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Estrogen - U.S. Department of Veterans Affairs

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Last Updated: 13 August 2022

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Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.

The matrix metalloproteinase 13 gene in mesenchymal cells from mice lacking the estrogen receptor alpha is the highest up-regulated gene, according to the researchers. In sham-operated female mice with conditional Mmp13 deletion in Prrx1-expressing cells, the femur and tibia lengths were shorter than in control littermates. Similarly, the femur and tibia were larger, and the osteoclast number at the endocortical surfaces was unchanged, whereas bone formation was unaffected.

Source link: https://doi.org/10.1038/s41598-022-14470-w


Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes.

We investigate the safety of pancreatic islet protection with the use of a glucagon-like peptide-1 and estrogen dual agonist. Following GLP-1 receptor antagonism, GLP1-E2-E2 does not shield mice from MLD-diabetes in estrogen receptor-deficient mice and fails to prevent diabetes in Akita mice, demonstrating the importance of GLP-1R and ER-3b1 for GLP1-E2 antidiabetic steps. In vitro, GLP-1-E2 promotes GLP-1 and E2 antiapoptotic signals in cultured islets, but in vivo, additional GLP1-E2 activation in non-islet cells expressing GLP-1R are important in preventing diabetes.

Source link: https://doi.org/10.1016/j.xcrm.2022.100598


Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease.

Not only did some cellular functions arise solely from membrane-localized steroid receptor responses, but also that rapid sex steroid signaling from membrane-localized SRs is a prerequisite for the phosphorylation, nuclear import, and titentiation of nuclear SR counterparts' transcriptional activity. This membrane-nuclear SR collaboration in physiology and disease is important to both research and analysis on the current state of knowledge of membrane-initiated estrogen, androgen and progesterone receptor signaling, membrane-associated SR potentiation of their nuclear SR homologues, and the importance of this membrane-nuclear SR collaboration in physiology and disease.

Source link: https://doi.org/10.1210/endrev/bnab041

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions