Functional Genomics - Astrophysics Data System

A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR

Here we examine the cell wall structure of a fungal pathogen Aspergillus fumigatus and four mutants depleted of key structural polysaccharides. A rigid core was found by chitin, -1,3-glucan, and -1,3-glucan, with galactosaminogistan and galactomannan present in the cell phase, according to the mobile phase, with galactogactan and galactomannan present. The distribution of -1,3-glucan in chemically isolated and dynamically distinct domains contributes to its functional diversity. We recommend a new model of cell wall architecture that may aid our knowledge of fungal pathogens' physical response to stresses.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatCo..12.6346C/abstract

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