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Purpose : Identifying the lymphatic drainage pathway is critical for accurate lymph node dissection in esophageal cancer. This report was intended to assess lymphatic drainage mapping in thoracic EC using near-infrared fluorescent imaging with indocyanine green to determine its suitability for intraoperative LN drainage visualization and dissection. By endoscopy, Methods From November 2019 to August 2020, esophagectomy was performed by intraoperative NIRF navigation with ICG injected into the esophageal submucosa. Regional LNs were found in all 84 eligible patients with thoracic EC, including R, B. C. No. 5 out of a hundred five LN stations of NIRF+ probability in the upper thoracic EC were No. Conclusions Regional LN mapping of thoracic EC was carried out using ICG/NIRF imaging, which revealed several preferred LN drainage stations in various anatomical locations of the thoracic esophagus. Clinical trial registration NCT04173676 The clinical trial registration number is NCT04173676.
Source link: https://doi.org/10.1007/s00464-021-08720-7
Historical Mediastinoscopy was originally intended for lymph node biopsy and mediastinal tumor resection. The effectiveness and safety of spreadable video-assisted mediastinoscopic surgical as well as laparoscopic transhiatal esophagectomy with video-assisted thoracoscopic esophagectomy were compared in this prospective trial. Methods The study was divided into either VAME or VATE groups randomly selected groups of 200 eligible patients with esophageal squamous cell carcinoma. Both groups were compared in terms of early postoperative results and lymph node dissection. Results in the VAME were significantly shorter, the number of dissected lymph nodes was less, and intraoperative blood loss was also drastically reduced in comparison to the VATE group, respectively. In comparison to the VATE group, the incidence of pneumonia was lower and the length of hospital stay was shorter in the VAME group than in the VATE group. The chyle leak incidence seemed to be lower in the VAME group, but no statistical significance was reached, but not reached.
Source link: https://doi.org/10.1007/s00464-021-08754-x
b esophageal cancer surgery is considered the gold standard for esophageal cancer surgery due to its ability over open esophagectomy in terms of short-term outcomes. Using results from the Japan Clinical Oncology Group Study, a prospective multicenter trial comparing esophagectomy with chemoradiotherapy, this research sought to determine whether the prognosis for patients with T1bN0M0 esophageal cancer after TE is not inferior to OE. Methods Patients in JCOG0502 were compared to determine overall survival and relapse-free survival after OE versus TE after OE versus TE. In the univariable and multivariable analyses, respectively, the hazard ratio for OS was 1. 53 and 1. 10. RFS after TE, 85. 3% after OE and 79. 1% after TE. In the univariable and multivariable analyses, respectively, the hazard ratio for RFS was 1. 39 and 0. 88. Conclusion T1bN0M0 esophageal cancer patients after TE was not inferior to OE.
Source link: https://doi.org/10.1007/s00464-021-08768-5
Background Minimally invasive esophagectomy for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; on the other hand, the connection between sarcopenia and the survival of esophageal cancer patients remains uncertain. Methods Based on the Asian Working Group for Sarcopenia, we retrospectively examined 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were surgically diagnosed with or without sarcopenia. The five-year overall survival rates of the original and non-Actual sarcopenic groups were 29. 9% and 58. 9%, respectively, and the non-actual sarcopenic group's 5-year disease-free survival rate was 51. 9 percent and 58. 8%. Conclusions have been drawn in patients receiving MIE, preoperative assessment of Cr Alb may be a prognostic stratification indicator for patients with sarcopenia.
Source link: https://doi.org/10.1245/s10434-022-11337-2
Ghrelin has been shown to reduce postoperative weight loss by increasing appetite and food intake in patients undergoing upper gastrointestinal surgery. Objective We wanted to see if growth hormone induction, another common ghrelin function, may attenuate skeletal muscle loss in patients during postoperative starvation. The risk of weight loss on postoperative day 7 relative to that before surgery was much lower in the HD group than in the placebo group. On POD 7 in the HD and LD groups, muscle loss in the erector spinae muscle was significantly lower than that in the placebo group. On PODs 1, 3, and 7, and insulin-like growth factor 1 on PODs 3, 7, and 14, the incidences of growth hormones on PODs 1, 3, and 7 were significantly higher in patients who received ghrelin. Conclusion During postoperative starvation, a continuing ghrelin therapy could attenuate skeletal muscle loss in esophageal cancer patients during postoperative starvation.
Source link: https://doi.org/10.1245/s10434-022-11436-0
Methods We retrospectively identified 103 patients with thoracic esophageal carcinoma who underwent esophagectomy at our hospital between May 2018 and November 2020. Generally, the LNM in thoracic EC may be modified in the decreasing order of station 7 > station 106recR> station 2 > station 106recL. Along bilateral recurrent laryngeal nerve, the middle and lower thoracic segment also had a high incidence of LNM in the middle and lower thoracic segment, as well as bilateral recurrent laryngeal nerve. Patients with disease prevalence in less than 5% were shown on both stations, 106tbL and 111, with the lowest incidence of metastasis on average of less than 5%; only the patients with clinically positive LNs must dissect. Independent risk factors for LNM and neoadjuvant therapy did not influence the distribution of LNM in thoracic EC cases, according to the cT3-4, cN+, or G3 cases. Conclusions This research correctly identified LNM for thoracic EC patients. In thoracic EC patients, Neoadjuvant therapy did not improve overall distribution of LNM.
Source link: https://doi.org/10.1245/s10434-022-11867-9
Background Cervical esophageal cancer has a poor prognosis, but optimal treatment for CEC remains to be found, owing to its low incidence. Patients and methods We asked specialist training facilities licensed by the Japanese Broncho-Esophageal Society to report CEC cases that received curative treatment from January 2009 to December 2014, and we conducted a retrospective analysis of 302 patients identified from 27 hospitals. There were no significant differences in the 5-year overall survival rates among the patient groups who received surgery, IC, or CRT as the initial treatment; early stage and recurrent nerve injury were categorized as independent poor prognostic factors. The functional laryngeal preservation rate at the end of the observation period was 34 percent among the patients who had received IC or CRT as laryngeal-preserving surgery at the time of the initial diagnosis.
Source link: https://doi.org/10.1007/s10388-022-00921-w
This paper sought to investigate the link between PM_2. 5 concentration and hospitalization rate of esophageal cancer in Fujian province, as well as the exact lag effect between PM_2. 5 and hospitalization rate in 70 counties from the linear and nonlinear perspectives. In 70 counties of Fujian province, the hospitalization rate of esophageal cancer in the hospitalization rate revealed spatial aggregation. The study found that the spatial distribution of the esophageal cancer epidemic in 2016 was not similar to that of the PM_2. 5 average in the same year. Our findings showed that there was a 13-year lag time of air pollutant PM_2. 5 on the esophageal cancer hospitalization rate, which could provide valuable information in the early screening process of esophageal cancer screening in Fujian.
Source link: https://doi.org/10.1007/s11356-022-20587-2
Esophageal cancer is often thought of as a lethal tumor, but it is often diagnosed at a later stage. Despite the increase in the development of diagnostic and therapeutic techniques to treat EC, the poor prognosis of EC remains. Continuous evidence points to the involvement of the esophageal microbiome, inflammation, and cell structures in tumorigenesis, in addition to the role of the tumor microenvironment and its biologic and cellular components in tumor formation.
Source link: https://doi.org/10.1007/s10555-022-10026-6
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