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Family History - DOAJ

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Last Updated: 06 September 2022

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Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity

Objective: To determine the relationship between overweight/obesity in schoolchildren with FTO rs9939609 polymorphism and family history of obesity. Methods: A cross-sectional research involving a population of 406 children aged 7–2013-17 years in a city in southern Brazil. Overweight/obesity in schoolchildren was determined by body mass index, and family history of obesity was self-reported by parents. Through Poisson regression, the relationship between schoolchildren's nutritional status and the presence of family obesity, stratified by polymorphism genotypes, was assessed by prevalence ratio values. Among schoolchildren with the AA genotype, 56. 4 percent had overweight/obesity; the proportion was lower for the AT and TT genotypes. Overweight/obesity in schoolchildren was attributed to a family's history of obesity, especially among children with the AA genotype. Schoolchildren have a corresponding correlation between the AA genotype of rs9939609 polymorphism and BMI. Among students with the AA genotype, the association of obesity/obesity in schoolchildren with a family history of obesity was found mainly in students with the AA genotype. Obsidade Verificar se existe es por ecuivo para relación entre o sobrepeso/obesidade de escolares de como franko de como o polimorfismo rs9939609, com o de famo de ensidade de obesidade de obesidade de obesidade o e com o e o e o e o e o e o e o e o e o e o e o e o com e o e o e o e t com o t El autorizado de massa corporal e o histu00eds, avaliado por meio dos e o histu00f3rico con obesidade por questu00f5es pelos pais o histu00edidade para o histu00edidade por questu00f3es pelos pais es por o de o de o dos o e o e de o dos e de o e o e por e o e o es o por o e pelos o es o es e es o histedo o hist o hist o A relau00e3o entre sobrepeso/obesidade do escolare do escolare foi encontrada, principally due to the fact that o cadete foi encontrada, o com o tu00f3tipo AA.

Source link: https://doi.org/10.1016/j.jped.2015.11.005


Bilateral Pheochromocytoma with Germline MAX Variant without Family History

We present a case of bilateral pheochromocytoma with a variant in the MYC-associated factor X gene. A male patient was diagnosed with adrenal pheochromocytoma and underwent left adrenalectomy at the age of 40. At the age of 43, a new tumor in the right adrenal gland was identified. Urinary metanephrine and normetanephrine levels gradually increased. The presence of a pathogenic variant in MAX was revealed by genetic testing of the peripheral blood. The number of reported cases is insufficient to determine the natural history of adrenal PCCs with the MAX version.

Source link: https://doi.org/10.3390/clinpract12030035


Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers

A family's history of pancreatic cancer is a risk factor for PC, and risk factors rise as affected families increase in number and/or develop PC at younger ages. A client with at least two PC cases in a first-degree relative is diagnosed with familial pancreatic cancer. In the narrow sense, FPC does not include some inherited cancer syndromes that are known to raise the risk of PC, such as Peutz'u2212Jeghers syndrome, hereditary pancreatitis, hereditary breast ovarian cancer syndrome, and others.

Source link: https://doi.org/10.3390/diagnostics9040169


Formative Evaluation of Clinician Experience with Integrating Family History-Based Clinical Decision Support into Clinical Practice

A leading predictor of disease risk is family history, which is a well-known predictor of disease risk. MyFamily, a family health history research tool developed to address the family health history research gap at Cleveland Clinic, Cleveland Clinic has created a family health history collection and clinical decision support system, MyFamily. com explains. To fill the family health history practice gap, Cleveland Clinic has created a family health history research system and clinical decision support software. This paper details the effects and process of implementing MyFamily into primary care, cancer survivorship, and cancer genetics clinics. Ten providers participated in semi-structured interviews that were analyzed to discover process improvement opportunities. Participants universally reported positive results on patient care, including improvements in quality, personalization of care, and patient involvement. The effects on clinical workflow varied based on practice model, with differences noted in terms of integration's ease of integration and the usage of specific report elements. This model will be used in future institutional efforts to bring clinical genomic applications into use, and it may be useful to other institutions considering the introduction of tools for personalizing medical management.

Source link: https://doi.org/10.3390/jpm4020115


Cancer Spectrum, Family History of Cancer and Overall Survival in Men with Germline BRCA1 or BRCA2 Mutations

BACKGROUND: BRCA1/2 mutations in males are not well studied relative to their female counterparts. This report explores the cancer incidences, family history of cancer, and male BRCA1/2 mutation carriers. METHODS: All men with germline BRCA1 / 2 mutations who underwent genetic testing at the Medical University of Vienna between October 1995 and October 2019 were identified. RESULTS: 45 of the 323 men included had a primary cancer diagnosis, many of whom were BRCA2 carriers, and several of whom were BRCA2 carriers. Breast cancer was the most common cancer, followed by prostate cancer. 42% of those with cancer in Vancouver were not diagnosed with any relatives. Overall, BRCA2 carriers and those with a family history of BC had a difficult time. CONCLUSION: Male BRCA2 carriers were more likely to experience cancer and had poor prognosis, according to CONCLUSION. Not all mutation carriers are able to demonstrate genetic testing, but genetic testing must be done by those who have BC or a family history of cancer to be warranted.

Source link: https://doi.org/10.3390/jpm11090917


Association of family history of cardiometabolic diseases (CMDs) and individual health behaviours: Analysis of CARRS study from South Asia

According to available research results, family history of chronic illnesses is correlated with increased risk of disease and the adoption of healthy habits. Adults without self-reported CMDs investigated the relationship between family history of cardio-metabolic diseases and healthy lifestyles among adults without self-reported CMDs. Results: After adjusting for sex, education, wealth index, city, and body mass index, family history was positively associated with non-smoking and high fruits & vegetables consumption in the age group of 45- to high physical activity in the age group of 42 to 65 years.

Source link: https://doi.org/10.1016/j.ihj.2022.05.004


Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women

Background: This report looked at whether the correlation between family history of breast cancer in first-degree relatives and breast cancer risk varies by breast cancer risk. The Cox regression model was used to determine the relationship between family history and breast cancer risk. Results: Of the 4,835,547 women, 79,153 reported having breast cancer history in family, and 78,238 women diagnosed breast cancer in their family. Breast density did not influence the association between family history and breast cancer in both age groups, with and without adjustment for breast density. In both three age groups, after adjusting for breast density and other causes, family history of breast cancer was correlated with an elevated risk of breast cancer. Conclusion: Breast cancer survivors are strongly correlated with breast cancer and breast density.

Source link: https://doi.org/10.1016/j.breast.2022.08.008


Family history of arterial hypertension and central adiposity: impact on blood pressure in schoolchildren

Abstract Background The family's history of arterial hypertension is a significant risk factor for arterial hypertension. The family's history of arterial hypertension was established and defined as hypertensive schoolchildren with systolic blood pressure or diastolic blood pressure. Conclusions It was found that 34. 7% of the students had family history of arterial hypertension, 36% of the girls, and 44. 2% of the boys had arterial hypertension. The relationship between waist circumference and systolic blood pressure in girls was clear, with those with a family history of arterial hypertension and a waist circumference greater than those with no family history of arterial hypertension. Conclusions Elevated central adoposity was a mediator of the link between family history of arterial hypertension and high blood pressure in girls, highlighting the importance of family health interventions in preventing and managing arterial hypertension in children and teens.

Source link: https://doi.org/10.1186/s12887-022-03551-4


The Relationship of Mutation Carriage of BRCA1/2 and Family History in Triple-Negative Breast Cancer: Experience from a Diagnostic Center in Turkey

Methods and Methods: The BRCA1/2 genes of 65 women diagnosed with TNBC between 2011 and 2017 were investigated using next-generation sequencing, as well as the effects of TNBC people's experience on the risk of BRCA1/2 mutation carriership rates. Patients with BRCA1/2 mutations were compared to those who did not, in terms of demographic and clinicopathological characteristics, while those who did not were not. The Ki-67 index and the number of relatives with cancer in the BRCA1/2 mutation carrier group were higher than the BRCA1/2 non-carrier group. Regardless of the type of cancer, the possibility of carrying mutations in the BRCA1/2 gene increased 1. 3 times with each increase in the number of relatives with cancer in the family's family history and the risk of inheriting mutations in the BRCA1/2 gene. TNBC's Contribution: Despite the number of relatives with cancer in the family's family tree increased 1. 3 times with each rise in the number of relatives with cancer in the family's family history and the possibility of inheriting mutations.

Source link: https://doi.org/10.4274/ejbh.galenos.2020.5909

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions