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This research sought to investigate epidemic characteristics and spatial clusters of HFMD incidence rates in Gansu, China's southwest. Methods, Chinese Infectious Disease Information System, CDC-specific results on HFMD from 1st January to December 2018 were gathered by the China Infectious Disease Information System, including enterovirus type, acute and non-severe infections in Gansu province, China. To investigate the correlation between two types of viruses and the prevalence of HFMD, a time-series cross-correlation function and regression model was used. Dingxi City, Gansu's Dingxi City, Gansu, was identified as a hot spot for the temporal risk indices. Conclusion In Gansu, the spatial patterns of HFMD incidence were attributed to enteroviruses. The EC, according to the study, may have been a potentially early warning system for predicting severe cases of HFMD in Gansu province.
Source link: https://doi.org/10.1186/s12879-022-07393-4
We established cell lines expressing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes to investigate the common host factors associated with these IRES. We treated FMDV-IRES cells with Pycnogenol, a French maritime pine extract, first and investigated its suppressive effect on FMDV-IRES function, as PYC has been shown to have antiviral properties. We discovered that polycystic kidney disease 1-like 3 and ubiquitin-specific peptidase 31 were related to FMDV-IRES operation.
Source link: https://doi.org/10.1038/s41598-022-10437-z
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