE to several foods and progressive blood hypereosinophilia, which predated EGE diagnosis by three years. The medical results were encouraging, but blood eosinophilia and endoscopic appearance remained almost unchanged. Since one year the patient complained of respiratory disease indicating asthma, it was imperative to continue inhaled therapy. The reported case is instructive in terms of the complicated presentation, diagnosis, and conclusion of a rare case of mucosal chronic EGE related to oesophageal involvement, peripheral eosinophilia, various food allergies, and asthma. ".

Source link: https://doi.org/10.3390/diagnostics12061381


Model-based index reveals highly varied correlation between norovirus wastewater surveillance and gastroenteritis hospital admissions

"We analyzed and modeled the long-term relationship between the wastewater surveillance findings and gastroenteritis hospital admissions in this series by monitoring the occurrence of human norovirus GII in municipal wastewater for several years. " Our results reveal that 1 the uncertainty surrounding wastewater surveillance findings can be attributed to a variety of temporal scales, and 2 investigating the pathological and environmental effects is crucial to measuring wastewater surveillance findings' reliability.

Source link: https://doi.org/10.21203/rs.3.rs-1687529/v1


Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018

"Background" is a "Background" "Acute gastroenteritis is a significant and common public health issue worldwide. In patients with acute gastroenteritis in Heilongjiang Province, China, the intention of this survey was to investigate the economic burden of disease and its determining factors. To determine the uncertainty and risk factors of acute gastroenteritis' economic burden, quantitative risk estimation and sensitivity analysis were conducted. The total economic burden of patients with acute gastroenteritis was 63,969. 22 CNY, of which the direct economic burden accounted for 63. 2 percent; the per capita economic burden was 131. 35 CNY per month. Patient with acute gastroenteritis had an average economic burden of 571. 84 CNY/person. The economic burden of self-purchased medications and the indirect economic burden of patients cannot be ignored. Further research into acute gastroenteritis' economic burden in China is needed to help determine the economic burden of acute gastroenteritis.

Source link: https://doi.org/10.3389/fpubh.2022.905458


OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis

"Background & Aims Eosinophils are the primary inflammatory effector cells that damage intestinal tissue in eosinophilic gastrointestinal diseases. " OX40 pathway activation, such as asthma, can cause allergic disorders, such as asthma, but it is not clear if OX40 is present in eosinophils to control inflammation in EGIDs. In this review, we investigated the expression and impact of OX40 on eosinophils in WT and Ox40 eosinophilic gastroenteritis mice. In intestinal and lymph tissues, eosinophils were abundantly present, and EGE mice's eosinophil production in eosinophils was on the rise, as well as considerably reduced OX40 and Type 2 cytokine production. In eosinophils, the present study revealed that Ox40 deficiency dampened the Traf2/6-related NF-u03baB signaling pathway. Conclusions OX40 can play a significant role in OVA-induced EGE by promoting eosinophil maturation and function through the Traf2/6-related NF-u03baB signaling pathway," OVA-induced EGE's progress may have lead to OVA-induced EGE's progress.

Source link: https://doi.org/10.3389/fimmu.2022.841141


Community-Acquired Rotavirus Gastroenteritis Compared with Adenovirus and Norovirus Gastroenteritis in Italian Children: A Pedianet Study

"Rotavirus is the most common pathogen in the hospital and primary care settings, followed by Adenovirus and Norovirus. " Only few studies that determine the prevalence of RV gastroenteritis have been done at the community level were published. These children's visits to the local pediatrician visit were among those aged 5 years to determine the prevalence, disease profiles, seasonal variation, and working days of adults of RV, AV, and NV gastroenteritis leading to a family's visit to a family pediatrician visit among children under the age of 5 years. Incidences of AVGEs and NVGEs were marginally higher, with similar features regarding age distribution and symptoms. In RVGEs, the risk of hospitalisation, emergency room access, and workdays lost from parents were not significantly different from those in other viral infections. RVGE's benefits in terms of hospitalization length and indirect cost are lower than those reported in previous studies. This finding supports the use of primary care networks for AGE surveillance and further research on community-acquired gastroenteritis in children.

Source link: https://doi.org/10.1155/2016/5236243


Paediatric gastroenteritis disease characteristics, management and seasonal variation in one region of Ireland: Prospective study

"Background: Acute gastroenteritis is a medical disorder and accounts for a significant global burden. " Methods: A prospective analysis of all children up to three years of age who came to Mayo University Hospital with vomiting and diarrhoea from November 18th to November 18th 2017 is the first year. The severity of gastroenteritis in children was determined using the internationally recognised Vesikari scoring system. Nosocomial gastroenteritis infections were uncommon — 129 cases were recorded; the majority of paediatric gastroenteritis cases stayed between 1-2 days; the majority of paediatric gastroenteritis cases stayed between 1-2 days. Oral Rehydration Therapy was very effective in 33 cases. The fourth week of June was the week of the year for gastroenteritis. The most number of presentations with GE was recorded in May, December and June, with the most severe GE observed in June followed by December and May in the largest number of presentations followed by December and May. Conclusion: Diarrhoea is the most common feature of gastroenteritis. "All year round viral gastroenteritis is present. ".

Source link: https://doi.org/10.24911/sjp.106-1598092241


Reduction in severity of all-cause gastroenteritis requiring hospitalisation in children vaccinated against rotavirus in Malawi

"Abstract Background Rotavirus is the primary cause of severe gastroenteritis in children aged 5 years," the author states. In Malawi, the introduction of a Rotarix virus vaccine in 2012 has reduced rotavirus-associated hospitalizations and diarrhoeal mortality. However, the effect of RV1 on gastroenteritis severity is uncertain. In Malawi, we conducted a hospital-based surveillance study to see the effect of RV1 on gastroenteritis severity in children aged 5 years old. Adjusted linear regression found correlations between RV1 vaccination and gastroenteritis severity, which were investigated. In a long-term hospital-based surveillance survey in Malawi, we found evidence of the decrease in gastroenteritis severity among hospitalized RV1-vaccinated children infected with both homotypic and heterotypic rotavirus strains as well as off-target RV1 vaccine effects against non-rotavirus diarrhoel disease.

Source link: https://doi.org/10.1101/2021.06.21.21259250


Comparison of End-Tidal Carbon Dioxide (ETCO2) Gradient and Vena Cava Collapsibility Index (VCCI) in Response to Intravenous Fluid Therapy in Patients with Moderate and Severe Dehydration and Acute Gastroenteritis

Acute gastroenteritis is one of the most common medical disorders worldwide, and dehydration in severe AGE patients can cause significant morbidity and mortality. " The respiratory rate per minute rises in dehydration dehydration, but the arterial blood carbon dioxide content is reduced, depending on the metabolic acidosis that occurs in dehydration. Given that fluid replacement and its connection with Vena Cava Collapsibility Index, this study primarily seeks to determine whether ETCO2 measurements can help detect metabolic fluid loss, dehydration level, and decline in dehydration level. According to the Primary Options of Acute Care Clinical Dehydration Scale, spontaneously breathing patients admitted to a tertiary education and research hospital with signs of AGE and were found moderately and severely dehydrated in this review. P" stands for "metric increase in ETCO2 was 3. 653 mmHg P" and the normal increase in ETCO2 was 3. 653 mmHg P" in P. ".

Source link: https://doi.org/10.1017/s1049023x22000838

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions