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Family History - Europe PMC

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Last Updated: 06 September 2022

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Is it all in the family? Sexual identity differences in DSM-5 alcohol and other drug use disorders and associations with alcohol and other drug misuse history among parents, offspring, and other relatives.

Objectives: The objective of this research was to determine the prevalence of family history of alcohol and other drug use in first- and second-degree families across sexual identity subgroups; compare AOD use among offspring of sexual minority and heterosexual parents; and investigate the correlations between FH+ and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition alcohol use disorder and other drug use disorders across sexual identity subgroups; and examine sexual identity subgroups; and the relationship between FH+ and other drug use disorder a Findings: FH+ in first- and second-degree relatives was the most prevalent among bisexual women relative to all other sexual orientation subgroups. There were no significant differences in ODUD between heterosexual FH-men and gay FH-men in the UK. Conclusions: When treating these individuals, health professionals should consider the increased likelihood of a family history of AOD abuse among sexual minorities, especially bisexual women.

Source link: https://europepmc.org/article/MED/35849748


Family history tools for primary care: A systematic review.

Background Information Many medical family history tools are available in various settings. Although FH devices are a useful health screening device in primary care, they are still underutilized. This paper investigates the FH devices that are now available on PCs and assesses their clinical results. We found 26 PC FH items on our site. Conclusion: Despite the fact that FH products can help with risk stratification of patients in PC, the clinical results of current tools are still poor, as well as integration into EMR systems. Patients are expected to be able to self-administer Twenty-one FH products.

Source link: https://europepmc.org/article/MED/35510897


Deep vicariance and frequent transoceanic dispersal shape the evolutionary history of a globally distributed fern family.

Premise The historical biogeography of ferns is usually assumed to be dominated by long-distance dispersal due to their minuscule spores. Our goals are to determine how dispersal and diversification have influenced the history of the fern family Blechnaceae, as well as their determination of differences between the northern and southern hemispheres. Methods We used sequence results from three chloroplast loci to infer a time-calibrated phylogeny for 154 out of 265 species of Blechnaceae, including representatives of all genera within the family. Blechnaceae's key findings Blechnaceae originated in Eurasia and began diversifying in the late Cretaceous. The Paleocene Thermal Maximum, a lineage of the most extant population diversified especially in the austral Pacific region. Land connections that existed near the poles during periods of warm climates likely supported migration of several lineages, according to subsequent climate-mediated vicariance, with subsequent climate-mediated vicariance shaping current distributions.

Source link: https://europepmc.org/article/MED/36063431


The evolutionary history of the relict scorpion family Iuridae of the eastern Mediterranean.

The Iuridae family is a scorpion colony with a lengthy biogeographic and taxonomic history. Generally found in Turkey and Greece, a single species is identified in northern Iraq, whereas a single species is found in northern Iraq. Sequence data from three molecular markers originating from various Iuridae taxa were analyzed within a phylogenetic framework, according to a phylogenetic framework. Both subfamilies are mainly restricted to the Anatolian peninsula and the few coastal islands; only the most derived genus Iurus has dispersed westward to Crete and Peloponnese. Three new genera of Iurinae Metaiurus, Anatoliurus, and Letoiurus are discovered based on our results. Neocalchas is one of the oldest scorpion clades in the United States, with divergence time around 27 mya.

Source link: https://europepmc.org/article/MED/36058510


The Type III polyketide synthase supergene family in plants: complex evolutionary history and functional divergence.

To name a few, primary enzymes involved in the synthesis of a variety of plant specialized metabolites, including flavonoids, stilbenes, and sporopollenin are among the key enzymes involved in the biosynthesis of a number of plant specialized metabolites, such as flavonoids, stilbenes, and sporopollenin. Although members of this supergene family have various roles, it is unclear how type III PKSs and their roles have changed. We reviewed comprehensive phylogenomics results of 60 species of the major plant lineages in each class, as well as the classification, origins, and evolutionary history of each species. Both the Pinaceae and Fabaceae lineages showed evidence for strong positive natural selection. Molecular evolutionary study of the common chalcone synthase and stilbene synthase forms revealed evidence for high positive natural selection in both the Pinaceae and Fabaceae lineages. Our results also show that the convergent evolution of enzymes involved in plant flavonoid biosynthesis is quite common. Plant species III PKSs' findings provide new insight into plant type III PKSs' origins, evolution, and functional diversity.

Source link: https://europepmc.org/article/MED/36004534


Impact of family history on clinicopathological variables and disease progression in Japanese prostate cancer patients undergoing robotic-assisted radical prostatectomy.

Objectives We investigated whether a first-degree family history of prostate cancer in Japanese patients undergoing robotic-assisted radical prostatectomy is correlated with clinicopathological variables and disease progression. A first-degree FH is defined as having a father and/or one or two brothers with PCa prior to diagnosis. Patients in the FH group were admitted at a much younger age than patients in the non-FH group. A subgroup analysis revealed significant differences in prostate-specific antigen density among the FH group and the NFH group in patients under the age of 60 years. Conclusions In this RP setting, FH of PCa was not correlated with poorer clinical signs, pathological findings, or disease progression. Patients with a FH underwent surgery at a much earlier age, and among patients over the age of 60 years, patients with a FH had significantly higher PSA density relative to those without a FH.

Source link: https://europepmc.org/article/MED/36000706


WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer.

Objects The aim of this report was to examine WNT10A variants in seven families of probands with various degrees of tooth agenesis and self-reported family history of cancer. Methods and methods We enrolled 60 young subjects from the Czech Republic with various forms of tooth agenesis. Dental phenotypes were determined using Planmeca ProMax 3D with Planmeca Romexis software, as well as oral examinations. We also analyzed the evolutionarily highly conserved WNT10A gene by capillary sequencing in the seven families after screening PAX9, MSX1, EDA, EDAR, AXIN2, and WNT10A genes on the Illumina MiSeq platform. WNT10A variant WNT10A and a recently found c. 748G > A variant of WNT10A. The most noticeable phenotype was found in a proband that was compound heterozygous for the previously identified WNT10A variant p. Phe228Ile and a newly discovered c. 748G > A variant of WNT10A. Conclusions We propose that amino acid changes in otherwise highly conserved sequences can have a significant effect on the dental phenotype.

Source link: https://europepmc.org/article/MED/35999385


Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women.

Background This review examined whether the relationship between family history of breast cancer in first-degree relatives and breast cancer risk differs depending on breast density. The Cox regression model was used to determine the relationship between family history and breast cancer risk. Results of the 4,835,547 women, 79,153, reported having a family history of breast cancer, and 77,238 women diagnosed breast cancer. Breast density did not influence the association between family history and breast cancer in both age groups, suggesting that breast density did not change the relationship between family history and breast cancer. In both three age groups, adjusting for breast density and other factors was attributed to an elevated risk of breast cancer. Breast cancer is strongly linked to breast cancer, as well as breast cancer history.

Source link: https://europepmc.org/article/MED/36049384


Family history of arterial hypertension and central adiposity: impact on blood pressure in schoolchildren.

Hypertensive schoolchildren with systolic blood pressure or diastolic blood pressure were found and described as hypertensive schoolchildren with hypertensive schoolchildren with hypertension. The relationship between waist circumference and systolic blood pressure in girls was clear, and those with a family history of arterial hypertension and a waist circumference were higher than those without a family history of arterial hypertension. Also, the connection between family history of arterial hypertension and systolic blood pressure was reduced when waist circumference was included in the study, showing waist circumference as a mediator with a 19% influence percentage. Elevation Central Adiposity remained a mediator of the link between family history of arterial hypertension and elevated blood pressure in girls, highlighting the importance of family health interventions in the prevention and treatment of arterial hypertension in children and adolescents.

Source link: https://europepmc.org/article/MED/35999624

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions