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The Lrp6 and Frizzled receptors bind to the Wnt growth factor, which results in the complex's endocytosed during canonical Wnt signaling, resulting in the complex's endocytosed. Wnt induces focal adhesion proteins' endocytosis and depletion of Integrin 1 from the cell surface, according to the results presented here. ITG1 was sequestered within membrane-bounded organelles that corresponded to Wnt-induced MVBs containing GSK3 and focal adhesion-associated proteins, according to cell culture assays. ITG1 depletion decreased Wnt signaling, according to An in vivo model based on Xenopus embryos dorsalized by Wnt8 mRNA. The cross-talk between Wnt signaling, membrane trafficking, and focal adhesions could be relevant to human cancer and cell biology. This HCC cell line has a deletion of the GSK3-binding region of the tumor suppressor Axin1 that results in constitutive activation of the Wnt pathway, as well as a stable cell line derivative that restores full length Axin1 at physiological levels.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/795994
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