Esophageal Cancer - DOAJ

Survival Risk Prediction of Esophageal Cancer Based on the Kohonen Network Clustering Algorithm and Kernel Extreme Learning Machine

The accuracy of determination of appropriate treatment strategies is crucial for accurate diagnosis. However, considering that the characteristics of blood index vary with individuals based on their age, personal preferences, and living environment, etc. , a unified artificial intelligence prediction system is not particularly effective. This report recommends a new model based on the Kohonen network clustering algorithm and the kernel extreme learning machine in order to increase the model's accuracy in the detection of esophageal cancer survival risks, aiming to divide the test population into five catergories and increase machine learning's effectiveness. The results revealed that the prediction model developed in this research had certain advantages in terms of prediction accuracy and running time, as well as assisting medical staff in choosing the treatment method for esophageal cancer patients.

Source link: https://doi.org/10.3390/math10091367

Association of Esophageal Cancer Mortality with Municipal Socioeconomic Deprivation Level in Japan, 2013–2017: An Ecological Study Using Nationwide Data

This study sought to establish geographic variation in esophageal cancer mortality in Japan and reveal an association of esophageal cancer mortality with municipal socioeconomic deprivation level. The relative risk of esophageal cancer mortality in men and women increased as a result of regression analysis, and the relative risk of esophageal cancer mortality was significantly higher in quintile 5 than quintile 1 in men and women. According to these studies, deprivation level elevates the risk of esophageal cancer mortality in Japan.

Source link: https://doi.org/10.3390/ijerph19095483

Difference between “Lung Age” and Real Age as a Novel Predictor of Postoperative Complications, Long-Term Survival for Patients with Esophageal Cancer after Minimally Invasive Esophagectomy

paraphrasedoutput:MethodsThis retrospective cohort study included 625 consecutive patients with MIE as well as real age and actual age in patients with esophageal cancer and long-term survival in patients with esophageal cancer, as well as minimally invasive esophagectomy. Patients were divided into three groups by L–R: L–R 0; group A: L—R 0; group B: 15 0; group B: L–R> 0; group A: L–R 15, group B: L–R> 0; group C: L–R> 15, group A: According to L–R, patients were divided into three groups: group A: L–R 0 ; group B: CCI values, postoperative hospital stays, and hospital prices were substantially different between groups. ConclusionsEsophageal cancer patients with impaired respiratory health and worse prognosis were at a higher risk of severe postoperative complications and poorer prognosis than those with normal pulmonary function.

Source link: https://doi.org/10.3389/fsurg.2022.794553

Artesunate Inhibits the Development of Esophageal Cancer by Targeting HK1 to Reduce Glycolysis Levels in Areas With Zinc Deficiency

Zindeficiency promotes the cell cycle, therefore increasing the propagation of EC in areas with a high prevalence of EC. Our previous research revealed that zinc deficiency promotes the cell cycle, thereby encouraging the propagation of EC. In this research, we first established the mechanism by which artesunate blocks EC in vitro and then demonstrated that artesunate can reverse ZD-promoted decline in ZD-promoted EC in vivo before EC occurs in vivo. Artesunate has an anti-EC role by inhibiting aerobic glycolysis, and it has the potential to be a drug that reduces EC in areas of high risk of EC.

Source link: https://doi.org/10.3389/fonc.2022.871483

P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

Using Western blotting, overexpressing and knocking down PCAF expression in esophageal squamous cell carcinoma cells was identified by creating a specific antibody against acetylated Fascin acetylation in esophageal squamous cell carcinoma cells using Western blotting. Using immunohistochemistry, the clinical significance of acetylated Fascin and PCAF in ESCC was determined. Results by the PCAF Fascin directly collaborated and colocalized with PCAF in the cytoplasm, and was acetylated at lysine 471 by PCAF. Fascin was found to be acetylated in ESCC cells, and the acetylation level was then increased after PCAF overexpression and reduction after PCAF's knockdown. FascinK471 acetylation dramatically reduced in vitro ESCC cell migration and in vivo tumor metastasis in vitro, and in vivo tumor metastasis, while FascinK471 deacetylation demonstrated a potent oncogenic role. ESCC patients with elevated serum AcK471Fascin levels were strongly associated with prolonged overall survival and disease-free survival.

Source link: https://doi.org/10.1002/cac2.12221

Risk stratification of cirrhotic patients undergoing esophagectomy for esophageal cancer: A single-centre experience.

However, only few studies are available on cirrhotic patients requiring esophagectomy for malignant disease. Patients with concomitant liver cirrhosis were compared to non-liver-cirrhotic patients, according to a prospectively maintained database of esophageal cancer patients who underwent curative esophagectomy between 01/2012 and 01/2016. Conclusions of 170 patients and 14 cirrhotic patients with predominately low MELD scores were found. Conclusion Curative esophagectomy for cirrhotic patients is often associated with a poor prognosis and should be scrutinized more closely. While MELD and Child score were unable to forecast perioperative death, Bilirubin and INR demonstrated solid prognostic capacity in this cohort.

Source link: https://doi.org/10.1371/journal.pone.0265093

Better Prognosis and Survival in Esophageal Cancer Survivors After Comorbid Second Primary Malignancies: A SEER Database-Based Study

Multiple Cox regression equation estimations were performed under various covariate adjustment schemes, as well as a stratified review of multiple Cox regression equation equations based on various covariate adjustment models. Results We found the EC-SPM group's median survival time was 47. 99 months, with a second primary malignant tumor. Conclusion The EC-SPM group had a reduced risk of death in comparison to the one primary malignancy only group whose second primary malignant cancer had a higher prognosis, but needed more aggressive therapy.

Source link: https://doi.org/10.3389/fsurg.2022.893429

Comparison of Long-Term Survival Between cT1N0 Stage Esophageal Cancer Patients Receiving Endoscopic Dissection and Esophagectomy: A Meta-Analysis

ConclusionOverall, the latest results showed that the long-term survival of cT1N0 esophageal cancer patients receiving ED was not worse than that of patients undergoing esophagectomy.

Source link: https://doi.org/10.3389/fsurg.2022.917689

Efficacy of Bevacizumab and Gemcitabine in Combination with Cisplatin in the Treatment of Esophageal Cancer and the Effect on the Incidence of Adverse Reactions

To determine the safety of bevacizumab and gemcitabine in combination with cisplatin in the treatment of esophageal cancer, and the consequences on adverse reactions, see the table below. Patients admitted to our hospital from March 2019 to March 2021 were identified as research subjects and then randomized into the control group and the study group, with 50 patients in each group. Both groups were reduced after chemotherapy, with significantly lower figures in the experimental group than in the control group. Patients in the study group's survival rates were 88% and 54% at 1 and 2 years after treatment, much higher than those in the control group's 68% and 32%.

Source link: https://doi.org/10.1155/2022/2317181

Sequential treatment of severe airway stenosis caused by esophageal cancer by using airway stent implantation and arterial infusion chemotherapy

Abstract The aim of this scientific research was to investigate the efficacy and safety of airway stent placement and transarterial infusion chemotherapy in the sequential treatment of severe airway stenosis caused by esophageal cancer. Patients with advanced esophageal cancer complicated by severe airway stenosis treated with airway stent implantation and transarterial infusion chemotherapy were retrospectively reviewed. After airway stent implantation, there were 28 patients with grade III dyspnea and 43 patients with grade IV dyspnea, 43 patients with grade IV dyspnea, and 34 patients with grade III dyspnea, 35 patients with grade II dyspnea, and two patients with grade III dyspnea and 42 patients with grade IV dyspnea before airway stent implantation, as well as 31 patients with grade III dyspnea 11, 41 and 19 patients had complete response, partial response, and stable response respectively after airway stent implantation and 1–3 courses of transarterial infusion chemotherapy, with partial response and steady response. Airway stent implantation in conjunction with arterial infusion chemotherapy is safe and effective for repeat treatment of esophageal cancer with severe airway stenosis.

Source link: https://doi.org/10.1038/s41598-022-10888-4

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