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Esophageal Cancer - PubAg

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Last Updated: 15 October 2021

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PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy

Esophageal squamous cell carcinoma make up even more than 85% situations of esophageal cancer around the world and the 5-year survival rate related to metastatic eSCC is inadequate. The circadian clock orchestrates a number of physiological processes with the facility and synchronization of body clocks. Since cancer cells need to sustain fast proliferation and boosted metabolic demands, the escape from body clock matters in tumorigenesis. Clock related genetics may be worldwide quelched in human eSCC samples, PER2 expression still oscillates in some human eSCC cell lines. In the existing study, we verify that PER2 oscillations still take place in human cancer cells in vitro despite a deregulated circadian clock genetics expression. Profiling of eSCC cells by RNAseq exposes that when PER2 expression is low, several transcripts connected to apoptosis are upregulated. Continually, treating eSCC cells with cisplatin when PER2 expression is reduced improves DNA damage and results in a greater apoptosis rate.

Source link: https://pubag.nal.usda.gov/catalog/7350822


Impact on Short-Term Complications of Early Oral Feeding in Patients with Esophageal Cancer After Esophagectomy

To evaluate early oral feeding in temporary end results of patients with esophageal cancer after esophagectomy. 87 patients with EOF without nasogastric tube or nasogastric tube was removed within 24 h, were picked as the experimental team, whereas 92 patients that received nasojejunal tube feeding were established as the control group. EOF may not be a danger aspect for increasing the incidence of serious pneumonia and anastomotic leakage in patients with esophageal cancer after esophagectomy, and it might lower the a hospital stay period in addition to control medical costs.

Source link: https://pubag.nal.usda.gov/catalog/7303275


Cold atmospheric plasma induced genotoxicity and cytotoxicity in esophageal cancer cells

In this paper, we studied the useful results of cold climatic plasma on the esophageal cancer cell line by indirect and direct treatment and fibroblast cell lines as regular cells. Cell viability results showed that straight CAP treatment has a markedly cytotoxic impact on the decrease of KYSE-30 cells at 60 s, while indirect exposure was less impactful. Ultimately, the genotoxicity research of the direct CAP treatment showed a longer tail-DNA length and created increase in DNA damages in the cells. Treatment with direct CAP revealed genotoxicity in cancer cells.

Source link: https://pubag.nal.usda.gov/catalog/7298233


The emerging role of long noncoding RNAs in esophageal carcinoma: from underlying mechanisms to clinical implications

Gathering data have just recently shown connections between lncRNAs and esophageal cancer. LncRNAs have the potential to be made use of as prognostic and diagnostic signs separately or in combination with other clinical variables. Beyond these, although the moment is not yet ripe, therapeutically targeting EC-related lncRNAs via genetics editing and enhancing, antisense oligonucleotides, RNA disturbance, and small molecules is most likely among one of the most appealing restorative methods for the next generation of cancer treatment. We further discuss current obstacles and future creating opportunities of taking advantage of on lncRNAs for EC early diagnosis and treatment.

Source link: https://pubag.nal.usda.gov/catalog/7337725


Effect of Preoperative Nutritional Risk Screening and Enteral Nutrition Support in Accelerated Recovery after Resection for Esophageal Cancer

Many studies have revealed that preoperative dietary support can reduce postoperative complications, however there are few studies contrasting preoperative enteral nutrition with intravenous nutrition. The aim of the study was to compare the results of both dietary assistance path in esophageal cancer patients going through surgical procedure. We used the dietary threat testing 2002 for preoperative nutritional risk screening in patients with esophageal cancer treated at our department in between April 2016 and March 2019. An overall of 56 patients with an NRS2002 rating ≥ 3 and with noticeable trouble swallowing obtained preoperative parenteral nutrition or enteral nutrition. The times of first passing gas and digestive tract activity were much shorter in the EN group compared to PN team. For esophageal cancer patients with an NRS2002 rating ≥ 3 and evident trouble ingesting, preoperative EN with a stomach tube is very easy and secure to perform.

Source link: https://pubag.nal.usda.gov/catalog/7303266


Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer

Currently, numerous studies have discovered a substantial distinction in fecal plants in between normal individuals and patients with stomach cancer. Although medical study on the feedback mechanism of gastric flora and intestine microbiota is lacking, making clear the relationship in between gut microbiota and the qualities of cancer is substantial for the early diagnosis of gastric cancer. This research was conducted to assess the results of numerous studies in the past 5 years and assess the intestinal tract bacteria in patients with gastric cancer and compare them with those in patients with esophageal and tiny intestinal tract cancers cells. It was discovered that the gut microbiota in patients with gastric cancer resembled that in patients with esophageal cancer. Making an analysis and contrasting the digestive tract microbiota in patients with little intestine and gastric cancers cells was difficult due to the reduced incidence of little digestive cancer.

Source link: https://pubag.nal.usda.gov/catalog/7413867


Inhibition of SOCS6 confers radioresistance in esophageal squamous cell carcinoma

Esophageal cancer is just one of the most typical cancer of the digestive system and radiotherapy is widely applied in innovative esophageal cancer treatment, nevertheless radioresistance is one of the major reasons for radiotherapy failure. There is limited understanding on the mechanisms that trigger RR, here we determine suppressors of cytokine signaling 6 is an unfavorable regulator of radioresistance in ESCC cells. Importantly we located that very associated SOCS6 and P53 reveal reduced in RR esophageal cancer cells compare to radiosensitive ones.

Source link: https://pubag.nal.usda.gov/catalog/7306281


Dysbiosis of gut microbiota in patients with esophageal cancer

A variety of studies have determined that gut microbiota affects the development of cancer. The purpose of this study was to check out the gut microbiota profile connected with EC. In this research, 23 patients with EC and 23 sex- and age-matched healthy controls were recruited in between July 2019 and August 2019 at Huai'an First People's Hospital and the intestine microbiota was examined by 16S rRNA genetics sequencing of fresh feces samples. We located that the microbial splendor of digestive plants in patients with EC were greater than NC, whereas consistency did not transform obviously. Principal coordinate evaluation and Unweighted Pair Group Method with Arithmetic Mean evaluation both revealed that an unique separation in bacterial community composition between the EC and NC. This study firstly characterized the intestine microbiota structure of EC patients and screened out the optimum prospective microbiota biomarkers for EC diagnosis.

Source link: https://pubag.nal.usda.gov/catalog/7221430


Is Preoperative G-Tube Use Safe for Esophageal Cancer Patients?

Purpose: Gastrostomy tubes have been used with caution prior to esophageal resection because of the dangers of shot metastasis and of injury to the gastric avenue used for repair. In this study, we aim to review the security of preoperative g-tube positioning by contrasting end results in patients undergoing esophageal resection with and without prior g-tube use. We consisted of only patients that obtained neoadjuvant therapy and recognized 65 patients that received preoperative dietary assistance through a g-tube and 657 who did not. Demographics, postoperative difficulties, survival, and cancer reappearance rates were compared in between GT + and GT-- utilizing Chi-squared and Kaplan-- Meier survival evaluations. GT + was linked with a dramatically reduced total survival contrasted to GT--, and tumor reoccurrence rates were comparable. Our data recommend that g-tube usage is risk-free for patients with esophageal cancer requiring preoperative nutrition.

Source link: https://pubag.nal.usda.gov/catalog/6950183


Near-infrared fluorescence-guided resection of micrometastases derived from esophageal squamous cell carcinoma using a c-Met-targeted probe in a preclinical xenograft model

The postoperative survival of esophageal squamous cell carcinoma is especially impeded by cancer recurrence as a result of trouble in determining occult metastases. In vivo buildup of SHRmAb-IR800 and the potential application of NIRF-guided surgical treatment were assessed in eSCC xenograft growth versions. c-Met expression in human eSCC samples and lymph node metastases was analyzed using immunohistochemistry. Cellular build-up of SHRmAb-IR800 was greater in c-Met-positive EC109 eSCC cells than in c-Met-negative A2780 cells. Mixture of SHRmAb-IR800 generated greater fluorescence intensity and a higher tumor-to-background ratio than the control probe in EC109 subcutaneous lumps. IHC results demonstrated favorable discoloration in 97. 64% of eSCC samples and 91. 67% of LNMs. Taken with each other, the outcomes of this research study suggested that SHRmAb-IR800 helped with the resection of micrometastases of eSCC in the xenograft growth model. This c-Met-targeted probe possesses translational possibility in NIRF-guided surgical procedure as a result of the high favorable rate of c-Met healthy protein in human eSCCs.

Source link: https://pubag.nal.usda.gov/catalog/7289860

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions