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Focal - Europe PMC

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Last Updated: 25 June 2022

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Renal tubular gen e biomarkers identification based on immune infiltrates in focal segmental glomerulosclerosis.

Objective The present study found novel renal tubular biomarkers that may have an effect on the diagnosis and treatment of focal segmental glomerulosclerosis based on immune infiltration. The batch effects were removed from the batch's R statistical software limma package and the sva package's combat function. Gene set enrichment analysis was used to interpret the gene expression results, revealing several common biological pathways. ClusterProfiler performed functional analysis of the hub genes and hub nodes involved in the submodule, using plug-in Molecular Complex Detection to screen hub modules of the PPI network in Cytoscape. To determine the immune infiltration of FSGS samples, cell-type identification by estimating relative subsets of RNA transcripts was used. In the FSGS samples, we found 179 DEGs, 79 genes with downregulated expression, and 100 genes with upregulated expression. These gene sets were highly enriched in allograft rejection signaling pathways and stimulation of immune response in biological processes, according to GSEA, who reported that these gene sets were greatly enriched in allograft rejection signaling pathways and biological responses. A key tubular renal biomarker in the diagnosis of FSGS were identified as hub genes by machine learning techniques, as well as hub nodes that were enriched in the MAPK signaling pathway. Both genetic biomarkers were found to be connected with activated mast cells, which may raise FSGS biological processes.

Source link: https://europepmc.org/article/MED/35713363


Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway.

After treatment with methanol extracts of D. tuberculatus, we were able to investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion enhancement in NHDF cells and a calvarial defect rat model. The results of the current research provide new evidence that MED may contribute to focal cell adhesion in NHDF cells and a calvarial defect rat model.

Source link: https://europepmc.org/article/MED/35615953


The Effect of Three-Dimensional Whole, Major, and Small Vasculature on Mouse Brain Strain Under Both Diffuse and Focal Brain Injury Loading.

Blood vessels are much stiffer than brain parenchyma, and their effects in finite element brain models need to be investigated. Despite the establishment of several three-dimensional brain vaping theories, no mechanical model exists for the mouse brain vasculature. We therefore created FE mouse brain models with fine 3D vasculature to investigate the effect of the vainculature on brain strains under both diffuse and focal injury loading, two common laboratory models of traumatic brain injury. Comparing maximum principal strain in mouse brain FE models with and without the vaping was investigated.

Source link: https://europepmc.org/article/MED/35079765


PNEUMATIC VITREOLYSIS VERSUS PARS PLANA VITRECTOMY IN FOCAL SYMPTOMATIC VITREOMACULAR TRACTION SYNDROME: A Randomized Trial.

In the treatment of focal symptomatic vitreomacular traction, the aim of the study is to compare pneumatic vitreolysis and pars plana vitrectomy. 15 eyes in each group were included in each group. The result was a total of 30 eyes of 30 patients with 15 eyes in each group. In 12 of 15 eyes in Group 1 and in all eyes in Group 2, traction was evidently effective, with traction in all eyes. In Group 1, the mean visual acuity increased from 0. 80 to 0. 46 logMAR, from 0. 76 to 0. 47 logMAR, according to U00b1 0. 46 logMAR, and from 0. 80 - 0. 46 logMAR to 0. 47 logMAR in Group 2, according to the obb1 0. 46 logMAR. Although 4 of the 15 eyes in Group 1 had formation of a full-thickness macular hole and 7 eyes needed resurgentry, none in the pars plana vitrectomy group had any complications requiring resurgentization. Conclusion Pars plana vitrectomy is more effective than pneumatic vitreolysis as a single intervention in the treatment of focal symptomatic VMT.

Source link: https://europepmc.org/article/MED/35723920


Cost and cost effectiveness of reactive case detection (RACD), reactive focal mass drug administration (rfMDA) and reactive focal vector control (RAVC) to reduce malaria in the low endemic setting of Namibia: an analysis alongside a 2×2 factorial design cluster randomised controlled trial.

In a low endemic environment, the goal is to determine the cost and cost effectiveness of reactive case detection, responsive focal mass drug administration, and proactive focal vector surveillance to reduce malaria. Setting The study was part of a 2nd72 factorial design cluster randomized controlled trial within 11 primary health centers in Zambezi, Namibia, within the catchment zone of 11 primary health care facilities. Participants Cost and result data were collected from the trial, which included 8948 community members who received interventions due to their residence within 500 meter of malaria index cases. Results RfMDA cost 1. 01u00d7 more than RACD, and RAVC cost 1. 7 percent more than no RAVC. The price of rfMDA+RACVC was double $ 3082 vs. S. R. A. L. D. was reduced to RACD only because it was related to RACD only.

Source link: https://europepmc.org/article/MED/35738650


Clinical and Magnetic Resonance Imaging Outcomes After Microfracture Treatment With and Without Augmentation for Focal Chondral Lesions in the Knee: A Systematic Review and Meta-analysis.

Methods In patients with focal chondral defects in the knee from 1945 to 2021, a systematic review was conducted to find studies comparing outcomes and adverse events in patients undergoing isolated MFx versus augmented MFx for focal chondral defects in the knee. Patients undergoing isolated MFx and those undergoing MFx+ augmentation found no significant differences in the mean improvement in postoperative outcomes scores compared to preoperative ones, according to the International Knee Documentation Committee, or Western Ontario and McMaster Universities' Osteoarthritis Index scores between patients undergoing isolated MFx and those undergoing MFx+ augmentation. Patients undergoing MFx + augmentation showed significant rises in the Lysholm score and postoperative MOCART ratings when compared to the uninhibited MFx group. Conclusion Patients undergoing combined MFx + augmentation reported significant improvement in mean Lysholm and MOCART scores, but not much in VAS, IKDC, or WOMAC scores when compared to patients who received isolated MFx.

Source link: https://europepmc.org/article/MED/35736251


Abdominal aortic aneurysm rupture presenting with focal weakness and altered mental status: a case report.

Background Abdominal aortic aneurysms can be symptomatic and can be discovered through routine screening or incidentally on imaging. AAA rupture is the most common reason for abdominal and/or back pain, pulsatile abdominal mass, and hypotension. Case description A 58-year-old African American man who was transported by ambulance to the emergency department via ambulance has a new psychological appearance and unilateral extremity deficit. An abdominal CT was performed, which revealed a large AAA leak with a retroperitoneal bleed. Abdominal aortic aneurysm rupture can rarely occur as a result of an acute cerebrovascular accident with altered mental status and focal neural deficits.

Source link: https://europepmc.org/article/MED/35733090


MicroRNA-155-5p Aggravates Adriamycin-Induced Focal Segmental Glomerulosclerosis through Targeting Nrf2.

Introduction Focal segmental glomerulosclerosis is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix and often associated with nephrotic range proteinuria. Methods Adriamycin nephropathy was induced by Adriamycin injection, and some mice were also injected with Anti-miR-155-5p LNA or YC-1. In Adriamycin-induced FSGS mouse models, we observed a significant rise in miR-155-5p in kidney tissue. Nrf2 was also identified as a direct target of miR-155-5p, according to further details. Supporting Nrf2 was the direct target of miR-155-5p, according to our latest findings, anti-miR-155-5p could reduce kidney oxidative stress and inflammation while also supporting Nrf2. MiR-155-5p did not increase in serum, but drastically increased in urine, so urine test results may be useful for FSGS diagnosis. Conclusion This research found a HIF-1/miR-155-5p/Nrf2 axis that can contribute to kidney injury and inflammation, which is eventually contributing to kidney injury and rapid renal fibrosis progression in FSGS.

Source link: https://europepmc.org/article/MED/35728579


Knowing What to Learn: A Metric-oriented Focal Mechanism for Image Captioning.

We explore image captioning's hard example mining and design a simple yet effective way to get the model to pay more attention to hard examples, thus improving the model's results in both general and complex situations. MFM can use image captioning to analyze examples' shortcomings and then boost the rewards of hard examples during training, differing from the existing classification schemes. We also introduced Effective CIDEr, which considers the data distribution of simple and hard examples during reward estimation in order to make MFM applicable to various datasets without tedious parameter tuning. Extensive experiments are being carried out on the MS COCO benchmark, and the results reveal that, although retaining the results on simple examples, MFM can greatly raise the quality of captions for hard examples.

Source link: https://europepmc.org/article/MED/35727782

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions