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Esophageal Cancer - Europe PMC

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Last Updated: 13 May 2022

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A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer.

Fv-LDP-D3-AE and its antibody-drug conjugate Fv-LDP-D3-AE against esophageal cancer are among the targeting fusion protein Fv-LDP-D3-E and its antibody-drug conjugate Fv-LDP-D3-AE's esophageal cancer's primary tumor thrombosis. The fragment variable of an anti-EGFR antibody, the apoprotein of lidamycin, and the third domain of human serum albumin containing an esophageal cancer cells, exhibited a high binding affinity for EGFR-overexpressing esophageal cancer cells, impeded EGFR phosphorylation, and downregulated inosine monophosphate dehydrogenase type II expression, according to Fv-LDP-D3. The Fv-LDP-D3 gene was secretly imported by cancer cells by intensive macropinocytosis; it stopped cell proliferation and triggered esophageal cancer cell apoptosis. Both of Fv-LDP-D3 and Fv-LDP-D3-AE, as well as other related products, markedly inhibited the growth of esophageal cancer xenografts in athymic mice at high tolerated doses. The present findings reveal that Fv-LDP-D3, as well as Fv-LDP-D3-AE have potent antitumor efficacy when targeting EGFR, which could make them promising candidates for targeted therapy against esophageal cancer.

Source link: https://europepmc.org/article/MED/35416106


Stem signatures associating SOX2 antibody helps to define diagnosis and prognosis prediction with esophageal cancer.

Background esophageal cancer is one of the world's deadliest illnesses. The specificity of P53, PGP9. 5, SOX2, and CAGE were positively linked to esophageal cancer, and were strongly associated with the test group, with the test group's sensitivity of P53, SOX2, PGP8. 5, 56. 7 percent, and 48. 6%, respectively, with the test group's specificity reaching 76. 6 percent, 78. 6%, 86. 6%, and 86. 6 percent. The stem signatures-associated with esophageal cancer diagnosis and diagnosis may be used to aid in early diagnosis and diagnosis of esophageal cancer diagnosis, as well as providing timely and accurate treatments.

Source link: https://europepmc.org/article/MED/35382656


The association between surgical patient selection and hospital variation in failure to cure in esophageal cancer surgery. A nation-wide cohort study.

This report seeks to determine whether hospitals providing surgery to a substantial number of patients have higher failure-to-cure rates than hospitals operating fewer patients. Methods; From the Netherlands Cancer Registry, all cT1-cT4a/cM0 esophageal cancer patients diagnosed in 2015-2018 were included. Hospitals were divided into three categories: 1. hospitals that serve a large number of patients, 2. average hospitals, and 3. hospitals that treat surprisingly few patients with surgery. Patients in hospitals with low surgical rates O/E ratio > 54% after categorizing, 1,003 patients underwent surgery in hospitals with low surgical error percentages O/E ratio 0. 94/corrected percentage 4. 8 percent after categorizing, 54%, 1,297 patients in average hospitals and 1,137 patients in hospitals treating many patients surgically O/E ratio > 54%. Conclusion/Conclusion: Failure-to-cure rates were similar in hospitals with a high surgical rate and hospitals with a low incidence, according to the author. Patients who are undergoing a resection may be a candidate for recovery. Increasing the number of patients undergoing a resection may provide more patients with the possibility of healing.

Source link: https://europepmc.org/article/MED/35545020


Mapping of Lymph Node Metastasis From Thoracic Esophageal Cancer: A Retrospective Study.

Objectives This retrospective review was intended to determine the right extent of dissection for thoracic esophageal cancer in relation to the prevalence of lymph node metastasis. Methods We retrospectively identified 1014 patients with thoracic esophageal carcinoma who underwent esophagectomy at our hospital between May 2018 and November 2020. Generally, the LNM in thoracic EC may be arranged in the declining order of station 7> station 106recR> station 2> station 106recL. Along the bilateral recurrent laryngeal nerve, Esophageal cancer in the middle and lower thoracic segment also had a high incidence of LNM in the middle and lower thoracic segment. Independent risk factors for LNM and neoadjuvant therapy did not influence the distribution of LNM in thoracic EC cases, including cT3-4, cN+, or G3 in the case. Conclusions This research provided the most complete overview of LNM in thoracic EC patients. In thoracic EC patients, Neoadjuvant therapy did not improve overall distribution of LNM.

Source link: https://europepmc.org/article/MED/35543907


Real-world treatment patterns and outcomes in Japanese patients with cervical esophageal cancer.

Cervical esophageal cancer has a poor prognosis, but optimal CEC therapy remains to be developed due to its low incidence. The aim of this research was to clarify the current status of CEC treatment in Japan and find evidence for establishing the correct treatment technique. We asked specialty training centers accredited by the Japanese Broncho-Esophageal Society to register CEC cases that received curative care from January 2009 to December 2014, as well as a retrospective analysis of 302 cases reported from 27 facilities. The functional laryngeal preservation rate at the end of the study period was 38. 8% among the patients who underwent IC or CRT as laryngeal-preserving surgery at the time of the initial diagnosis.

Source link: https://europepmc.org/article/MED/35525856


The spatiotemporal correlation of PM2.5 concentration on esophageal cancer hospitalization rate in Fujian province of China.

This paper sought to investigate the link between PM2. 5 chemistry and hospitalization rate of esophageal cancer in Fujian province, as well as the effective lag effect on both PM2. 5 and hospitalization rates in 70 counties from both linear and nonlinear variables. The geographical distribution of esophageal cancer in 2016 was not consistent with that of the PM2. 5 average in the same year, according to the report. Our findings revealed that there was a 13-year lag period of air pollutant PM2. 5 on the esophageal cancer hospitalization rate, which could provide useful insight in the early screening process of esophageal cancer in Fujian.

Source link: https://europepmc.org/article/MED/35524092


Low mitochondrial DNA copy number induces chemotherapy resistance via epithelial-mesenchymal transition by DNA methylation in esophageal squamous cancer cells

Methods: Low mtDNA copy number was found in connection with chemotherapy resistance in 88 patients who underwent surgery after neoadjuvant chemotherapy. Since the mechanisms by which mtDNA copy number influences EMT, the present study concentrated on modulation of mitochondrial membrane potential and DNA methylation. ESCC patients with reduced mtDNA copy number who underwent R0 resection after neoadjuvant chemotherapy had markedly reduced pathological response and recurrence-free survival. Assays in vitro and in vivo assays show that depletion of mtDNA and low MMP caused DNA methylation by a DNA methylation transcription factor and a DNMT inhibitor suppressed EMT and enhanced chemotherapy sensitivity in mtDNA-depleted ESCC cells. Conclusion: In ESCC, decreased mtDNA copy number caused EMT via modulation of MMP and DNA methylation. Increased mtDNA copy number and DNMT inhibitors may be helpful in preventing EMT and chemosensitivity resistance.

Source link: https://europepmc.org/article/PPR/PPR489661


Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway.

CirRNA expression profiling results from the Gene Expression Omnibus database were used to determine circRNAs that were differentially expressed between ESCC tissues and paracancerous tissues, allowing for the analysis of circRNAs that were differentially expressed between ESCC tissues and paracancerous tissues. In ESCC tissues and cells, quantitative real-time polymerase chain reaction was carried out to determine circ_0023984 expression and miR-1294 expression. The use of a Western blot assay was used to determine phosphorylated-Akt expression and c-Myc expression in a forensic fashion. Circulation 0023984 overexpression was correlated with advanced clinical stage and lymph node metastasis of ESCC patients. Overexpression by Cir_0023984 enhanced ESCC cell proliferation, migration, invasion, and cell cycle progression, while cell cycle progression was reversed, while circ_0023984 showed the opposite effect. At G0/G1 phase, miR-1294 may significantly reduce ESCC cell proliferation, migration, invasion, and cell cycle arrest. miR-1294's target genes were identified with cell cycle arrest and the PI3K-Akt signaling pathway, according to the target genes. Cir_0023984 supports ESCC cells' malignant biological functions by blocking miR-1294 and opening the PI3K/Akt/c-myc pathway.

Source link: https://europepmc.org/article/MED/35522362


Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis.

Esophageal cancer is often thought of as a lethal tumor and is often detected at a later stage. Growing evidence points to the role of the esophageal microbiome, inflammation, and cellular components in tumorigenesis. The current analysis summarizes new research that delineates the key biologic mechanisms by which the microbiota and inflammation promote esophageal cancer's pathophysiology, allowing for future therapeutic intervention.

Source link: https://europepmc.org/article/MED/35511379


Thoracolaparoscopic esophagectomy for esophageal cancer with a cervical incision to extract specimen.

Surgical intervention is the most common and cost-effective therapy for resectable esophageal cancer. This research was conducted to determine the safety and reliability of neck incision to retrieve surgical tissue in thoracolaparoscopic esophageal cancer surgery. Materials and methods Thirty-four patients who underwent thoracolergic cancer, as well as a neck incision for extraction of surgical specimens were enrolled. The median surgical time was 309 minutes, with the median blood loss of 186 ml, with the average length of hospital stay of 11. 5 days. In five patients, anastomotic leakage was noted, with one patient being treated conservatively to recover, and four others undergoing interventional drainage. In five patients, ileus in three patients and anastomotic stenosis in two patients were present, including ileus in three patients and anastomotic stenosis in two patients. Conclusions The cervical incision to extract surgical specimen is safe and effective, as well as enhanced cosmetic appearance in thoracoleparoscopic esophageal cancer esophageal cancer surgery.

Source link: https://europepmc.org/article/MED/35525693

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions