Advanced searches left 3/3

Fatty Liver Disease - Crossref

Summarized by Plex Scholar
Last Updated: 13 August 2022

* If you want to update the article please login/register

Association of Severity of Non Alcoholic Fatty Liver Disease and Cardiometabolic Risk: A Cross-sectional Study

Using the diagnosis of Nonalcoholic Fatty Liver Disease (Affecting Nonalcoholic Fatty Liver Disease and determining its connection with Metabolic Syndrome and other Cardiovascular risk factors can aid in early intervention and prompt treatment. Aim: To determine if the frequency of NAFLD defined by ultrasonography is related to patient cardiometabolic characteristics. During the research period based on history and ultrasound imaging, all the 100 patients diagnosed in the hospital with NAFLD were included. To determine the severity of NAFLD and metabolic syndrome, a one-way ANOVA test was used to compare the severity of NAFLD and metabolic profile. Patients in various groups were rated according to severity of NAFLD, with statistically significant differences in Triglycerides, Total Cholesterol, HbA1c, and Alanine Transaminase. Patients with elevated CV risk can be identified by grading based on the severity of NAFLD.

Source link: https://doi.org/10.7860/ijars/2022/52414.2770


Non-invasive methods for diagnosis of non-alcoholic fatty liver disease in children and adolescents: literature review / Métodos não invasivos para diagnóstico da doença hepática gordurosa não alcoólica em crianças e adolescentes: revisão da literatura

Nonalcoholic fatty liver disease in children and adolescents, as well as knowing the connection with other medical disorders and its consequences in adult life, noninvasive diagnostic techniques may provide new avenues for diagnosis, early diagnosis, and follow-up. NAFLD in children and adolescents must be diagnosed by noninvasive methods. Conclusions: When used in conjunction with clinical findings, noninvasive markers for the diagnosis and prevention of NAFLD in children and adolescents are promising, and they may be helpful in guiding and evaluating this population for the prevention and surveillance of NAFLD.

Source link: https://doi.org/10.34117/bjdv8n4-116


Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of osteoporosis and bone fractures

Here, we sought to investigate the effect of NAFLD on the incidence of osteoporosis and fractures among osteoporosis and fractures in Germany by using the Disease Analyzer database, which contained statistics on diagnosis, prescriptions, and socioeconomics of 7. 49 million cases followed in general practices. Methods NAFLD's A total of 589 patients with NAFLD between 2000 and 2015 were matched by age, sex, index year, and three comorbidities to a cohort of equal size without NAFLD, according to the following table. Conclusions Within the time period, osteoporosis prevalence in the NAFLD group was statistically higher in the NAFLD group relative to patients without NAFLD. In a large population of patients followed in German general therapies, our results show that NAFLD is significantly associated with osteoporosis as well as bone fractures. This finding indicates that NAFLD patients may be aided by increased monitoring for bone demineralization and osteoporosis, which may lead to preventive therapeutic steps.

Source link: https://doi.org/10.1055/a-1482-9236


Mendelian randomization research investigated the association between nonalcoholic fatty liver disease and the risk of myocardial infarction

Abstract Background According to the simplest, nonalcoholic fatty liver disease and myocardial infarction are linked, according to observational studies. The relationship between NAFLD and MI is still unclear. To determine the causal correlation between NAFLD and MI, we used the two-sample Mendelian randomization technique. NAFLD and five single-nucleotide polymorphisms are strongly linked. Conclusions The comprehensive MR analysis found that there may not be a causal relationship between nonalcoholic fatty liver disease and the risk of myocardial infarction.

Source link: https://doi.org/10.21203/rs.3.rs-1912219/v1


Prevalence and Significance of Antinuclear Antibodies in Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

The relationship between antinuclear antibodies and disease risk in nonalcoholic fatty liver disease remains unclear. This research was designed to obtain reliable estimates of ANA prevalence in patients with biopsy-proven NAFLD and to determine whether liver disease risk factors were established. ANA positivity was highest among the study's biopsy-proven NAFLD patients in the presence of liver enzymes and blood lipids, the prevalence of ANA hemoglobular and portal inflammation, or the dangers of moderate-severe steatosis and significant fibrosis among the subjects with biopsy-proven NAFLD patients was 23%; however, there were no statistically significant differences between ANA-positive and ANA-negative NAFLD patients with ANA-pron ANA positivity was correlated with a significantly increased risk of significant fibrosis in the Eastern population but not in the Western population. Serum ANA was present in nearly one quarter of subjects with biopsy-proven NAFLD, but it put a greater risk of significant fibrosis in Eastern but not Western populations.

Source link: https://doi.org/10.1155/2022/8446170


Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease

However, the role of ER homeostasis as well as hepatokines in the development of non-alcoholic fatty liver disease remains to be clarified. From dataset GSE135251, we thoroughly examined liver biopsies from 206 NAFLD patients and ten controls. Six co-expression modules were found, of which the brown module stood out to be significantly related to fibrosis stage and NAFLD activity score, based on weighted gene co-expression network analysis. Subsequently, cytoscape with the cytoHubba plugin was used to find hub genes in the brown module's brown module. The top 20 hub genes were investigated by GO and KEGG enrichment analysis, which revealed the presence of extracellular matrix assembly, collagen synthesis, and decomposition, among other things. The expression of the top 20 hub genes was found to be steady rise as the fibrosis stages and NAS increased, which has been tested both in HFD fed and HFHC fed mice. In addition, COL1A1, COL3A1, COL1A1, COL3A1, PGFBP7, PGF, PTGDS, SPON1, THY1, and TIMP1 were identified as missingome genes from the top 20 hub genes. In the MCD diet-induced mice, the THY1 and collagen III levels had been shown to be significantly elevated. Hence, we gave a systemic view on ER's pathological roles and mechanisms, as well as a mystery in NAFLD progression.

Source link: https://doi.org/10.3389/fendo.2022.967016


Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial

Background: Type 2 diabetes mellitus prevalence in tandem with non-alcoholic fatty liver disease has risen over the years. Traditional Chinese medicine's multi-targeted, holistic therapy effectiveness plays a vital role in T2DM and NAFLD treatment. Using metabolomics techniques, we intend to conduct a clinical trial to determine JTTF's clinical quality, safety, and potential pathways in the treatment of T2DM and NAFLD. This report will determine the effectiveness and safety of JTTF, as well as investigating the different metabolites and potential mechanisms of JTTF treatment in T2DM mixed with NAFLD. Patients are expected to benefit from JTTF, according to We hypothesize that patients will benefit from JTTF's clinical use in the treatment of T2DM and NAFLD, leading to the possibility of further mechanistic research. This clinical trial has been approved in the China Clinical Trial Registry for this scientific trial.

Source link: https://doi.org/10.3389/fphar.2022.924021


AB1056 CHARACTERISTICS OF METABOLIC SYNDROME IN PATIENTS WITH GOUTY ARTHRITIS AND NON-ALCOHOLIC FATTY LIVER DISEASE

Historically, Gouty is a inflammatory and metabolic disorder. Non-alcoholic fatty liver disease is the most common chronic liver disease worldwide; it is closely related to obesity, type 2 diabetes mellitus, dyslipidemia, and other metabolic risk factors included in the metabolic syndrome. Goals: To determine the key traditional and disease-associated risk factors, it is necessary to determine the frequency and structure of MS in patients with gouty arthritis in combination with NAFLD. Study Design The study included 70 patients with gouty arthritis. Gouty arthritis patients in the family had a family history. Patients were divided into two groups: the first group contained 50 patients with primary gouty arthritis and signs of NAFLD, while the second group included 20 patients with gouty arthritis without signs of NAFLD. In group 1, 20 patients had arterial hypertension of the 1st degree or 30 patients of the 2nd degree. The average fasting glycecemia level was 7. 8 mmol/l, with glycosylated hemoglobin, 5. 5%, at 8. 8 u00b13. 0 mmol/l, and glycosylated hemoglobin was 7. 8 u00b11. 5%. The average HOMA index is 18. 0, with a 9. 9 mIU/l blood serum of patients of the 1st group's 6. 9 mIU/l. All measures of the metabolic syndrome in patients of the 1st group were significantly different from those in the 2nd group of patients. Conclusion Result: In patients with gouty arthritis and signs of NAFLD, a high incidence of metabolic syndrome was found. The duration of gouty arthritis was directly related to all identified causes of the metabolic syndrome.

Source link: https://doi.org/10.1136/annrheumdis-2022-eular.3435


AB0933 Development and Validation of a Nomogram for Prediction of Nonalcoholic Fatty Liver Disease in Psoriatic arthritis

The aim of this study was to develop and validate a diagnostic model nomogram for predicting the occurrence of NAFLD in patients with PsA. The independent risk factors for NAFLD were determined in the PsA patients using univariate and multivariate binary logistic regression methods and were used for the design of the nomogram prediction model. The Body Mass Index, serum triglyceride, and peripheral blood Th1 cell percentage in PsA patients is an important risk factor for NAFLD in PsA patients, according to a single nomogram prediction tool that was quickly established. Conclusions The study found that the establishment of a nomogram prediction system for PsA patients with NAFLD is particularly useful in early clinical screening and identification of such high-risk patients. C. The prediction model's calibration curve; D. The decision curve analysis of the prediction model.

Source link: https://doi.org/10.1136/annrheumdis-2022-eular.2231

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions