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Esophageal Cancer - Astrophysics Data System

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Last Updated: 13 May 2022

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Risk stratification of cirrhotic patients undergoing esophagectomy for esophageal cancer: A single-centre experience

Concomitant liver cirrhosis is a significant risk factor for major surgical procedures. However, only few studies are available on cirrhotic patients who need esophagectomy for malignant disease. Patients with concomitant liver cirrhosis were compared to non-liver cirrhotic patients, according to a prospectively maintained database of esophageal cancer patients who underwent curative esophagectomy between 01/2012 and 01/2016. Perceptions of 170 patients and 14 cirrhotic patients with predominately low MELD scores were identified. Conclusions Citrhotic patients' cirrhotic prognosis is often associated with a dismal prognosis, and it should be monitored closely.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765093G/abstract


Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells

Although several cell-cycle regulators are involved in this process, it is unclear to what extent cell senescence, first described as irreversible growth arrest in vitro, contributes to the aging process. We found esophageal cancer-related gene 4 as a senescence inducer in the aged brain, using a serum-induced mouse oligodendrocyte precursor cell senescence model. Although mOPCs could proliferate indefinitely when cultured in the correct medium, they became senescent in serum presence and maintained their senescent phenotype even when the serum was later replaced by OPC medium, although the serum was later replaced by OPC medium. We also showed that senescent OPCs undercoverd Ecrg4 and that recombinant Ecrg4 stimulated OPC senescence in culture. Moreover, increased Ecrg4 expression was found in the OPCs and neural precursor cells of the aged mouse brain, as well as the expression of senescence-associated -galactosidase activity, indicating the cells' emergence into senescence.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107.8259K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions