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Abstract Purpose In postmenopausal women, new research has shown a strong correlation between follicle-stimulating hormone and non-alcoholic fatty liver disease. However, it is also unknown if FSH reduces the risk of NAFLD in men. This research was conducted to determine the connection between serum FSH levels and NAFLD in elderly Chinese men aged 80 to 1999, a particular group with poorer outcomes of NAFLD. Patients and methods In a geriatric health center, a cross-sectional analysis was done in 444 patients.
Source link: https://doi.org/10.1186/s12877-021-02490-6
The number of oocytes recovered, endometrial thickness, and uterine artery blood perfusion were not different between women who received the rhFSH vaginally or abdominally in IVF treatment; in IVF, the number of oocytes recovered, endometrial thickness, and uterine artery blood perfusion were not different between women who were either vaginally or abdominally. In addition, the serum progesterone and progesterone receptors in the local endometrium were significantly higher in the groups treated with intermittent abdominal or vaginal injections of rhFSH compared to those who received daily injection. In summary, vaginal administration of rhFSH may provide an alternative treatment regimen for women receiving IVF.
Source link: https://doi.org/10.3390/ijms221910769
In the C. elegans intestine, we show that DRL-1 and FLR-4, which have a common ancestor to mammalian mitogen-activated protein kinases, maintain lipid homeostasis. As mutations in drl-1 or flr-4 lead to stagnation, small body size, and impaired lipid homeostasis, both Flr-1 and FLR-4 function in a protein complex at the plasma membrane to promote growth. We performed a forward genetic screen for suppressors of the drl-1 mutant phenotypes and identified mutations in flr-2 and fshr-1, the orthologues of follicle stimulating hormone and its putative G protein-coupled receptor, respectively, to determine risk factors that oppose DRL-1/FLR-4. Neuronal FLR-2 does respond to growth inhibition in the absence of DRL-1/FLR-4, neuronal FLR-2 functions through intestinal FSHR-1 and Protein Kinase A. Our research uncovers a complex multi-tissue signaling network that converges on p38 signals in order to maintain homeostasis during development.
Source link: https://doi.org/10.1101/2023.01.07.523122
This research aims to determine the correlation between anti mullerian hormone and follicle stimulating hormone, as well as the detection of the above mentioned hormones in patients with primary infertility. Methodology: This is a cross-sectional correlation study in which 60 patients with primary infertility meeting inclusion criteria, attending an infertility clinic in Chalmeda Ananda Rao Institute Of Medical Sciences, Karimnagar, between October 2020 and April 2022 were recruited by simple random sampling. All patients were investigated with a transvaginal scan to determine the number of antral follicles, and a fasting venous blood sample was obtained for serum AMH and serum basal FSH levels on the third day of the spontaneous cycle. FSH basal serum FSH shows a moderately positive negative correlation with antral follicle count and a strong negative correlation with anti mullerian hormones.
Source link: https://doi.org/10.21474/ijar01/15875
In mouse follicular atresia, we investigated the role of FSH-FoxO1 pathway in this study. FSH stifled stress-induced apoptosis and the expression of FoxO1 and pro-apoptosis genes in mouse granulosa cells, according to mouse granulosa cells. Utilizing FSH signaling antagonists, the signaling cascades involved in regulating FoxO1 levels during FSH therapy were identified. Moreover, inhibition of PKA or PI3K boosted FSH-mediated AKT production, according to FSH, but inactivation of PI3K or AKT had no effect on PKA activity in the absence of FSH. During the FSH administration, cordial activation of FoxO1 also promoted MGC apoptosis. In reaction to FSH, both luciferase reporter assays and chromatin immunoprecipitation assays revealed that FoxO1 immediately linked to a FoxO-recognized element site within the FoxO1 promoter and contributed to FSH's oversight of FoxO1 expression. We propose a new model in which FSH controls FoxO1-dependent apoptosis in MGCs by coordinating the PKA2013PAPI3K2u2013FoxO1 axis and FoxO1 positive feedback.
Source link: https://doi.org/10.1038/cddis.2014.400
However, no study has found a reliable way to forecast OA recovery after LSG. The aim of this study was to determine the prognostic value of preoperative the luteinizing hormone to a follicle-stimulating hormone ratio. Venous blood was generally tested 3 days before surgery to determine the preoperative LFR. Preoperative LFR remortization is correlated with OA recovery, according to a binary logistic regression model. The receiver operating characteristic curve evulated preoperative LFRu2019s predictive capability, increasing the receiver's predictive ability. Following LSG's one-year post-operatively, preoperative sexual hormone levels, as described by LFR, could help to predict OA following LSG.
Source link: https://doi.org/10.3389/fendo.2022.1043173
Abstract The anterior pituitary manufactures six different hormones that regulate virtually all aspects of vertebrate physiology, but the underlying molecular mechanisms underlying their Ca 2+ triggered release remain unclear. A subset of the synaptotagmin family of proteins serves as Ca 2+ sensors for exocytosis in neurons and neuroendocrine cells and is thus likely to control pituitary hormone secretion. In females, Loss of syt-9's findings resulted in decreased basal and stimulated FSH secretion, only in females, resulting in changes in the oestrus cycle.
Source link: https://doi.org/10.1038/ncomms9645
Vakkuri O, Kivelu00e4 A, Leppu00e4a4 A, Leppula A. Valtonen M, Kauppila A, Kauppila A, Leppila A, Vain O, Kivelu00e4 A, Valtonen M, Leppluoto J, Leppi A, Leppila A. , Kauppila A. Pre- and postmenopausal females gained extensive changes in melatonin and follicle-stimulating hormone secretion cross-sectionally. Melatonin was found to have decreased radioimmunologically from nocturnal urine collected between 20. 00 and 08. 00 h, as well as FSH and melatonin from blood samples taken at 09. 00 h, indicating significant decline from premenopause to postmenopause. In morning serum melatonin, the trend of aging was also seen. Serum FSH levels soared sharply to highs before the age of 50, staying at a high level thereafter. Urinary melatonin was negatively associated with serum FSH. In conclusion, morphin and FSH secretion changes during the perimenopausal years, with the biggest decline in nocturnal excretion of melatonin well before menopause, suggest that melatonin can be permissibly linked to the onset of menopause.
Source link: https://doi.org/10.1530/eje.0.1350188
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