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Functional Genomics - OSTI GOV

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Last Updated: 17 June 2022

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Functional Genomics of Serotonin Receptor 2A (HTR2A) : Interaction of Polymorphism, Methylation, Expression and Disease Association

"We used functional and structural equation modeling methods to determine the contributions of the polymorphism, DNA methylation, and clinical variables to HTR2A expression in chronic fatigue syndrome patients from a population-based survey. " HTR2A was up-regulated in CFS by allele-specific expression modulated by transcription factors at key sites in the company's promoter, including a CpG binding site at position -1,420, and Sp1 binding at CpG methylation site -1,224. On HTR2A expression, a strong negative interaction between E47 and GR binding on HTR2A expression was observed by SEM. According to this report, the promoter polymorphism can influence both transcription factor binding and promoter methylation, and promoter methylation, and both transcription factor binding and promoter methylation, as well as an individual's stress response can influence HTR2A transcription in a genotype and methylation-dependent manner. ".

Source link: https://www.osti.gov/biblio/1816640

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions