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This 11 C-Pittsburgh Compound B -PET report explores whether NL people with LOAD parents have an elevated fibrillar amyloid-beta deposition, a hallmark of Alzheimer's disease pathology, and whether there are parent-of-origin interactions. 14 NL subjects with a maternal family history of LOAD, 14 NL subjects with a paternal FH, and 14 NL subjects with no family history of any dementia were included in this study. In comparison to FH and FHm participants, AD-affected anterior and posterior cingulate cortex, prepuneus, temporal, occipital, and frontal cortices, right basal ganglia, and thalamus were found with increased PiB retention in AD-affected anterior and posterior cingulate cortex, precuneus, temporal, occipital, and thalamus, right basal PiB retention in the PCC and frontal cortex, which is intermediate between FHm and FHp subjects, was up in the FHp subjects. The increased risk of AD in AD-vulnerable areas, particularly those with affected mothers, has an elevated fibrillar A load in AD-vulnerable areas compared to controls, perhaps accounting for the apparent risk of AD.
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