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Executive functioning difficulties present in people with PTSD are one of the biggest obstacles to treatment engagement and effectiveness. Executive functions are a series of higher-level cognitive skills that organize and integrate lower-level cognitive processes in order to complete demanding, goal-directed tasks. In fact, lower EF at baseline has been correlated with poorer response to CBT in various disorders. A review of brain function during an EF task showed that impairment in EF-related brain areas, including PFC and cingulate cortex at baseline, was predicting nonresponse to CBT for PTSD. Directly targeting EF prior to CPT via cognitive training would increase executive networks and likely raise treatment effectiveness, enabling veterans to fully participate in and benefit from CPT components. In OEF/OIF veterans with PTSD, evidence shows that computerized cognitive training improves EF and performance in EF-related brain regions, increases mental health service completion rates, and increases mental health treatment completion rates, and improves mental health care service completion rates, and has psychological and functional outcomes. Objective and subjective measures of EF will be collected to see if CEFT improves EF and if this in turn mediates the connection between treatment condition and PTSD symptoms improvement. Functional neuroimaging during EF tasks will also be collected at baseline to see whether survival within an EF network predicts treatment response, as well as traditional paper-and-pencil measures of EF.
Source link: https://clinicaltrials.gov/ct2/show/NCT03260127
Positive tests for non-prescribed fentanyl increased dramatically among patients receiving other medications: by 89% for amphetamines; 48 percent for cocaine; and 39% for opiates. However, results from the U. S. Drug Enforcement Agency's drug searches show that fentanyl-related injuries, overdose, and deaths in the United States are mostly due to illicit drug shipments for its euphoric effect. Because of its greater potency, Fentanyl is more likely to cause an overdose than is heroin. Fentanyl usage in Israel has increased over the past year, and one of the treatment centers in Ilabun, "Haderech," has reported that each month over the last year, ten patients that had used fentanyl were admitted each month, on average. Currently, there are no studies that have looked at the effects of opiate use on cognitive stability and the brain. As a result of fentanyl abuse, there are no studies that have evaluated executive function, gray matter, and white matter structural shifts to the best of our knowledge. In 15 fentanyl abuse patients who will be compared to 15 healthy control participants, we propose to investigate executive function using established tasks such as the N-back task and structural brain imaging of gray matter volume and white matter tracts. Patients will be recruited after care in Israel's Israeli Ministry of Health treatment centers. Enright GP, Desmaeli-Azad B, Federico A, Enright B, Cemaeli-Azad A, Enright HA, Desmaeli-Azad B, Federico A, Enright A, Esterick S, Disney A, Enright HA, Somaeli-Azad B, Gran Feng & Sons, Wikipedia H, Maguire B, Sanfatti M, Pratoni M, San Francisco TA, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, Enright & A, Enright B, Enright ARM, Enright B, Enright A, Enright, Enright A, Enright A, Enright A, Enright A, Enright A, Enright A, En The Fentanyl Threat to Public Health is discussed in this paper. The opioid crisis in the United States is at a time of national crisis. Trends and Geographic Patterns in Drug and Synthetic Opioid Overdose Deaths in the United States, 2013-2019. Drug Testing in 2020 is expected within the COVID-19 Pandemic: Drug Testing in 2020. Crisis and Solutions by P. Skolnick P. The Opioid Epidemic Epidemic: Crisis and Solutions. A review of the opioid system in decision making and cognitive control, published on October 2, 2017: van Steenbergen, H. , Eikemo, M. , and Leknes, S. A neuroimaging meta-analysis revealed anomalies in opioid-dependent patients. Drug Alcohol Abuse, Am J Drug Abuse.
Source link: https://clinicaltrials.gov/ct2/show/NCT05469217
These students will be randomly placed in one of two arms: company-as-usual, in which children receive no additional instruction; or the reading intervention program, in which they receive 20 hours of 1:1 reading intervention over 6 weeks. Magnitude imaging and functional magnetic resonance imaging studies will be included in the study in conjunction with assessment in kindergarten, fall of 1st grade, and spring of 1st grade time points.
Source link: https://clinicaltrials.gov/ct2/show/NCT03713125
Despite the widespread interest in building inclusive societies and the promising results of executive functions' education for evaluating SES-achievement disparities, only a few studies have included schools from low-SES settings, lacking a comprehensive, evidence-based framework to support the intervention protocols. The current project, which is intended to introduce and evaluate executive skills in preschool and elementary school-aged children from impoverished settings, ultimately preventing school dropout and reducing academic inequalities.
Source link: https://clinicaltrials.gov/ct2/show/NCT05472194
Mild Cognitive Impairment (Middle) The purpose of this report is to investigate the use of tablet-based video games as a means of improving executive functions in senior adults with Mild Cognitive Impairment. The use of cognitive therapy as a means of improving general intelligence in older adults is supported by substantial evidence. This research will be conducted as a single blinded randomized control trial with a single repeatable variable and one between-subject variable. For a week period of 8 weeks, forty-two older adults with Mild Cognitive Impairment, as well as their study partner, will be randomly chosen to play either a role-playing game or a series of word or image puzzles. Participants will be assessed pre and post training with the Cambridge Brain Sciences online battery of 12 cognitive skills.
Source link: https://clinicaltrials.gov/ct2/show/NCT05468424
Executive function in late life depression is common in late life depression and is attributed to antidepressants, poor quality of life, significant disability, and elevated suicide risk. This report uses intermittent Theta Burst Stimulation, a novel type of Transcranial Magnetic Stimulation. Within the Cognitive Control Network, it also investigates the effects of iTBS on brain connectivity. With the National Institutes of Health Toolbox executive domain battery, executive function at baseline and end of study is assessed. Subjects underwent functional Magnetic Resonance Imaging (FMRI) testing the effects of iTBS on the brain's functional connectivity before and after the study's completion to determine the effects of iTBS on the brain's functional connectivity. This report will include insightful information about the effects of iTBS on mood and executive function in older adults as well as brain function research.
Source link: https://clinicaltrials.gov/ct2/show/NCT03745768
According to the data, over half of Spanish children do not follow the WHO's PA recommendations and are therefore at a greater risk of both short-term and long-term health risks. This is an alarming social and public health issue in Spain and Europe, and efficient solutions are needed. As a result of this cluster controlled trial, it will be determined if a long-term movement integration intervention in academic lessons in primary education will increase the physical fitness levels of children and reduce sedentary behaviour at school time. Movement integration is defined as infusing physical fitness, at any level of intensity, in general education classrooms during school hours. For all students in the intervention schools, MovIn-Lessons' intervention will consist of infusing physical participation in math, English, and natural sciences lessons. Participants include children who are enrolled in primary education programs studying the 6th grade. The schools will be the clusters, and the layout will be limited due to the cluster-randomized controlled trial method. And if schools are assigned to the same arm, each cluster that participates must come from different towns or cities. This process will take place: all Catalan schools in Barcelona and Girona will be invited to enroll in the study. Schools that are interested in participating in the competition and meet the inclusion criteria will be eligible to enroll. Schools will be randomly assigned to an intervention or control group with matching.
Source link: https://clinicaltrials.gov/ct2/show/NCT05468216
Around 55 million people are currently and forecast to reach 78 million by 2030 and 139 million by 2050, with Alzheimer's disease accounting for 60 percent of dementia cases. Testing the effectiveness of CS by recruiting a representative sample from many Portuguese districts and using a CS program with extensive and comprehendible content may lead to timely research into non-pharmacological therapies, contribute to the creation of social care and inclusion, promote recurrent therapeutic interventions in Portuguese institutions with dementia services, and enhance research on non-pharmacological therapies. In order to determine the effects of the individual CS on global cognitive function and specific cognitive domains in older adults with mild or moderate AD, this multicentre, randomised controlled study is thus essential.
Source link: https://clinicaltrials.gov/ct2/show/NCT05433493
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