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OBJECTIVES/GOALS: In pituitaries of post-menopausal women, an age-specific N-glycosylation occurs, resulting in a higher ratio of fully glycosylated to hypoglycosylated FSH. Pituitaries were isolated from female mice carrying an Fshb-Cre transgene on a Rosa mT/mG genetic history, and FACS treated gonadotropes with GFP-tagged gonadotropes. GFP+ cells from pituitaries of female mice aged 4m, 8m, and u00e2u2030nu00e2u00e2 u2030 12m of age were used in RNA-seq analysis and subsequent qPCR assays, as shown by RNA-Seq analysis, 8m and u00e2u00e2u00e2u00e2u00e2u00e In Pgr cKO females, age-and genotype-dependent differences in N-glycosylation enzyme expression were found, with the most significant differences observed at 13 months, when B4galt5, Man1a2, Mgat5, and Man2a1 were downregulated in Pgr cKO gonadotropes relative to controls, according to a control. Our findings reveal insights into the mechanisms at the pituitary, where an old age-specific FSH glycoform regulates osteoporosis and weight gain in post-menopausal women.
Source link: https://europepmc.org/article/MED/PMC9209246
Sertoli cells, the only form of seminiferous cell in the seminiferous tubule, regulate spermatogenesis not only by regulating their own number and function, but also by crine actions to nourish germ cells surrounded by Sertoli cells. After the follicle-stimulating hormone binds to its receptor and stimulates the follicle-stimulating hormone signaling pathway, follicle-stimulating hormone signaling pathway is enabled, Sertoli cell number will be established and improve differentiation, according to follicle-stimulating hormone signaling pathway. Spermatogonia pool care, spermatogonia differentiation, and their entry into meiosis are all positively controlled by follicle-stimulating hormone signaling. We also discuss the clinical potential of follicle-stimulating hormone therapy in male patients with infertility.
Source link: https://europepmc.org/article/MED/35780146
All cows had their corpus luteum regressed and were subjected to follicular aspiration 24 hours later, triggering the emergence of a new follicular wave on d 5 after ovulation. However, cows in replicate 2 received an intravaginal P4 unit that had not been used before. Double ovulation was 40% for control cows with no hCG and 68. 5 percent with hCG. 9. 5 u22641 11. 5 and F2 9. 5 p. 9. The hCG group had more cows with F2 > 11. 5 than those with 9. 5 u2265 F2 1. 9 and F2 9. 5 9. 5. In accordance, F2 and F3 maximum sizes were larger in the hCG group, but FSH levels were lower after F1 > 8. 5 mm compared to CONT. Regardless of hCG therapy, FSH levels were higher before deviation in cows with dual ovulations than those with single ovulations. In addition, faster F1, F2, and F3 growth rates before diameter deviation made the transition from aspiration to deviation in cows with double rather than single ovulation, and in cows treated with hCG. In conclusion, increased FSH and follicle growth before deviation seems to be a significant factor of increased incidence of double ovulation in lactating cows with low circulating P4. Also, the rise in follicle growth before deviation and in the maximum size of F2 during hCG therapy suggests that increased LH may have also played a role in triggering double ovulation.
Source link: https://europepmc.org/article/MED/35787327
The potential role of FSH and estradiol in interindividual adiposity changes in postmenopausal adoposity changes are not well documented. In all adequate measures, in unadjusted results, the subset of women who stopped HT as a result of the follow-up reported the biggest increase in FSH and decrease in E2 and gains. An rise in FSH was correlated with a rise in the percentage of total body fat, total body fat mass, and subcutaneous adipose tissue, according to a change in adjusted measurements. Conclusion Although cross-sectional results indicate that FSH is inversely related to adiposity, our longitudinal results show that elevated FSH levels were associated with greater increases in total body fat, total body fat mass, and SAT.
Source link: https://europepmc.org/article/MED/35435955
Context The majority of infertile men are diagnosed with idiopathic or unexplained infertility, as a result of a lack of etiological factors. In a group of men with idiopathic or unexplained infertility, we tried to find new genetic determinants modulating FSH levels. In association with andrological measurements, TaqMan SNV polymerase chain reaction was carried out for rs11031005 and rs10835638. A striking correlation for rs11031005/rs10835638 with FSH and FSH/luteinizing hormone ratio was apparent by validation. Conclusions: The polymorphic FSHB genomic region has been identified by the GWAS as the primary predictant of FSH levels in men with unexplained or idiopathic infertility. Given the determinant role of FSH, molecular identification of one of the identified SNVs that causes lower FSH and therewith decreases spermatogenesis may help to resolve the idiopathic/unexplained origins by this etiologic factor.
Source link: https://europepmc.org/article/MED/35305013
In addition, most recent studies examined the geometric pregnancy rates or live birth rates per transfer cycle, but not on the cumulative live birth rate per started cycle. Therefore, this report was designed to evaluate the cumulative live birth rate of rFSH-alfa and uFSH regimens for ovarian stimulation. A higher number of recovered oocytes and transferable embryos, a higher fresh embryo transfer rate, and a higher multiple birth rate among the new embryo transfer cycles were characterized by a higher number of retrieved oocytes and transferable embryos. In clinical outcomes among the frozen embryo transfer cycles, no significant difference was found. Conclusions rFSH-alfa and uFSH have similar pregnancy rates and LBR per transfer cycle, respectively, and a uFSH-alfa may have more transferrable blastocysts and elevated CLBR per cycle as opposed to uFSH.
Source link: https://europepmc.org/article/MED/35729654
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