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Here, we synthesized a nano-material in which Ag nano-particles were assembled with a ZnO nano-structure to create an Ag-ZnO nano-composite at low temperature. In antibacterial and morphological tests, the antibacterial activity of AZE samples against both Escherichia coli and S. aureus strains, as well as MRSA was determined. The AZE3 sample had greater antibacterial activity than the other samples and was comparable to erythromycin. Following multiple exposures to bacteria compared to erythromycin alone, AZE3 was 20-fold less likely to develop bacterial resistance following multiple exposures to bacteria. With 293 human embryonic kidney cells, the AZE3 nanocomposite showed good biocompatibility.
Source link: https://doi.org/10.3390/pharmaceutics12090841
Due to the effects of manure application in the ecosystem, ery is often present in agricultural fields. Based on our finding of a decrease in chlorophyll levels using Brassica campestris, we carried out this research to determine the molecular causes of Ery toxicity during seedling expansion. According to a cell process and a metabolic process, many of these DAPs responding to Ery therapy resulted in a physiological process and a metabolic process, according to gene ontology classification. According to the molecular function investigation, DAPs classified within catalytic activity were mostly changed by Ery, including metabolite interconversion enzyme and protein modifying enzyme. As determined by qPCR results, a good relationship was found between protein and transcript abundance in a photosynthetic pathway. These combined findings show that Ery may influence plant physiological function by downregulating protein levels in the photosynthetic pathway.
Source link: https://doi.org/10.3390/life10120311
One of many problems that arise with the topical administration of conventional dosage forms is the rapid removal of drugs from the cornea. The present paper attempted to produce erythromycin-infused erythromycin inserts to improve drug delivery and address the aforementioned drawback. The film-casting technique was used to produce the mucoadhesive films using sodium alginate, gelatin, cyclodextrin-u03b1, and u03b2 as polymeric film matrices. With more than 20 mm diameter of inhibited growth zones, both formulations demonstrated antibacterial activity against E. coli and S. aureus. During the first 120 hours of study, the inserts showed promising pharmacokinetics with AUC 0u201336,000 b7g/mL, a C max of more than 1800 g/mL at 4 h, and maintained drug concentration above the threshold of 5 g/mL. As ocular inserts, nanoparticle-containing, mucoadhesive films could be produced as ocular inserts that can extend the topical ocular delivery of ERY.
Source link: https://doi.org/10.3390/biomedicines10081917
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