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Background Inherited retinal degenerations can influence daylight and night vision in different ways. Mobility thresholds from two distinct LCA genotypes are compared to dark-adapted vision measurements using the full-field stimulus test, a common desktop outcome measure of rod vision. Using logistic regression, LCA patients with the GUCY2D and CEP290 genotypes and normal subjects were analysed to determine the mobility threshold for successful navigation. Sensitivity loss estimates were based on FST related linearly to the mobility thresholds that were not correlated with visual acuity. Conclusions: With LCA's limited mobility, we can measure functional vision in severely disabled patients. Patients with LCA should have a more complete understanding of the natural history and effects of therapy in patients with LCA. Including other outcome measures of rod and cone photoreceptor-mediated vision, dark-adapted functional vision, and other outcome measures of rod and cone photoreceptor-mediated vision should lead to a more complete picture of the patient's LCA-associated treatment.
Source link: https://europepmc.org/article/MED/35701753
Background: the newly published Functional Vision Evaluation for Children Battery, which quantitatively assesses key eye and visual function for rehabilitation, was validated. Methods The design of this test consists of 12 items that demonstrate unique abilities of the functional vision in three subsequent periods. The consistency of the 3 examiners was also very high for examiner 1, examiner 2, and examiner 3.
Source link: https://europepmc.org/article/PPR/PPR501350
Whether hMT+/V5 has information about motion directions and whether the functional improvement seen in the blind is motion specific or also requires sound source location remains unsolved. To determine the effect of early blindness on the brain networks that support spatial perception in male and female humans, we used a combined functional and diffusion-weighted MRI study and individual in-ear recordings. The anterior portion of hMT + /V5 responded to moving sounds in bothsighted and blind people, according to a univariate review by the blind participants, while the posterior portion was limited to moving sounds only in blind participants. The presence of motion direction and sound position data was found in hMT +/V5 and lower in hPT in the blind group, according to a multivariate decoding study. Although both companies displayed axis-of-motion operations in hMT +/V5 and hPT, this firm was reduced in the hPT of blind people, a blind person's first group. Our findings show that the axis-of-motion system of hMT +/V5 does not depend on visual appearance, but that congenital blindness alters the response properties of occipitotemporal networks for spatial hearing in the blind. SIGNIFICANCE STATEMENT HELPING living organisms are aided by a hearing that aids them in navigating their environment. How does blindness influence the auditory network that supports auditory movement and sound source location? Our results show that the presence of motion direction and sound position information in blind and sighted people's human planum temporale was both higher and lower in hMT +/V5 and lower in human planum temporale in blind relative to sighted people, and that this functional reorganization is accompanied by microstructural changes in their links.
Source link: https://europepmc.org/article/MED/35501150
Normal dislocation of cone opsin protein has an effect on photosensitive sensitor function and central vision depressed. Crocin is a natural antioxidant that aids retinal health. In a mouse model, this review reviewed the remorative effect of crocin on residual functional vision in vivo. A retinal enhancement with brain-derived neurotrophic factor protein, contributing to the re-localization of the M opsin protein, restoration of the visual acuity, and a high spatial frequency-characterized visual contrast sensitivity function despite the fact that Crocin therapy significantly raised brain-derived neurotrophic factor protein, contributing to the re-localization of the M opsin protein, enhanced visual acuity and a high spatial frequency-characterized visual contrast sensitivity function In addition, the restorative effect of crocin on functional vision and M opsin re-localization can be reversed and blocked by a synchronous injection of a tropomyosin receptor kinase B receptor antagonist. This research investigated the important functional vision-rescuing or restoring effect of crocin in vivo by modulating M opsin location plasticity and increasing the capability of residual photoreceptor function by the BDNF-TrkB receptor pathway.
Source link: https://europepmc.org/article/MED/35565684
The key signs of retinal degenerative diseases are visual acuity and visual contrast sensitivity function. A natural product and its bioactive constituents have been shown to have health benefits, but its application in retinal tissue and functional vision protection in vivo is incomplete. We reviewed the effect of water-soluble, carotenoid-rich C. militaris extracts on the visual results of light-damaged mouse retinas in vivo using adult female CD1-0100ae albino mice in the present study.
Source link: https://europepmc.org/article/MED/35458237
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